{"id":10456,"date":"2011-04-01T20:35:46","date_gmt":"2011-04-01T17:35:46","guid":{"rendered":"http:\/\/109.232.216.219\/~bilimvegelecek\/?p=10456"},"modified":"2017-05-26T20:38:13","modified_gmt":"2017-05-26T17:38:13","slug":"depresyon-ilaclari-beyin-fizyolojisini-degistirebilir-mi","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2011\/04\/01\/depresyon-ilaclari-beyin-fizyolojisini-degistirebilir-mi","title":{"rendered":"Depresyon ila\u00e7lar\u0131 beyin fizyolojisini de\u011fi\u015ftirebilir mi?"},"content":{"rendered":"<p><em><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-10457 alignleft\" src=\"https:\/\/bilimvegelecek.com.tr\/wp-content\/uploads\/2017\/05\/13-2-175x300.jpg\" alt=\"\" width=\"175\" height=\"300\" srcset=\"https:\/\/bilimvegelecek.com.tr\/wp-content\/uploads\/2017\/05\/13-2-175x300.jpg 175w, https:\/\/bilimvegelecek.com.tr\/wp-content\/uploads\/2017\/05\/13-2-246x420.jpg 246w, https:\/\/bilimvegelecek.com.tr\/wp-content\/uploads\/2017\/05\/13-2.jpg 259w\" sizes=\"auto, (max-width: 175px) 100vw, 175px\" \/>Molecular Brain <\/em><em>dergisinde yay\u0131nlanan yeni bir ara\u015ft\u0131rma, <\/em>serotonin geri al\u0131m inhibit\u00f6rleriyle yap\u0131lan (<em>SSRI) tedavinin neden oldu\u011fu beyin i\u00e7indeki fizyolojik de\u011fi\u015fiklikleri g\u00fcn \u0131\u015f\u0131\u011f\u0131na \u00e7\u0131kar\u0131yor. <\/em><\/p>\n<p>Prozac gibi \u201cse\u00e7ici serotonin geri al\u0131m inhibit\u00f6rleri\u201d (SSRI) a\u011f\u0131r depresyon ve bunal\u0131m tedavisinde kullan\u0131lmaktad\u0131r. Beyindeki serotonin miktar\u0131nda ani art\u0131\u015fa sebep olarak ve beyin fonksiyonlar\u0131nda uzun s\u00fcreli de\u011fi\u015fiklikler yaparak \u00e7al\u0131\u015f\u0131rlar. Bununla birlikte, hastan\u0131n herhangi bir etkiyi hissetmesi i\u00e7in tedavinin haftalarca s\u00fcrmesi gerekebilir. Bu t\u00fcr ila\u00e7lar\u0131n hem yararl\u0131 etkileri hem de yan etkileri tedavi sonland\u0131r\u0131ld\u0131ktan sonra bile devam edebilir.<\/p>\n<p>Hipokampus, uzun s\u00fcreli belle\u011fin ve mek\u00e2nsal bilincin olu\u015fmas\u0131nda g\u00f6revli beynin bir b\u00f6l\u00fcm\u00fcd\u00fcr. Alzheimer hastal\u0131\u011f\u0131 olan ki\u015filerde, hipokampus i\u00e7inde ger\u00e7ekle\u015fen d\u00fczensizliklerin uyum bozuklu\u011fu ve bellek kayb\u0131 gibi semptomlar\u0131n olu\u015fmas\u0131na neden oldu\u011fu bilinmektedir. Hipokampusu olu\u015fturan sinir h\u00fccreleri, h\u00fccresel aktivitelerinde ve birbirleriyle olan ba\u011flant\u0131lar\u0131nda de\u011fi\u015fiklikler yaparak yeni hat\u0131ralar\u0131n olu\u015fmas\u0131n\u0131 sa\u011flarlar. Hayat boyunca devam eden bu s\u00fcrece plastisite (esneklik) ad\u0131 verilir ve de\u011fi\u015fmi\u015f plastisitenin depresyon ve stresle ba\u011flant\u0131l\u0131 oldu\u011fu \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0bilinmektedir.<\/p>\n<p>Nippon T\u0131p Fak\u00fcltesi Farmakoloji B\u00f6l\u00fcm\u00fcnde (Japonya) yap\u0131lan ara\u015ft\u0131rmada, yeti\u015fkin farelerin fluoxetine (Prozac) ile tedavisinde, hipokampusu olu\u015fturan temel sinir h\u00fccrelerinden biri olan gran\u00fcl h\u00fccrelerinde ve di\u011fer sinir h\u00fccreleriyle olan ba\u011flant\u0131lar\u0131nda de\u011fi\u015fimler oldu\u011fu g\u00f6sterilmi\u015f. Gran\u00fcl h\u00fccrelerinde, serotonindeki art\u0131\u015f nedeniyle h\u00fccresel olgunla\u015fman\u0131n durdu\u011fu, buna ba\u011fl\u0131 olarak da h\u00fccresel aktivitede art\u0131\u015f oldu\u011fu ve yeti\u015fkin tipi plastisitenin olgunla\u015fmam\u0131\u015f duruma ge\u00e7ti\u011fi g\u00f6zlemlenmi\u015f. \u00a0H\u00fccrelerin plastisitesinde ger\u00e7ekle\u015fen bu de\u011fi\u015fimler nedeniyle, farelerin bunal\u0131m ve depresyon belirtileri g\u00f6sterdikleri g\u00f6zlemlenmi\u015f.<\/p>\n<p>Ara\u015ft\u0131rmay\u0131 yapan ekip, Prozac ile tedavi olan insanlarda g\u00f6r\u00fclen bunal\u0131m ve davran\u0131\u015f de\u011fi\u015fikli\u011fi gibi yan etkilerin hipokampus i\u00e7indeki gran\u00fcl h\u00fccrelerinde meydana gelen h\u00fccresel olgunla\u015fman\u0131n durmas\u0131ndan kaynaklanabilece\u011fini \u00f6ne s\u00fcr\u00fcyor.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Kaynak:<\/strong>\u00a0 BioMed Central. \u201cDepression drugs &#8212; SSRIs &#8212; may reorganize brain plasticity, new research suggests.\u201d <u>ScienceDaily<\/u>, (20 Mart 2011) &lt;http:\/\/www.sciencedaily.com\u00ad\/releases\/2011\/03\/ 11031608 4425.htm&gt;.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Molecular Brain dergisinde yay\u0131nlanan yeni bir ara\u015ft\u0131rma, serotonin geri al\u0131m inhibit\u00f6rleriyle yap\u0131lan (SSRI) tedavinin neden oldu\u011fu beyin i\u00e7indeki fizyolojik de\u011fi\u015fiklikleri g\u00fcn \u0131\u015f\u0131\u011f\u0131na \u00e7\u0131kar\u0131yor. Prozac gibi \u201cse\u00e7ici serotonin geri al\u0131m inhibit\u00f6rleri\u201d (SSRI) a\u011f\u0131r depresyon ve bunal\u0131m tedavisinde kullan\u0131lmaktad\u0131r. Beyindeki serotonin miktar\u0131nda ani art\u0131\u015fa sebep olarak ve beyin fonksiyonlar\u0131nda uzun s\u00fcreli de\u011fi\u015fiklikler yaparak \u00e7al\u0131\u015f\u0131rlar. Bununla birlikte, hastan\u0131n [&hellip;]<\/p>\n","protected":false},"author":348,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[123,19],"tags":[686,287,289],"class_list":["post-10456","post","type-post","status-publish","format-standard","hentry","category-86-sayi","category-bilim-gundemi","tag-depresyon","tag-farmakoloji","tag-fizyoloji"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/10456","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/348"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=10456"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/10456\/revisions"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=10456"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=10456"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=10456"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}