{"id":10459,"date":"2011-04-01T20:38:39","date_gmt":"2011-04-01T17:38:39","guid":{"rendered":"http:\/\/109.232.216.219\/~bilimvegelecek\/?p=10459"},"modified":"2017-05-26T20:40:09","modified_gmt":"2017-05-26T17:40:09","slug":"david-ve-goliath-virusleri-sicrama-genlerinin-kokenini-aciga-kavusturdu","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2011\/04\/01\/david-ve-goliath-virusleri-sicrama-genlerinin-kokenini-aciga-kavusturdu","title":{"rendered":"\u2018David ve Goliath\u2019 vir\u00fcsleri s\u0131\u00e7rama genlerinin k\u00f6kenini a\u00e7\u0131\u011fa kavu\u015fturdu"},"content":{"rendered":"

British\u00a0Columbia\u00a0\u00dcniversitesi\u2019nden ara\u015ft\u0131rmac\u0131lar, kendinden 100 kat daha b\u00fcy\u00fck vir\u00fcslere sald\u0131ran ve infekte olmu\u015f zooplanktonlar\u0131 \u00f6l\u00fcmden kurtaran k\u00fc\u00e7\u00fck bir vir\u00fcs belirlediler. Bu ke\u015fif di\u011fer organizmalarda bulunan baz\u0131 s\u0131\u00e7rama genlerinin evrimsel k\u00f6keni hakk\u0131nda ipu\u00e7lar\u0131 veriyor.<\/p>\n

UBC deniz mikrobiyolo\u011fu Curtis Suttle ve doktora \u00f6\u011frencisi Matthias Fischer taraf\u0131ndan y\u00fcr\u00fct\u00fclen \u00e7al\u0131\u015fma, Science Express<\/em>\u2019in 3 Mart\u2019taki say\u0131s\u0131nda online olarak yay\u0131nland\u0131. \u00c7al\u0131\u015fma, bir deniz vir\u00fcs\u00fc olan Mavir\u00fcs\u2019\u00fc ve onun d\u00fcnyan\u0131n en b\u00fcy\u00fck deniz vir\u00fcsleri olan Cafeteria roenbergenesis<\/em> ve CroV<\/em> ile olan etkile\u015fimini a\u00e7\u0131kl\u0131yor.<\/p>\n

Suttle; \u201cMavir\u00fcs\u2019\u00fcn, Cafeteria roenbergeneis<\/em> vir\u00fcs\u00fcn\u00fc \u00f6nce infekte etmesi ve devam\u0131nda da onu\u00a0 CroV taraf\u0131ndan enfekte edilmekten korumas\u0131, David ve Goliath hik\u00e2yesinin mikrobiyal bir versiyonudur\u201d dedi.<\/p>\n

Vir\u00fcsler\u00a0\u00e7o\u011falmak\u00a0i\u00e7in\u00a0konak\u00a0h\u00fccrelere\u00a0ba\u011f\u0131ml\u0131d\u0131r. Mavir\u00fcs durumunda ise; konak h\u00fccre yine ba\u015fka bir vir\u00fcst\u00fcr. Bu da Mavir\u00fcs\u2019\u00fc bilinen ikinci virofaj yap\u0131yor. O, \u00e7o\u011falmak i\u00e7in CroV\u2019a ihtiya\u00e7 duyuyor ve \u00e7o\u011falma s\u00fcrecinde CroV\u2019un \u00fcremesini engelliyor.<\/p>\n

Suttle, \u201cBu etkile\u015fimin evrimsel biyoloji i\u00e7in \u00f6nemli olmas\u0131n\u0131n nedeni Mavir\u00fcs\u2019\u00fcn yak\u0131n genetik akrabalar\u0131n\u0131n, tek h\u00fccreli ve y\u00fcksek yap\u0131l\u0131 organizmalarda bulunan mobil genetik elementler olmas\u0131d\u0131r. Bu durum, evrimsel s\u00fcre\u00e7te organizmalar\u0131n kendi genomlar\u0131 i\u00e7inde Mavir\u00fcs\u2019\u00fcn antik akrabalar\u0131ndan se\u00e7ilip elenmi\u015f DNA\u2019lara sahip olduklar\u0131 ve muhtemelen bu y\u00fczden CroV gibi dev vir\u00fcslere kar\u015f\u0131 ba\u011f\u0131\u015f\u0131kl\u0131k kazanm\u0131\u015f olabilecekleri anlam\u0131na gelir.\u201d dedi.<\/p>\n

Transpozonlar ya da s\u0131\u00e7rama genleri, kendilerini organizman\u0131n genomu i\u00e7inde yeni bir pozisyona ta\u015f\u0131yabilen ya da \u201ctranspoz\u201d edebilen DNA par\u00e7alar\u0131d\u0131r. Ara\u015ft\u0131rmac\u0131lar, \u201cMaverick transpozonu<\/em>\u201d denilen transpozonlar\u0131n, kendi DNA dizilimlerinin do\u011fas\u0131 nedeniyle viral k\u00f6kenli olduklar\u0131ndan \u015f\u00fcpheleniyorlar.<\/p>\n

Suttle ve Fischer\u2019\u0131n Mavir\u00fcs \u00fczerindeki son \u00e7al\u0131\u015fmalar\u0131 bu ba\u011flant\u0131n\u0131n ilk somut kan\u0131t\u0131n\u0131 olu\u015fturuyor.<\/p>\n

Suttle, \u201cMuhtemelen organizmalar, genomlar\u0131 i\u00e7inde virofaj DNA\u2019lar\u0131na sahip olduklar\u0131ndan dolay\u0131, kendilerini korumak i\u00e7in ikinci bir vir\u00fcs taraf\u0131ndan enfekte olmak zorunda de\u011filler.\u201d diyor.<\/p>\n

Suttle ve Fischer daha \u00f6nceki \u00e7al\u0131\u015fmalar\u0131nda CroV vir\u00fcs\u00fcn\u00fc, karma\u015f\u0131k genom yap\u0131s\u0131yla birlikte konak h\u00fccresinden ba\u011f\u0131ms\u0131zla\u015fan d\u00fcnyan\u0131n en b\u00fcy\u00fck deniz vir\u00fcs\u00fc olarak tespit etmi\u015flerdi.<\/p>\n

 <\/p>\n

Kaynak<\/strong>: \u2018David and Goliath\u2019 Viruses Shed Light on the Orijin of Jumping Genes,<\/p>\n

http:\/\/www.sciencedaily.com\/releases\/2011\/03\/110303163322.htm adresinden 03.03.2011 tarihinde al\u0131nm\u0131\u015ft\u0131r.<\/p>\n","protected":false},"excerpt":{"rendered":"

British\u00a0Columbia\u00a0\u00dcniversitesi\u2019nden ara\u015ft\u0131rmac\u0131lar, kendinden 100 kat daha b\u00fcy\u00fck vir\u00fcslere sald\u0131ran ve infekte olmu\u015f zooplanktonlar\u0131 \u00f6l\u00fcmden kurtaran k\u00fc\u00e7\u00fck bir vir\u00fcs belirlediler. Bu ke\u015fif di\u011fer organizmalarda bulunan baz\u0131 s\u0131\u00e7rama genlerinin evrimsel k\u00f6keni hakk\u0131nda ipu\u00e7lar\u0131 veriyor. UBC deniz mikrobiyolo\u011fu Curtis Suttle ve doktora \u00f6\u011frencisi Matthias Fischer taraf\u0131ndan y\u00fcr\u00fct\u00fclen \u00e7al\u0131\u015fma, Science Express\u2019in 3 Mart\u2019taki say\u0131s\u0131nda online olarak yay\u0131nland\u0131. \u00c7al\u0131\u015fma, bir […]<\/p>\n","protected":false},"author":799,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[123,19],"tags":[205,492],"class_list":["post-10459","post","type-post","status-publish","format-standard","hentry","category-86-sayi","category-bilim-gundemi","tag-mikrobiyoloji","tag-virus"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t