{"id":11286,"date":"2011-06-01T20:08:53","date_gmt":"2011-06-01T17:08:53","guid":{"rendered":"http:\/\/109.232.216.219\/~bilimvegelecek\/?p=11286"},"modified":"2017-06-06T20:11:39","modified_gmt":"2017-06-06T17:11:39","slug":"yeni-bir-genetik-teknikle-deri-hucreleri-beyin-hucrelerine-donusturuldu","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2011\/06\/01\/yeni-bir-genetik-teknikle-deri-hucreleri-beyin-hucrelerine-donusturuldu","title":{"rendered":"Yeni bir genetik teknikle deri h\u00fccreleri beyin h\u00fccrelerine d\u00f6n\u00fc\u015ft\u00fcr\u00fcld\u00fc"},"content":{"rendered":"

\"\"Bilimde \u00e7\u0131\u011f\u0131r a\u00e7an yeni bir ara\u015ft\u0131rma, ergin deri h\u00fccrelerinin, k\u00f6k h\u00fccre a\u015famas\u0131ndan ge\u00e7meden, direkt olarak beyin h\u00fccresi olu\u015fturmak \u00fczere yeniden programlanabilece\u011fini kan\u0131tlad\u0131. Tahmin edilemeyecek kadar basit olan teknik, fetal s\u00fcre\u00e7te beyin h\u00fccresi olu\u015fumunda aktif oldu\u011fu bilinen \u00fc\u00e7 genin, deri h\u00fccrelerinde aktive edilmesinden olu\u015fmaktad\u0131r. Bu yeni teknik k\u00f6k h\u00fccre ara\u015ft\u0131rmalar\u0131 s\u0131ras\u0131nda kar\u015f\u0131la\u015f\u0131lan bir\u00e7ok etik ikilemi ortadan kald\u0131racakt\u0131r.<\/p>\n

\u0130sve\u00e7\u2019in Lund \u00dcniversitesi\u2019nden bir grup bilim insan\u0131, tarihte ilk kez insan derisinden al\u0131nan h\u00fccrelerden belirli tipteki sinir h\u00fccrelerini \u00fcretmeyi ba\u015fard\u0131. Fibroblast olarak adland\u0131r\u0131lan ba\u011f doku h\u00fccrelerinin, sinir h\u00fccresi olu\u015fturmak \u00fczere tekrar programlanmas\u0131, h\u00fccre transplantasyonunda potansiyel yeni alanlar yaratacak. Bu ke\u015fif g\u00f6steriyor ki ergin h\u00fccrelerin de\u011fi\u015fim kapasitesi ve fonksiyonel \u00f6zellikleri hakk\u0131ndaki g\u00f6r\u00fc\u015fler tam temelinden de\u011fi\u015fime u\u011fruyor. Lund \u00dcniversitesi ara\u015ft\u0131rmac\u0131lar\u0131, ba\u015flang\u0131\u00e7 noktas\u0131 olarak k\u00f6k h\u00fccreler yerine ergin h\u00fccreleri alarak embriyonik k\u00f6k h\u00fccre \u00e7al\u0131\u015fmalar\u0131 \u00fczerindeki etik problemleri de ba\u015flar\u0131ndan savm\u0131\u015f oluyorlar.<\/p>\n

Ara\u015ft\u0131rma grubunun lideri Malin Parmar, fibroblastlar\u0131n yeni talimatlar\u0131 ne kadar iyi alg\u0131lad\u0131\u011f\u0131n\u0131 g\u00f6rd\u00fcklerinde \u00e7ok \u015fa\u015f\u0131rd\u0131: \u201cBiz ger\u00e7ekten bu tekni\u011fin i\u015fe yarayaca\u011f\u0131n\u0131 d\u00fc\u015f\u00fcnmedik, ba\u015flang\u0131\u00e7ta bu sadece ilgin\u00e7 bir deneydi. Sonras\u0131nda ise h\u00fccrelerin s\u00fcrpriz bir bi\u00e7imde talimatlara uydu\u011funu g\u00f6zlemledik.\u201d Proceedings of the National Academy of Sciences<\/em>\u2019\u0131n son say\u0131s\u0131nda yay\u0131mlanan bu ara\u015ft\u0131rma g\u00f6steriyor ki deri h\u00fccreleri spesifik sinir h\u00fccrelerine d\u00f6n\u00fc\u015ft\u00fcr\u00fclebilir.<\/p>\n

\u0130ki genin daha aktive edildi\u011fi ileri deneylerde, ara\u015ft\u0131rmac\u0131lar Parkinson hastal\u0131\u011f\u0131na yakalanan ki\u015filerde \u00f6l\u00fc durumda olan dopamin beyin h\u00fccrelerini \u00fcrettiler. Ara\u015ft\u0131rman\u0131n bulgular\u0131 sinir h\u00fccresi \u00fcretiminde, transplant olarak hastan\u0131n kendi h\u00fccrelerinin kullan\u0131m\u0131na olanak sa\u011fl\u0131yor. Bu h\u00fccreler pek \u00e7ok n\u00f6rodejeneratif hastal\u0131klar i\u00e7in de hastal\u0131k modelleri olarak kullan\u0131l\u0131yor.<\/p>\n

Eski yeniden programlama sistemlerinden farkl\u0131 olarak, bu sistemde h\u00fccreler IPS olarak bilinen pluripotent k\u00f6k h\u00fccrelerine d\u00f6n\u00fc\u015ft\u00fcr\u00fclm\u00fcyor; yani k\u00f6k h\u00fccre a\u015famas\u0131na gelmeden direkt olarak deri h\u00fccrelerinden sinir h\u00fccrelerine d\u00f6n\u00fc\u015ft\u00fcr\u00fcl\u00fcyor. K\u00f6k h\u00fccre a\u015famas\u0131n\u0131n bu \u015fekilde atlanmas\u0131 da, h\u00fccreler transplante edildi\u011finde olu\u015fabilecek olan t\u00fcm\u00f6r riskini b\u00fcy\u00fck olas\u0131l\u0131kla ortadan kald\u0131racak.<\/p>\n

Direkt d\u00f6n\u00fc\u015ft\u00fcrme tekni\u011finin klinik olarak uygulanabilmesinin \u00f6n\u00fcnde, bu yeni sinir h\u00fccrelerinin nas\u0131l hayatta kalacaklar\u0131na ve beyinde nas\u0131l i\u015flev g\u00f6stereceklerine dair yap\u0131lmas\u0131 gereken pek \u00e7ok deney var. Gelecek i\u00e7in bu ara\u015ft\u0131rman\u0131n sa\u011flad\u0131\u011f\u0131 ise, doktorlar\u0131n hastalar\u0131n ihtiyac\u0131 olan sinir h\u00fccrelerini basit birer deri veya sa\u00e7 h\u00fccresinden elde edebilecekleri ger\u00e7e\u011fidir. Buna ek olarak, hastan\u0131n kendi v\u00fccudundan al\u0131n\u0131p belirli bir \u015fekilde tasarlanan h\u00fccrelerin, hastan\u0131n ba\u011f\u0131\u015f\u0131kl\u0131k sistemi taraf\u0131ndan bir ba\u011f\u0131\u015f\u00e7\u0131dan al\u0131nan h\u00fccrelerden \u00e7ok daha iyi bir bi\u00e7imde kabul edilece\u011fi addediliyor.<\/p>\n

\u201cBu uzun bir ko\u015fudaki b\u00fcy\u00fck bir fikir. Umar\u0131z ki bir hastadan biyopsi yap\u0131larak dopamin h\u00fccreleri al\u0131ns\u0131n ve ard\u0131ndan Parkinson hastal\u0131\u011f\u0131n\u0131n tedavisi olarak transplant edilsin.\u201d diyor \u015fu an ba\u015fka t\u00fcr beyin h\u00fccrelerinin olu\u015fumu i\u00e7in yeni teknikler bulma konusunda \u00e7al\u0131\u015fan Malin Parmar.<\/p>\n

 <\/p>\n

Kaynak<\/strong>: ScienceDaily (June 13, 2011)<\/p>\n

http:\/\/www.sciencedaily.com\/releases\/2011\/06\/110609084815.htm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Bilimde \u00e7\u0131\u011f\u0131r a\u00e7an yeni bir ara\u015ft\u0131rma, ergin deri h\u00fccrelerinin, k\u00f6k h\u00fccre a\u015famas\u0131ndan ge\u00e7meden, direkt olarak beyin h\u00fccresi olu\u015fturmak \u00fczere yeniden programlanabilece\u011fini kan\u0131tlad\u0131. Tahmin edilemeyecek kadar basit olan teknik, fetal s\u00fcre\u00e7te beyin h\u00fccresi olu\u015fumunda aktif oldu\u011fu bilinen \u00fc\u00e7 genin, deri h\u00fccrelerinde aktive edilmesinden olu\u015fmaktad\u0131r. Bu yeni teknik k\u00f6k h\u00fccre ara\u015ft\u0131rmalar\u0131 s\u0131ras\u0131nda kar\u015f\u0131la\u015f\u0131lan bir\u00e7ok etik ikilemi ortadan […]<\/p>\n","protected":false},"author":806,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[126,19],"tags":[783,431,424],"class_list":["post-11286","post","type-post","status-publish","format-standard","hentry","category-89-sayi","category-bilim-gundemi","tag-dna-transplanti","tag-gen","tag-kok-hucre"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/11286","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/806"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=11286"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/11286\/revisions"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=11286"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=11286"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=11286"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}