{"id":12010,"date":"2014-08-01T22:13:09","date_gmt":"2014-08-01T19:13:09","guid":{"rendered":"http:\/\/109.232.216.219\/~bilimvegelecek\/?p=12010"},"modified":"2018-05-14T17:05:48","modified_gmt":"2018-05-14T14:05:48","slug":"otizm-alzheimera-karsi","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2014\/08\/01\/otizm-alzheimera-karsi","title":{"rendered":"Otizm Alzheimer\u2019a kar\u015f\u0131"},"content":{"rendered":"

Otizm belki de insanlar\u0131 Alzheimer hastal\u0131\u011f\u0131ndan koruyor olabilir. 17 Haziran\u2019da Medical Hypotheses<\/em> dergisinde yay\u0131mlanan makalede, bu konuda ortaya konan bilgiler payla\u015f\u0131ld\u0131. Ancak elbette do\u011frulu\u011funun kan\u0131tlanmas\u0131 i\u00e7in biliminsanlar\u0131n\u0131n daha pek \u00e7ok \u00e7al\u0131\u015fma yapmas\u0131 gerekecek.<\/p>\n

Wisconsin-Madison \u00dcniversitesi\u2019nden molek\u00fcler biyolog Cara Westmark\u2019a g\u00f6re, iki hastal\u0131k aras\u0131ndaki ba\u011flant\u0131 heyecan verici g\u00f6r\u00fcn\u00fcyor. Zira her iki hastal\u0131k da son on y\u0131lda say\u0131ca \u00e7ok b\u00fcy\u00fck art\u0131\u015f g\u00f6sterdi.<\/p>\n

Ara\u015ft\u0131rmay\u0131 y\u00fcr\u00fcten Harvard T\u0131p Fak\u00fcltesi\u2019nden Alvara Pascual-Leone ve Brown \u00dcniversitesi T\u0131p Fak\u00fcltesi\u2019nden Lindsay Oberman, otizmin Alzheimer\u2019i engelleyebilece\u011fi d\u00fc\u015f\u00fcncesinden hareket ettiler. Ara\u015ft\u0131rmac\u0131lar\u0131n her ikisi de, beyne gelen de\u011fi\u015fik uyar\u0131lara verilen yan\u0131t\u0131n beyin \u00fczerinde nas\u0131l bir de\u011fi\u015fiklik yaratt\u0131\u011f\u0131na (beynin plastisitesi) odakland\u0131. De\u011fi\u015fiklikler, beyin h\u00fccreleri aras\u0131nda g\u00fc\u00e7l\u00fc ba\u011flant\u0131lar olu\u015fmas\u0131 veya n\u00f6ral yolun yeniden d\u00f6\u015fenmesini sa\u011fl\u0131yordu. Daha \u00f6nceki \u00e7al\u0131\u015fmalar, Alzheimer hastalar\u0131nda d\u00fc\u015f\u00fck beyin plastisitesi oldu\u011funu; otistiklerde ise bunun y\u00fcksek d\u00fczeyde oldu\u011fu belirlenmi\u015fti.<\/p>\n

Fark\u0131 a\u00e7\u0131\u011fa \u00e7\u0131karabilmek i\u00e7in Pascual-Leone ve Oberman otizmin bir \u015fekli olan Asperger\u2019s sendromlu 35 hasta ile olmayan 35 ki\u015filik kontrol grubu \u00fczerinde transkranial magnetik stim\u00fclasyon tekni\u011fi denilen bir y\u00f6ntem uygulad\u0131lar. Burada motor kortekse d\u0131\u015fardan \u00e7ok hafif bir uyar\u0131 veriliyordu. Ortalama olarak Asperger\u2019s sendromlular\u0131n ellerinde meydana gelen yan\u0131t, olmayanlara g\u00f6re daha fazlayd\u0131 ve bu da y\u00fcksek beyin plastisitesi ile uyumluydu.<\/p>\n

Bu y\u00fckselmi\u015f beyin plastisitesi ya\u015fla azal\u0131yordu. \u00c7al\u0131\u015fmada, Asperger\u2019s olsun ya da olmas\u0131n beyin plastisitesi ya\u015fl\u0131larda, gen\u00e7lere g\u00f6re \u00e7ok daha azalm\u0131\u015ft\u0131. Ara\u015ft\u0131rmac\u0131lar\u0131n d\u00fc\u015f\u00fcncesine g\u00f6re \u00e7al\u0131\u015fmaya ba\u015fland\u0131\u011f\u0131nda ise y\u00fckselen plastisite, otizm-Alzheimer ba\u011flant\u0131s\u0131 bulunan ki\u015filerde hi\u00e7bir zaman \u00e7ok d\u00fc\u015f\u00fck seviyelere inmeyecekti.<\/p>\n

\u00c7al\u0131\u015fmaya kat\u0131lan Asperger\u2019s sendromlular\u0131n IQ\u2019lar\u0131 normaldi. Ara\u015ft\u0131rmac\u0131lar otizmin di\u011fer formlar\u0131nda ve \u00f6zellikle de entelekt\u00fcel yetersizlik olan bi\u00e7imlerinde nas\u0131l bir yan\u0131t alacaklar\u0131n\u0131 bilmiyor. Harvard ba\u011flant\u0131l\u0131 hastanelerin kay\u0131tlar\u0131nda 55 ya\u015f \u00fcst\u00fc Alzheimer ve otizmin herhangi bir tipini birlikte g\u00f6steren hasta kayd\u0131 bulunamad\u0131. Ara\u015ft\u0131rma sonu\u00e7lar\u0131 olgu say\u0131s\u0131 10\u2019un alt\u0131na d\u00fc\u015ft\u00fc\u011f\u00fcnden, genel sonu\u00e7lar\u0131 da ge\u00e7ersiz k\u0131laca\u011f\u0131ndan bu tip olgular\u0131n \u00e7ok nadir ya da hi\u00e7 olmad\u0131\u011f\u0131 kanaatine var\u0131ld\u0131.<\/p>\n

Pascual-Leone\u2019ye g\u00f6re bu \u201colmama\u201d halinin biyolojik olmayan gerek\u00e7elerle a\u00e7\u0131klanmas\u0131 m\u00fcmk\u00fcn g\u00f6r\u00fcn\u00fcyor. Y\u0131llar \u00f6nce doktorlar birine semptomlar\u0131 dikkate almaks\u0131z\u0131n otizm tan\u0131s\u0131 koyabiliyordu, ya da eri\u015fkin ya\u015flarda otizm tan\u0131s\u0131 \u00e7ok az konabiliyordu. Westmark\u2019a g\u00f6re bir di\u011fer olas\u0131l\u0131k da \u00f6zellikle azalm\u0131\u015f entelekt\u00fcel yetileri olan otistiklerde yakla\u015fan Alzheimer hastal\u0131\u011f\u0131n\u0131n belirtilerini fark edebilmenin neredeyse imk\u00e2ns\u0131z olmas\u0131yd\u0131.<\/p>\n

Ara\u015ft\u0131rmac\u0131lara g\u00f6re otizmin koruyucu olmas\u0131 \u00e7ok yeni bir fikir olabilir; ancak ba\u015fka birilerinin de tam tersi bir g\u00f6r\u00fc\u015f\u00fc ortaya at\u0131p ara\u015ft\u0131rmalar yapabilece\u011fini d\u00fc\u015f\u00fcn\u00fcyorlar. Asl\u0131nda bu ara\u015ft\u0131rmalar ve di\u011ferleri, otizmin kesin bir formunda hastalar\u0131n Alzheimer riskinin artt\u0131\u011f\u0131n\u0131 bile ima eder durumdad\u0131r. Zira bu hastalarda Alzheimer\u2019a neden oldu\u011fu belirlenen amiloid beta protein fragman d\u00fczeyleri de\u011fi\u015fik d\u00fczeylerde bulunmu\u015ftur.<\/p>\n

Pascual-Leone\u2019ye g\u00f6re yap\u0131lacak daha fazla \u00e7al\u0131\u015fma, bu iki hastal\u0131k aras\u0131ndaki ili\u015fkiye bir d\u00fczen getirecektir. \u201cUmar\u0131z bulunan ba\u011f her iki hastal\u0131\u011f\u0131n da semptomlar\u0131n\u0131 azaltmada etkili olabilecektir\u201d diyor \u00e7al\u0131\u015fmay\u0131 yapan ekip. Yine de egzersiz, ila\u00e7lar ve beyin e\u011fitimleri beyin plastisitesini de\u011fi\u015ftirmede temel bir potansiyel ta\u015f\u0131yor.<\/p>\n","protected":false},"excerpt":{"rendered":"

Otizm belki de insanlar\u0131 Alzheimer hastal\u0131\u011f\u0131ndan koruyor olabilir. 17 Haziran\u2019da Medical Hypotheses dergisinde yay\u0131mlanan makalede, bu konuda ortaya konan bilgiler payla\u015f\u0131ld\u0131. Ancak elbette do\u011frulu\u011funun kan\u0131tlanmas\u0131 i\u00e7in biliminsanlar\u0131n\u0131n daha pek \u00e7ok \u00e7al\u0131\u015fma yapmas\u0131 gerekecek. Wisconsin-Madison \u00dcniversitesi\u2019nden molek\u00fcler biyolog Cara Westmark\u2019a g\u00f6re, iki hastal\u0131k aras\u0131ndaki ba\u011flant\u0131 heyecan verici g\u00f6r\u00fcn\u00fcyor. Zira her iki hastal\u0131k da son on y\u0131lda […]<\/p>\n","protected":false},"author":42,"featured_media":25445,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[163,19,33],"tags":[982,981,425],"class_list":["post-12010","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-126-sayi","category-bilim-gundemi","category-saglik-bilimleri","tag-alzheimer","tag-otizm","tag-saglik"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t