Ara\u015ft\u0131rmac\u0131lar, iyile\u015fmeyen k\u0131r\u0131klarda kullan\u0131lan kemik nakil sisteminin uzun s\u00fcreli hastane bak\u0131m\u0131n\u0131, sakatl\u0131klar\u0131 ve \u00f6nemli miktardaki masraflar\u0131n\u0131 azaltmaya yard\u0131mc\u0131 olabilecek alternatif bir y\u00f6ntem geli\u015ftirdi. Her y\u0131l y\u00fcz binlerce k\u0131r\u0131k kemik d\u00fczg\u00fcn bir \u015fekilde iyile\u015femiyor, sonu\u00e7 olarak kaynayamayan k\u0131r\u0131klar olu\u015fuyor ve d\u00fcnyada bu t\u00fcr zorlu hasarlar\u0131 tedavi etmek i\u00e7in her y\u0131l 2 milyondan fazla kemik nakli ger\u00e7ekle\u015fiyor.<\/p>\n
Hastalardan canl\u0131 kemi\u011fi almak genelde ac\u0131 verici ve doku bankalar\u0131ndan al\u0131nan ba\u011f\u0131\u015flanm\u0131\u015f nakiller \u00e7o\u011funlukla kayna\u015fmay\u0131 ger\u00e7ekle\u015ftiremiyor. Maxim Bez ve arkada\u015flar\u0131, FDA taraf\u0131ndan onaylanm\u0131\u015f ultrason ve mikrokabarc\u0131klarla, iki ad\u0131ml\u0131 gen terapi y\u00f6ntemini ke\u015ffettiler; tedavi 8 hafta i\u00e7inde domuzlardaki kaynamam\u0131\u015f k\u0131r\u0131klar\u0131n tamamen iyile\u015fmesini sa\u011flad\u0131.<\/p>\n
\u0130lk olarak ara\u015ft\u0131rmac\u0131lar \u00f6nc\u00fc kemik h\u00fccresi ni\u015fini kar\u015f\u0131lamay\u0131 sa\u011flamak i\u00e7in k\u0131r\u0131\u011f\u0131n oldu\u011fu alana kolajen iskelesi yerle\u015ftirdiler. Sonra, kemik b\u00fcy\u00fcme fakt\u00f6rl\u00fc genetik materyal ile kar\u0131\u015ft\u0131r\u0131lm\u0131\u015f mikrokabarc\u0131klar enjekte ettiler. Ultrason \u00e7ubu\u011fundan gelen ses titre\u015fimleri \u00f6nc\u00fc h\u00fccreleri uyararak b\u00fcy\u00fcme fakt\u00f6r\u00fc i\u00e7eren DNA\u2019y\u0131 almas\u0131n\u0131 ve b\u00f6ylelikle kemik geli\u015fimini canland\u0131rmas\u0131n\u0131 sa\u011flad\u0131.<\/p>\n
Y\u00fcklerini iletmek i\u00e7in viral vekt\u00f6rleri (vir\u00fcsler genomun i\u00e7ine kal\u0131c\u0131 olarak yerle\u015febilir ve daha sonra kanseri te\u015fvik edebilir veya \u00f6ld\u00fcr\u00fcc\u00fc ba\u011f\u0131\u015f\u0131kl\u0131k tepkilerini ortaya \u00e7\u0131karabilir) kullanan di\u011fer gen terapilerinin aksine, ultrason ve mikrokabarc\u0131klar kayda de\u011fer bir enflamasyona neden olmad\u0131 ve enjekte edilen genin ifadesi 10 g\u00fcn sonra saptanmad\u0131.<\/p>\n
Bu tekni\u011fin, minimal invazif, g\u00fcvenli ve alt\u0131n-standartl\u0131 nakil y\u00f6ntemiyle k\u0131yaslanabilecek kadar g\u00fc\u00e7l\u00fc oldu\u011fu ve eksiksiz kemik iyile\u015fimini te\u015fvik etti\u011fi kan\u0131tlanm\u0131\u015f oldu. Bez ve arkada\u015flar\u0131, sistemlerinin geli\u015ftirilmesiyle bir\u00e7ok farkl\u0131 doku m\u00fchendisli\u011fi uygulamalar\u0131nda kullan\u0131labilme potansiyeli oldu\u011funu s\u00f6yl\u00fcyorlar. Y\u00f6ntemin nas\u0131l \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131 g\u00f6steren video, \u015fu adresten izlenebilir: https:\/\/goo.gl\/gVb2xb<\/p>\n","protected":false},"excerpt":{"rendered":"
Ara\u015ft\u0131rmac\u0131lar, iyile\u015fmeyen k\u0131r\u0131klarda kullan\u0131lan kemik nakil sisteminin uzun s\u00fcreli hastane bak\u0131m\u0131n\u0131, sakatl\u0131klar\u0131 ve \u00f6nemli miktardaki masraflar\u0131n\u0131 azaltmaya yard\u0131mc\u0131 olabilecek alternatif bir y\u00f6ntem geli\u015ftirdi. Her y\u0131l y\u00fcz binlerce k\u0131r\u0131k kemik d\u00fczg\u00fcn bir \u015fekilde iyile\u015femiyor, sonu\u00e7 olarak kaynayamayan k\u0131r\u0131klar olu\u015fuyor ve d\u00fcnyada bu t\u00fcr zorlu hasarlar\u0131 tedavi etmek i\u00e7in her y\u0131l 2 milyondan fazla kemik nakli ger\u00e7ekle\u015fiyor. […]<\/p>\n","protected":false},"author":870,"featured_media":12772,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[721,19,21],"tags":[197,272,431,306],"class_list":["post-12771","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-160-sayi","category-bilim-gundemi","category-biyoloji","tag-biyoloji","tag-dna","tag-gen","tag-hucre"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/12771","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/870"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=12771"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/12771\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media\/12772"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=12771"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=12771"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=12771"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}