Romal\u0131 \u015fair Juvenal 2000 y\u0131l \u00f6nce, \u201cSa\u011flam v\u00fccutta sa\u011flam zihin i\u00e7in dilekte bulunmal\u0131y\u0131z. Daima sa\u011flam bir kafan ve sa\u011flam bir v\u00fccudun olmas\u0131 i\u00e7in dua et\u201d diye yazm\u0131\u015ft\u0131. Johns Hopkins \u00dcniversitesi\u2019nde bir grup ara\u015ft\u0131rmac\u0131, beyin ve kalp sa\u011fl\u0131\u011f\u0131na destek olan tek bir protein tespit ettiler.
\nBiliminsanlar\u0131, daha \u00f6nceden de haf\u0131zay\u0131 geli\u015ftirdi\u011fi, n\u00f6ral kan ak\u0131m\u0131n\u0131 artt\u0131rd\u0131\u011f\u0131 ve adeta do\u011fal bir antidepresan gibi davrand\u0131\u011f\u0131 bilinen ve BDNF (brain derived n\u00f6rotrofik fakt\u00f6r) olarak an\u0131lan proteinin, ayn\u0131 zamanda kalbin d\u00fczenli at\u0131m\u0131na da yard\u0131mc\u0131 oldu\u011funu buldular. Ara\u015ft\u0131rmac\u0131lar, yeni bulgular\u0131n, son y\u0131llarda \u00e7ok\u00e7a konu\u015fulan depresyon-kalp hastal\u0131\u011f\u0131 ba\u011flant\u0131s\u0131n\u0131 a\u00e7\u0131klamaya yard\u0131mc\u0131 olabilece\u011fini ve bunun da yeni kalp yetmezli\u011fi tedavilerine \u00f6nc\u00fcl\u00fck edebilece\u011fini belirtiyorlar.
\nBDNF beyin taraf\u0131ndan \u00fcretilir ve t\u0131pk\u0131 bir b\u00fcy\u00fcme fakt\u00f6r\u00fc gibi yeni sinir h\u00fccrelerinin olu\u015fumu ve t\u00fcm sinir sistemini kaplayan kan damar\u0131 a\u011f\u0131n\u0131n beslenmesini sa\u011flar. Pek \u00e7ok ara\u015ft\u0131rma, BDNF yoklu\u011fuyla do\u011fan farelerin do\u011fumdan k\u0131sa bir s\u00fcre sonra n\u00f6rolojik hastal\u0131klara ba\u011fl\u0131 olarak \u00f6ld\u00fc\u011f\u00fcn\u00fc g\u00f6stermi\u015ftir. Ayn\u0131 \u015fekilde BDNF eksikli\u011fiyle do\u011fan insanlarda da depresyon, demans, \u015fizofreni, obsessif komp\u00fclsif bozukluk ve Huntington hastal\u0131\u011f\u0131 gibi n\u00f6rodejeneratif hastal\u0131klar\u0131n fazlaca g\u00f6r\u00fclebildi\u011fi \u00f6ng\u00f6r\u00fclm\u00fc\u015ft\u00fc.
\nVerilen BDNF\u2019nin kalbe hizmet eden sinirlerin geli\u015fimine de fayda sa\u011flad\u0131\u011f\u0131 belirlenince, Johns Hopkins \u00dcniversitesi T\u0131p Fak\u00fcltesi\u2019nde \u00e7al\u0131\u015fan Dr. Ning Feng ve ekibi, bu proteinin kalp fonksiyonlar\u0131 \u00fczerindeki etkisini ara\u015ft\u0131rmak istedi. Ekip ilk\u00f6nce farelerden izole edilen kalp kas\u0131 h\u00fccrelerini BDNF ile adeta y\u0131kad\u0131 ve t\u0131pk\u0131 tam bir kalp at\u0131m\u0131 gibi h\u00fccrelerin kas\u0131l\u0131p gev\u015femeye ba\u015flad\u0131\u011f\u0131n\u0131 g\u00f6rd\u00fc.
\nAra\u015ft\u0131rmac\u0131lar deneyi, kalbi zay\u0131f olan farelerin kalp kas\u0131 h\u00fccrelerinde de yapt\u0131 ve BDNF varl\u0131\u011f\u0131na ra\u011fmen kas\u0131l\u0131p gev\u015femenin bunlarda pek de canl\u0131 olmad\u0131\u011f\u0131n\u0131 fark ettiler. Bu bulgu, \u00e7al\u0131\u015fmada kullan\u0131lan h\u00fccrelerdeki bir eksikli\u011fin, var olan BDNF\u2019ye yan\u0131t\u0131 engelledi\u011fini g\u00f6steriyordu. Kas\u0131l\u0131p gev\u015femeyi sa\u011fl\u0131kl\u0131 bi\u00e7imde olu\u015fturmak i\u00e7in BDNF\u2019nin h\u00fccre i\u00e7ine girmesini sa\u011flayan ve h\u00fccre y\u00fczeyinde resept\u00f6r olarak g\u00f6rev alan bir molek\u00fcl (TrkB) oldu\u011fu anla\u015f\u0131ld\u0131. Kalbi zay\u0131f olan farelerde TrkB\u2019nin biraz daha farkl\u0131 bir formu vard\u0131 veya BDNF ile TrkB\u2019nin aras\u0131ndaki sinyal engelleniyordu.
\nAra\u015ft\u0131rmac\u0131lar\u0131n bir sonraki bulgusu, TrkB\u2019sinde beslenme yetersizli\u011fi olan farelerde kalp yetmezli\u011fi belirlenmesi oldu. Farelerin kalp kas\u0131lmalar\u0131 yetersizdi, kan\u0131 pompalama yetenekleri azalm\u0131\u015ft\u0131 ve her at\u0131mdan sonraki gev\u015feme hareketi epeyce ge\u00e7 olu\u015fmaktayd\u0131.
\nB\u00fct\u00fcn bulgular bir araya getirildi\u011finde, BDNF yolundaki aksama, resept\u00f6r d\u00fczeyinde kalp i\u00e7i sinyal mekanizmas\u0131n\u0131 bozarak kimyasal tetikleyicilerin kusuruna sebep oluyor ve sonu\u00e7ta yetersiz kardiyak aktivite olu\u015fuyordu. Ara\u015ft\u0131rmay\u0131 yay\u0131mlayanlardan biri olan Dr. Nazareno Paolocci\u2019ye g\u00f6re, BDNF ileti\u015fimindeki bozulmalar, kemoterapi alan baz\u0131 kanser hastalar\u0131nda da kardiyak yetmezli\u011fe sebep olabiliyordu. Zira kemoterap\u00f6tik ajanlar\u0131n i\u00e7inde muhtemelen TrkB\u2019nin de aralar\u0131nda bulundu\u011fu t\u00fcm\u00f6r\u00fcn geli\u015fimini durdurmaya y\u00f6nelik bir dizi \u201cb\u00fcy\u00fcme fakt\u00f6r\u00fc engelleyici\u201d resept\u00f6rler mevcut.
\nPaolocci\u2019ye g\u00f6re BDNF-TrkB yolunu hedef alan \u00e7al\u0131\u015fmalar belki de kalp hastal\u0131klar\u0131n\u0131n kesin tedavisinde \u00f6nemli bir yol a\u00e7acak. Hatta BDNF\u2019yi taklit eden bir ila\u00e7 halihaz\u0131rda bir k\u0131s\u0131m inmeli ve n\u00f6rolojik hastal\u0131\u011f\u0131 olan hastalarda denenmi\u015f ve faydal\u0131 olabilmi\u015ftir. \u201cBDNF yetersizli\u011fi belki tam olarak olgunla\u015fm\u0131\u015f bir hastal\u0131k yaratmaz ama \u2018k\u0131r\u0131k bir kalbe\u2019 giden yolu a\u00e7abilir.\u201d
\nPaolocci, hen\u00fcz kesin deneysel kan\u0131tlar olmamakla beraber, k\u00f6t\u00fc diyet ve hareketsiz ya\u015fam tarz\u0131n\u0131n BDNF dola\u015f\u0131m\u0131n\u0131 azaltt\u0131\u011f\u0131n\u0131 veya TrkB resept\u00f6r fonksiyonlar\u0131n\u0131 de\u011fi\u015ftirebilece\u011fini de belirtiyor.<\/p>\n
\u00c7eviren: Dr. Ebru Oktay<\/strong><\/p>\n Kaynak:<\/strong> http:\/\/kisalt.com\/abf<\/p>\n","protected":false},"excerpt":{"rendered":" Romal\u0131 \u015fair Juvenal 2000 y\u0131l \u00f6nce, \u201cSa\u011flam v\u00fccutta sa\u011flam zihin i\u00e7in dilekte bulunmal\u0131y\u0131z. Daima sa\u011flam bir kafan ve sa\u011flam bir v\u00fccudun olmas\u0131 i\u00e7in dua et\u201d diye yazm\u0131\u015ft\u0131. Johns Hopkins \u00dcniversitesi\u2019nde bir grup ara\u015ft\u0131rmac\u0131, beyin ve kalp sa\u011fl\u0131\u011f\u0131na destek olan tek bir protein tespit ettiler. Biliminsanlar\u0131, daha \u00f6nceden de haf\u0131zay\u0131 geli\u015ftirdi\u011fi, n\u00f6ral kan ak\u0131m\u0131n\u0131 artt\u0131rd\u0131\u011f\u0131 ve […]<\/p>\n","protected":false},"author":1,"featured_media":1733,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19,231],"tags":[],"class_list":["post-1732","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","category-molekuler-biyoloji-ve-genetik"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/1732","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=1732"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/1732\/revisions"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=1732"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=1732"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=1732"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}