Yakla\u015f\u0131k 2 milyon y\u0131l \u00f6nce, di\u011fer primatlardan fakl\u0131la\u015fm\u0131\u015f insanda genetik bir de\u011fi\u015fim olu\u015ftu; bu de\u011fi\u015fim k\u0131rm\u0131z\u0131 eti bir sa\u011fl\u0131k riski haline getirmesine ra\u011fmen, insan\u0131n hastal\u0131klardan korunmas\u0131n\u0131 sa\u011flad\u0131.<\/p>\n
\u0130nsan evriminin bug\u00fcn gelinen ve bilinen noktas\u0131nda, \u015feker geni olan Neu5Gc\u2019nin sentezini sa\u011flayan CMAH olarak adland\u0131rd\u0131\u011f\u0131m\u0131z gen kayboldu. Bu \u015feker, k\u0131rm\u0131z\u0131 et, baz\u0131 bal\u0131klar ve mand\u0131ra \u00fcr\u00fcnlerinde bulunuyor. \u0130nsan bu genin bulundu\u011fu hayvan\u0131 yedi\u011finde, v\u00fccudunda bu yabanc\u0131 \u015fekere kar\u015f\u0131 ba\u011f\u0131\u015f\u0131kl\u0131k yan\u0131t\u0131 olu\u015fuyor ve bu da inflamasyon, artrit ve hatta kansere yol a\u00e7\u0131yor.<\/p>\n
Reno Nevada \u00dcniversitesi\u2019nde David Alverez- Ponce ve ekibi, aktif CMAH geni ta\u015f\u0131yan 322 hayvan\u0131n genom dizisini analiz etti. 322 hayvandan al\u0131nan veriden bir genom a\u011fac\u0131 olu\u015fturdu. Bu a\u011fa\u00e7ta, hayvanlar\u0131n evrimsel tarihinde CMAH geninin ne zaman i\u015flevsizle\u015fti\u011fi ya da \u201ckapand\u0131\u011f\u0131\u201d belirlenmi\u015fti. Bu bilgi, neden baz\u0131 t\u00fcrlerde h\u00e2l\u00e2 aktif CMAH geninin var olup, benzer t\u00fcrlerde olmad\u0131\u011f\u0131n\u0131 a\u00e7\u0131klamak a\u00e7\u0131s\u0131ndan \u00f6nemliydi.<\/p>\n
Alvarez- Ponce\u2019nin laboratuvar\u0131 yapt\u0131klar\u0131 az say\u0131daki bal\u0131k ara\u015ft\u0131rmas\u0131nda Neu5Gc d\u00fczeylerinin insan sa\u011fl\u0131\u011f\u0131nda endi\u015felenecek bir durum yaratmad\u0131\u011f\u0131n\u0131 saptamalar\u0131na ra\u011fmen, \u201chavyar\u201d olarak bilinen bal\u0131k yumurtas\u0131nda belirgin bir y\u00fckseklik tespit etmi\u015fler.<\/p>\n
Diyet d\u0131\u015f\u0131nda CMAH geni organ nakillerinde de \u00f6nem kazan\u0131r. CMAH geni aktif bir hayvan\u0131n organ ya da dokusu insana verildi\u011finde, insanda bu gen olmad\u0131\u011f\u0131ndan v\u00fccutta nakile red yan\u0131t\u0131 olu\u015facakt\u0131r. \u0130nsan\u0131n evrim s\u00fcrecinde CMAH geninin i\u015flevini kaybetmesi onu ayn\u0131 zamanda pek \u00e7ok patojenden korumu\u015f olabilir. \u00d6rne\u011fin bu \u015fekere ihtiya\u00e7 duyan belirli bir s\u0131tma tipi di\u011fer primatlarda hastal\u0131k yaparken insanda yapamaz.<\/p>\n
CMAH geninin oldu\u011fu hayvanlar\u0131n belirlenmesi, insanlar\u0131n neleri yiyip yiyemeyece\u011fi, hangi hayvan\u0131n \u0131s\u0131r\u0131klar\u0131ndan ka\u00e7\u0131nmas\u0131 gerekti\u011fi gibi bilgileri de sa\u011flayacakt\u0131r. K\u0131rm\u0131z\u0131 etin d\u00fc\u015f\u00fck d\u00fczeyde t\u00fcketimi sorun olmayabilir. E\u011fer hayvanlar CMAH geni ta\u015f\u0131m\u0131yorsa, b\u00fcy\u00fck olas\u0131l\u0131kla Neu5Gc\u2019nin \u00f6nc\u00fcs\u00fc olan Neu5Ac ba\u011flant\u0131l\u0131 patojenler ta\u015f\u0131rlar ki, bu da insanlar\u0131 etkileyebilir.<\/p>\n
Bu \u00e7al\u0131\u015fma, beslenme, genetik ve ila\u00e7 geli\u015ftirme anlam\u0131nda can al\u0131c\u0131 bir geli\u015fmeye yol a\u00e7acak gibi g\u00f6r\u00fcnmektedir. \u00c7al\u0131\u015fma, belli hastal\u0131klar\u0131n formlar\u0131 ve yay\u0131lmalar\u0131n\u0131 engelleyecek m\u00fccadele metotlar\u0131n\u0131 bulmada da yard\u0131mc\u0131 olabilir.<\/p>\n","protected":false},"excerpt":{"rendered":"
Yakla\u015f\u0131k 2 milyon y\u0131l \u00f6nce, di\u011fer primatlardan fakl\u0131la\u015fm\u0131\u015f insanda genetik bir de\u011fi\u015fim olu\u015ftu; bu de\u011fi\u015fim k\u0131rm\u0131z\u0131 eti bir sa\u011fl\u0131k riski haline getirmesine ra\u011fmen, insan\u0131n hastal\u0131klardan korunmas\u0131n\u0131 sa\u011flad\u0131. \u0130nsan evriminin bug\u00fcn gelinen ve bilinen noktas\u0131nda, \u015feker geni olan Neu5Gc\u2019nin sentezini sa\u011flayan CMAH olarak adland\u0131rd\u0131\u011f\u0131m\u0131z gen kayboldu. Bu \u015feker, k\u0131rm\u0131z\u0131 et, baz\u0131 bal\u0131klar ve mand\u0131ra \u00fcr\u00fcnlerinde bulunuyor. […]<\/p>\n","protected":false},"author":42,"featured_media":17955,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2147,19,21,32,231],"tags":[272,292,1049],"class_list":["post-17954","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-167-sayi","category-bilim-gundemi","category-biyoloji","category-evrim","category-molekuler-biyoloji-ve-genetik","tag-dna","tag-genetik","tag-insanin-evrimi"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/17954","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/42"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=17954"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/17954\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media\/17955"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=17954"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=17954"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=17954"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}