Biliminsanlar\u0131 evrim s\u00fcrecinde tek genlerin mutasyon ge\u00e7irme bi\u00e7imine geni\u015f\u00e7e hakim olduklar\u0131ndan, bunun konak organizma i\u00e7in bir uygunluk maliyeti veya yarara sahip olabilece\u011fini d\u00fc\u015f\u00fcn\u00fcyorlard\u0131. Bununla birlikte genler \u00e7o\u011fu kez karma\u015f\u0131k d\u00fczenleyici a\u011flar i\u00e7inde g\u00f6m\u00fcl\u00fcd\u00fcr. Evrimde bu gen a\u011flar\u0131n\u0131n rol\u00fc hen\u00fcz pek ayd\u0131nlat\u0131lamam\u0131\u015ft\u0131r.
\nYale ara\u015ft\u0131rmac\u0131lar\u0131, bir do\u011fal gen a\u011f\u0131n\u0131n faaliyetinin nas\u0131l geli\u015fti\u011fini sistematik olarak de\u011ferlendirdi ve \u015fa\u015f\u0131rt\u0131c\u0131 sonu\u00e7lar buldu. A\u011flardaki genler promotor olarak adland\u0131r\u0131lan genetik materyal taraf\u0131ndan d\u00fczenlenir. Yale ekibi kombinasyon y\u00f6ntemiyle \u015feker metabolizasyon a\u011f\u0131n\u0131n promotorlar\u0131n\u0131 iki maya t\u00fcr\u00fc aras\u0131nda yer de\u011fi\u015ftirdi ve sonra d\u00fczenli olarak maya h\u00fccreleri \u00fczerindeki etkileri analiz ettiler. Bir negatif geri besleme d\u00f6ng\u00fcs\u00fcne arac\u0131l\u0131k eden GAL80 promotorunun, esasen bozulmu\u015f a\u011f faaliyetleri ve maya h\u00fccrelerinin uygunluk profilleriyle yer de\u011fi\u015ftirdi\u011fini buldular.
\nMolek\u00fcler, h\u00fccresel ve geli\u015fimsel biyolog, Bat\u0131 Kamp\u00fcs\u00fc Enstit\u00fcs\u00fc\u2019nde Sistem Biyolojisi Ara\u015ft\u0131rmac\u0131s\u0131 ve bu \u00e7al\u0131\u015fman\u0131n k\u0131demli yazar\u0131 Prof. Murat Acar: \u201cGen a\u011f\u0131 seviyesinde evrimin nas\u0131l olu\u015ftu\u011fu hakk\u0131nda s\u0131n\u0131rl\u0131 deneysel kan\u0131ta sahibiz\u201d diyor. Negatif geri besleme d\u00fczenlenmesin t\u00fcrler aras\u0131 a\u011f etkinli\u011fi farkl\u0131l\u0131klar\u0131 \u00fczerinde oynad\u0131\u011f\u0131 rol\u00fcn ayd\u0131nlat\u0131lmas\u0131n\u0131 \u00f6nemli buluyorlar. Acar\u2019a g\u00f6re nicel sistemler biyolojisi yakla\u015f\u0131mlar\u0131yla, gen a\u011flar\u0131n\u0131n evrimini \u00e7al\u0131\u015fmak, antibiyotik-direnci gibi halk sa\u011fl\u0131k problemlerine kar\u015f\u0131 sava\u015f\u0131m\u0131m\u0131zda gerekli anahtar ilkelerin ortaya \u00e7\u0131kar\u0131lmas\u0131na yard\u0131mc\u0131 olabilir.<\/p>\n
\u00c7eviren: Semih \u0130\u015fba\u015f Kaynak:<\/strong> http:\/\/news.yale.edu\/2015\/02\/11\/research-news-evolution-natural-gene-network-explored-yale-researchers#.VNt6HjanO9Q.facebook<\/p>\n","protected":false},"excerpt":{"rendered":" Biliminsanlar\u0131 evrim s\u00fcrecinde tek genlerin mutasyon ge\u00e7irme bi\u00e7imine geni\u015f\u00e7e hakim olduklar\u0131ndan, bunun konak organizma i\u00e7in bir uygunluk maliyeti veya yarara sahip olabilece\u011fini d\u00fc\u015f\u00fcn\u00fcyorlard\u0131. Bununla birlikte genler \u00e7o\u011fu kez karma\u015f\u0131k d\u00fczenleyici a\u011flar i\u00e7inde g\u00f6m\u00fcl\u00fcd\u00fcr. Evrimde bu gen a\u011flar\u0131n\u0131n rol\u00fc hen\u00fcz pek ayd\u0131nlat\u0131lamam\u0131\u015ft\u0131r. Yale ara\u015ft\u0131rmac\u0131lar\u0131, bir do\u011fal gen a\u011f\u0131n\u0131n faaliyetinin nas\u0131l geli\u015fti\u011fini sistematik olarak de\u011ferlendirdi ve \u015fa\u015f\u0131rt\u0131c\u0131 […]<\/p>\n","protected":false},"author":1,"featured_media":2010,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19,21,231],"tags":[],"class_list":["post-2009","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","category-biyoloji","category-molekuler-biyoloji-ve-genetik"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/2009","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=2009"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/2009\/revisions"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=2009"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=2009"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=2009"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n\u0130stanbul \u00dcnv. Biyoloji B\u00f6l\u00fcm\u00fc<\/strong><\/em><\/p>\n