\u00c7inli biliminsanlar\u0131, olgun somatik h\u00fccreleri iki kimyasaldan olu\u015fan bir kokteyl ile uyararak bu somatik h\u00fccrelerin pluripotent k\u00f6k h\u00fccrelere (somatik h\u00fccrelerin farkl\u0131la\u015fmadan \u00f6nceki haline) geri d\u00f6n\u00fc\u015fmesini sa\u011flayarak k\u00f6k h\u00fccre yaratma konusunda \u00e7\u0131\u011f\u0131r a\u00e7t\u0131lar.<\/p>\n
\u00c7in Bilimler Akademisi\u2019nin Guangzhou Biyot\u0131p ve Sa\u011fl\u0131k Enstit\u00fcs\u00fc\u2019ndeki biliminsanlar\u0131 taraf\u0131ndan y\u00fcr\u00fct\u00fclen \u00e7al\u0131\u015fman\u0131n \u00f6nc\u00fc ara\u015ft\u0131rmac\u0131s\u0131 Pei Duanqing, bu yeni y\u00f6ntemin, h\u00fccrelerin kaderini anlamalar\u0131na yard\u0131mc\u0131 olaca\u011f\u0131n\u0131 ve rejeneratif t\u0131p alan\u0131nda uygulanabilece\u011fini s\u00f6yledi.<\/p>\n
D\u00fcnyan\u0131n d\u00f6rt bir yan\u0131ndaki biliminsanlar\u0131, bir kertenkele t\u00fcr\u00fc olan gekonun kuyru\u011funu yeniden b\u00fcy\u00fctebilmesi gibi, insanlar\u0131n hastal\u0131k veya yaralanma nedeniyle kaybedilen doku veya organlar\u0131 yeniden geli\u015ftirmesini sa\u011flayacak \u201canahtarlar\u201d\u0131 ar\u0131yor.<\/p>\n
K\u00f6k h\u00fccreler, di\u011fer h\u00fccre t\u00fcrlerine d\u00f6n\u00fc\u015fme potansiyelini korurken kendi kendini yenileyebilen veya \u00e7o\u011faltabilen bir h\u00fccre t\u00fcr\u00fcd\u00fcr. Kan, kalp, kemik, deri, kas ve beyin h\u00fccrelerine veya v\u00fccudumuzun ba\u015fka bir b\u00f6lgesinin h\u00fccrelerine d\u00f6n\u00fc\u015febilirler. Bunlar de\u011ferli ara\u015ft\u0131rma ara\u00e7lar\u0131d\u0131r ve gelecekte \u00e7ok say\u0131da rahats\u0131zl\u0131\u011f\u0131 tedavi etmek i\u00e7in kullan\u0131labileceklerdir.<\/p>\n
Ama yeteri kadar k\u00f6k h\u00fccreye nas\u0131l sahip olabiliriz? Biliminsanlar\u0131, somatik h\u00fccreleri, k\u00f6k h\u00fccrelere d\u00f6n\u00fc\u015ft\u00fcrmek i\u00e7in farkl\u0131 yakla\u015f\u0131mlar denediler. Japon biliminsan\u0131, Nobel \u00d6d\u00fcll\u00fc Shinya Yamanaka, uyar\u0131lm\u0131\u015f k\u00f6k h\u00fccreleri \u00fcretmek i\u00e7in ta\u015f\u0131y\u0131c\u0131 olarak bir vir\u00fcs kullanm\u0131\u015ft\u0131r, ancak bu y\u00f6ntemin kansere neden olma riskini y\u00fckseltti\u011fi d\u00fc\u015f\u00fcn\u00fclmektedir.<\/p>\n
\u00c7inli biliminsanlar\u0131 be\u015f y\u0131l boyunca daha verimli, daha basit ve daha g\u00fcvenli bir kimyasal ind\u00fcksiyon y\u00f6ntemi geli\u015ftirdiler. Ara\u015ft\u0131rma ekibinin bir \u00fcyesi olan Liu Jing, \u201cH\u00fccrelerin kaderi, h\u00fccrelerin \u00e7ekirde\u011findeki kromatin yap\u0131s\u0131 taraf\u0131ndan belirlenir\u201d diyor ve \u015f\u00f6yle devam ediyor, \u201cKromatin yap\u0131s\u0131n\u0131 k\u00fc\u00e7\u00fck molek\u00fcler kimyasallar kullanarak somatik h\u00fccreleri yeniden programlamakta, somatik h\u00fccreyi k\u00f6k h\u00fccreye d\u00f6n\u00fc\u015ft\u00fcrmek i\u00e7in manip\u00fcle ediyoruz.\u2019\u2019<\/p>\n
Liu, kimyasal s\u0131v\u0131n\u0131n i\u00e7indeki \u00e7e\u015fitli somatik h\u00fccrelerin, di\u011fer y\u00f6ntemlerle yeniden programlanmas\u0131 zor olan hepatik h\u00fccre de dahil olmak \u00fczere pluripotent k\u00f6k h\u00fccrelerine d\u00f6n\u00fc\u015fmesine neden olabilece\u011fini de ekliyor. \u00c7al\u0131\u015fma, Cell Stem Cell<\/em>\u2019in son say\u0131s\u0131nda yay\u0131mland\u0131.<\/p>\n","protected":false},"excerpt":{"rendered":" \u00c7inli biliminsanlar\u0131, olgun somatik h\u00fccreleri iki kimyasaldan olu\u015fan bir kokteyl ile uyararak bu somatik h\u00fccrelerin pluripotent k\u00f6k h\u00fccrelere (somatik h\u00fccrelerin farkl\u0131la\u015fmadan \u00f6nceki haline) geri d\u00f6n\u00fc\u015fmesini sa\u011flayarak k\u00f6k h\u00fccre yaratma konusunda \u00e7\u0131\u011f\u0131r a\u00e7t\u0131lar. \u00c7in Bilimler Akademisi\u2019nin Guangzhou Biyot\u0131p ve Sa\u011fl\u0131k Enstit\u00fcs\u00fc\u2019ndeki biliminsanlar\u0131 taraf\u0131ndan y\u00fcr\u00fct\u00fclen \u00e7al\u0131\u015fman\u0131n \u00f6nc\u00fc ara\u015ft\u0131rmac\u0131s\u0131 Pei Duanqing, bu yeni y\u00f6ntemin, h\u00fccrelerin kaderini anlamalar\u0131na yard\u0131mc\u0131 […]<\/p>\n","protected":false},"author":746,"featured_media":23644,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19,21,231],"tags":[424,2908,2907,2906],"class_list":["post-23643","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","category-biyoloji","category-molekuler-biyoloji-ve-genetik","tag-kok-hucre","tag-kromatin","tag-rejenerasyon","tag-somatik-hucre"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t