Ara\u015ft\u0131rmac\u0131lar, vir\u00fcslere kar\u015f\u0131 a\u015f\u0131 \u00fcretmeye y\u00f6nelik \u00f6nemli bir ad\u0131m olarak HIV vir\u00fcs\u00fcn\u00fcn ba\u011f\u0131\u015f\u0131kl\u0131k sistemimizi yenmesini sa\u011flayan \u201cs\u00fcrekli de\u011fi\u015fen proteinini\u201d ilk kez y\u00fcksek \u00e7\u00f6z\u00fcn\u00fcrl\u00fckte incelemeyi ba\u015fard\u0131. HIV vir\u00fcs\u00fc, h\u00fccrelerimizi enfekte etmek i\u00e7in kulland\u0131\u011f\u0131 proteinin s\u00fcrekli de\u011fi\u015fmesi sebebiyle, ba\u011f\u0131\u015f\u0131kl\u0131k sistemimizi yenme ve potansiyel a\u015f\u0131lar\u0131 engelleme konusunda \u00e7ok iyidir. Biliminsanlar\u0131 \u00f6rt\u00fcy\u00fc kald\u0131r\u0131p, \u201cy\u00fczey u\u00e7 proteinini\u201d a\u00e7\u0131k bir \u015fekilde g\u00f6rmenin ilk kez bir yolunu buldu.<\/p>\n
ABD Ulusal Sa\u011fl\u0131k Enstit\u00fcs\u00fc, Weill Cornell\u00a0Medikal \u00dcniversitesi ve Yale \u00dcniversitesi\u2019nden ara\u015ft\u0131rmac\u0131lar taraf\u0131ndan yap\u0131lan led (\u0131\u015f\u0131k yayan diyotlar) \u00e7al\u0131\u015fmas\u0131, hareketin y\u00fcksek \u00e7\u00f6z\u00fcn\u00fcrl\u00fckl\u00fc g\u00f6r\u00fcnt\u00fcs\u00fcn\u00fc ve HIV vir\u00fcs\u00fcn\u00fcn h\u00fccrelere ba\u011flanmak i\u00e7in kulland\u0131\u011f\u0131 bu u\u00e7 proteinlerin tam yap\u0131s\u0131n\u0131 g\u00f6sterdi. Sonu\u00e7lar Science<\/em> ve Nature<\/em>\u2019da ayn\u0131 anda yay\u0131mland\u0131.<\/p>\n Yale \u00dcniversitesi\u2019den Science<\/em> gazetesinin k\u0131demli yazar\u0131 bir bas\u0131n a\u00e7\u0131klamas\u0131nda, \u201cArt\u0131k bu f\u00fczyon mekanizmas\u0131n\u0131n nas\u0131l \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131 g\u00f6rebiliyoruz ve genel anlamda bu f\u00fczyon (birle\u015fme) grip ve Ebola vir\u00fcslerinde de ayn\u0131 y\u00f6ntemle \u00e7al\u0131\u015f\u0131r\u201d \u015feklinde konu\u015ftu.<\/p>\n Ara\u015ft\u0131rma, her bir u\u00e7 proteinin \u00fc\u00e7 dizi gp120 ve gp41 adl\u0131 molek\u00fcllerden olu\u015ftu\u011funu ortaya \u00e7\u0131kartt\u0131. Ve biliminsanlar\u0131 bu u\u00e7 proteinlerin \u015feklinin h\u00fccrelere ba\u011flanmadan \u00f6nce ve ba\u011fland\u0131ktan sonra de\u011fi\u015fti\u011fini tespit etti.<\/p>\n Ara\u015ft\u0131rmac\u0131lara g\u00f6re HIV vir\u00fcs\u00fcn\u00fcn h\u00fccrelere ba\u011flan\u0131p proteini enfekte etmesi i\u00e7in u\u00e7 proteinin \u201ca\u00e7\u0131k durumda\u201d olmas\u0131 gereklidir. Fakat, bu protein kapal\u0131 durumda oldu\u011funda antikorlara kar\u015f\u0131 daha az g\u00f6ze \u00e7arpar. Bu y\u00fczden de u\u00e7 proteinler ba\u011f\u0131\u015f\u0131kl\u0131k sistemi taraf\u0131ndan fark edilmeyi \u00f6nlemek i\u00e7in sadece son a\u015famada a\u00e7\u0131l\u0131r.<\/p>\n \u00c7al\u0131\u015fman\u0131n Yale \u00dcniversitesi T\u0131p Okulu aya\u011f\u0131ndan, HIV uzman\u0131 Dr. Walther Mothes,<\/p>\n \u201cHIV u\u00e7 proteinin bu kapal\u0131 konfig\u00fcrasyonunun (bi\u00e7im) yap\u0131s\u0131 ve h\u0131zl\u0131 a\u00e7\u0131lmalar\u0131n\u0131n tespiti ila\u00e7 ve a\u015f\u0131 i\u00e7in ileriye y\u00f6nelik b\u00fcy\u00fck bir ad\u0131m\u0131n ifadesidir\u201d diyor. Ara\u015ft\u0131rma, kimi AIDS hastalar\u0131nda geli\u015fen bir antikor \u00e7e\u015fidine de a\u00e7\u0131klama getirmi\u015f: \u201cAyn\u0131 zamanda ara\u015ft\u0131rma, \u00e7ok az AIDS hastas\u0131nda ke\u015ffedilen ve hastal\u0131\u011fa kar\u015f\u0131 koruma sa\u011flayan nadir bir antikor \u00e7e\u015fidinin var olmas\u0131n\u0131n sebebini a\u00e7\u0131klad\u0131. Bu antikorlar, u\u00e7 proteini kapal\u0131 durumda tutar ve vir\u00fcs\u00fcn yay\u0131lmas\u0131n\u0131 engeller\u201d diyor Mothes.<\/p>\n \u00c7al\u0131\u015fman\u0131n bas\u0131n a\u00e7\u0131klamas\u0131nda ise \u015f\u00f6yle deniyor: \u201cHepsi birlikte ele al\u0131n\u0131rsa, biliminsanlar\u0131na g\u00f6re bulgular, ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin vir\u00fcs\u00fc etkisiz hale getirebilmesini sa\u011flayan etkili bir a\u015f\u0131n\u0131n u\u00e7 proteinin temel haline ve f\u00fczyon (birle\u015fme) \u00f6ncesi yap\u0131s\u0131na g\u00f6re olmas\u0131 gerekti\u011fini g\u00f6steriyor. Art\u0131k, konfig\u00fcrasyonun atomik yap\u0131s\u0131n\u0131 bilmek ara\u015ft\u0131rmac\u0131lar i\u00e7in a\u015f\u0131n\u0131n bile\u015fenleri gibi par\u00e7alar\u0131n tasarlanmas\u0131nda ve manip\u00fcle edilmesinde bir ara\u00e7t\u0131r.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":" Ara\u015ft\u0131rmac\u0131lar, vir\u00fcslere kar\u015f\u0131 a\u015f\u0131 \u00fcretmeye y\u00f6nelik \u00f6nemli bir ad\u0131m olarak HIV vir\u00fcs\u00fcn\u00fcn ba\u011f\u0131\u015f\u0131kl\u0131k sistemimizi yenmesini sa\u011flayan \u201cs\u00fcrekli de\u011fi\u015fen proteinini\u201d ilk kez y\u00fcksek \u00e7\u00f6z\u00fcn\u00fcrl\u00fckte incelemeyi ba\u015fard\u0131. HIV vir\u00fcs\u00fc, h\u00fccrelerimizi enfekte etmek i\u00e7in kulland\u0131\u011f\u0131 proteinin s\u00fcrekli de\u011fi\u015fmesi sebebiyle, ba\u011f\u0131\u015f\u0131kl\u0131k sistemimizi yenme ve potansiyel a\u015f\u0131lar\u0131 engelleme konusunda \u00e7ok iyidir. Biliminsanlar\u0131 \u00f6rt\u00fcy\u00fc kald\u0131r\u0131p, \u201cy\u00fczey u\u00e7 proteinini\u201d a\u00e7\u0131k bir \u015fekilde […]<\/p>\n","protected":false},"author":858,"featured_media":23885,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[166,19,21,33],"tags":[197,2941,443],"class_list":["post-23884","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-129-sayi","category-bilim-gundemi","category-biyoloji","category-saglik-bilimleri","tag-biyoloji","tag-hiv-virusu","tag-saglik-bilimleri"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t