{"id":24470,"date":"2018-05-07T05:50:54","date_gmt":"2018-05-07T02:50:54","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=24470"},"modified":"2018-05-07T10:34:17","modified_gmt":"2018-05-07T07:34:17","slug":"diyabet-hastalari-kendi-insulinlerini-uretebilecek","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2018\/05\/07\/diyabet-hastalari-kendi-insulinlerini-uretebilecek","title":{"rendered":"Diyabet hastalar\u0131 kendi ins\u00fclinlerini \u00fcretebilecek"},"content":{"rendered":"

Biliminsanlar\u0131, tip 1 diyabete \u00e7are bulmak amac\u0131yla s\u00fcrd\u00fcr\u00fclen ara\u015ft\u0131rmada, ins\u00fclin \u00fcreten k\u00f6k h\u00fccreler geli\u015ftirerek b\u00fcy\u00fck bir ilerleme kaydettiler. Cell<\/em> dergisinde yay\u0131mlanan \u00e7al\u0131\u015fmaya g\u00f6re, Harvard \u00dcniversitesi\u2019ndeki bir grup ara\u015ft\u0131rmac\u0131, pek \u00e7ok h\u00fccre \u00e7e\u015fidine d\u00f6n\u00fc\u015febilme potansiyeline sahip olan \u201ck\u00f6k h\u00fccreler\u201di \u201cbeta h\u00fccreleri\u201dne d\u00f6n\u00fc\u015ft\u00fcrmeyi ba\u015fard\u0131 (Beta h\u00fccreleri, \u00fcrettikleri ins\u00fclin sayesinde kan \u015fekerini d\u00fczenlemeye yard\u0131mc\u0131 olur). Elde edilen bu h\u00fccreler diyabetik farelere yerle\u015ftirildikten sonra, farelerin kan \u015feker d\u00fczeyi birka\u00e7 ay boyunca izlendi.<\/p>\n

Sonu\u00e7lar, s\u00f6z konusu h\u00fccrelerin normal beta h\u00fccreleri gibi i\u015flev g\u00f6rd\u00fc\u011f\u00fcn\u00fc ve diyabetik farelerin aksine, ba\u011f\u0131\u015f\u0131kl\u0131k sistemi taraf\u0131ndan sald\u0131r\u0131ya u\u011framad\u0131klar\u0131n\u0131 g\u00f6sterdi. Sonradan yerle\u015ftirilen bu h\u00fccrelerin kan \u015fekeri d\u00fczeylerine olduk\u00e7a duyarl\u0131 bir bi\u00e7imde yan\u0131t verdikleri ve alt\u0131 ay sonra farelerin kan \u015fekeri d\u00fczeylerinin kontrol alt\u0131nda kald\u0131\u011f\u0131 g\u00f6zlemlendi. Bu geli\u015fme, diyabet hastalar\u0131n\u0131n g\u00fcnl\u00fck ins\u00fclin i\u011fnelerinden kurtulmalar\u0131na yard\u0131mc\u0131 olabilecek \u00f6nemli bir ad\u0131m.<\/p>\n

Ara\u015ft\u0131rman\u0131n y\u00f6neticisi Doug Melton \u015f\u00f6yle s\u00f6yl\u00fcyor: \u201cElbette pek \u00e7ok a\u00e7\u0131dan test edilmedik\u00e7e b\u00f6yle bir \u00e7\u00f6z\u00fcm\u00fcn kesin olarak i\u015fe yarayaca\u011f\u0131na emin olamay\u0131z. Ama \u00fc\u00e7 ayr\u0131 deneyde farelere bu h\u00fccreleri yerle\u015ftirdik ve verdi\u011fimiz glukoza ba\u015far\u0131l\u0131 yan\u0131t verdiklerini g\u00f6zlemledik, bu ger\u00e7ekten heyecan vericiydi.\u201d<\/p>\n

Tip 1 diyabet, D\u00fcnya\u2019da 34 milyonun \u00fczerinde insan\u0131 etkileyen ve ya\u015fam boyu devam eden kronik bir otoimm\u00fcn hastal\u0131kt\u0131r. Tip 1 diyabetli hastalarda, v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k sistemi pankreasta bulunan ve ins\u00fclin sentezleyen beta h\u00fccrelerine sald\u0131rarak onlara zarar verir.<\/p>\n

Tip 1 diyabet hastalar\u0131 kan \u015fekerlerini kontrol alt\u0131nda tutabilmek i\u00e7in g\u00fcnl\u00fck ins\u00fclin i\u011fnelerine ihtiya\u00e7 duyarlar. Fakat g\u00fcnl\u00fck enjeksiyon, kandaki \u015feker d\u00fczeyine g\u00f6re yan\u0131t veren normal beta h\u00fccrelerinin yerini tutamaz ve bu y\u00fczden hastalar diyabete ba\u011fl\u0131 sinir hasar\u0131, g\u00f6rme kayb\u0131 ve uzuv kayb\u0131 gibi problemler ya\u015fayabilir. G\u00fcn\u00fcm\u00fczde bu hastal\u0131\u011f\u0131n bilinen tek kesin tedavisi beta h\u00fccresi naklidir, ki bu da ancak \u00f6len bir ki\u015fiden al\u0131nmas\u0131 yoluyla m\u00fcmk\u00fcnd\u00fcr. Fakat bu i\u015flem de, do\u011fas\u0131 gere\u011fi \u00e7ok az say\u0131da insan i\u00e7in bir se\u00e7enek olabilmekte ve nakil yap\u0131lan hastalar \u00f6m\u00fcr boyu ba\u011f\u0131\u015f\u0131kl\u0131k sistemini bask\u0131lay\u0131c\u0131 ila\u00e7lar kullanmaktad\u0131r.<\/p>\n

Melton, her iki \u00e7ocu\u011funun \u00e7ok gen\u00e7 ya\u015fta tip 1 diyabete yakalanmas\u0131ndan sonra, bu hastal\u0131\u011fa \u015fifa bulmaya karar verdi\u011fini s\u00f6yl\u00fcyor. Ara\u015ft\u0131rmada \u00fcretilen beta h\u00fccreleri \u015fu an insan d\u0131\u015f\u0131 primatlar da dahil \u00f6teki hayvan modellerinde de test ediliyor. Hastal\u0131\u011fa \u00e7are bulmak i\u00e7in sonraki ad\u0131m, hastalara implante edilecek 150 milyon civar\u0131ndaki beta h\u00fccresinin ba\u011f\u0131\u015f\u0131kl\u0131k sistemi sald\u0131r\u0131s\u0131ndan nas\u0131l korunabilece\u011fi. Melton, h\u00fccreleri korumak amac\u0131yla v\u00fccuda yerle\u015ftirilebilecek bir cihaz geli\u015ftimek i\u00e7in MIT\u2019den Prof. Daniel Anderson ile birlikte \u00e7al\u0131\u015f\u0131yor. Anderson, Melton\u2019un yapt\u0131\u011f\u0131 ara\u015ft\u0131rmayla ilgili \u015funlar\u0131 s\u00f6yl\u00fcyor: \u201cDiyabet i\u00e7in ola\u011fan\u00fcst\u00fc \u00f6nemli bir geli\u015fme. Hi\u00e7 \u015f\u00fcphe yok ki, k\u00f6k h\u00fccrelerinden kontroll\u00fc farkl\u0131la\u015fma yoluyla glukoza duyarl\u0131 insan beta h\u00fccrelerinin elde edilmesi, buna benzer yeni terapilerin de geli\u015ftirilmesini h\u0131zland\u0131racakt\u0131r. \u00d6zellikle bu \u00e7al\u0131\u015fma, h\u00fccre terapisi bekleyen diyabet hastalar\u0131na s\u0131n\u0131rs\u0131z miktarda doku sunulmas\u0131na kap\u0131 aralayacak bir geli\u015fmedir.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

Biliminsanlar\u0131, tip 1 diyabete \u00e7are bulmak amac\u0131yla s\u00fcrd\u00fcr\u00fclen ara\u015ft\u0131rmada, ins\u00fclin \u00fcreten k\u00f6k h\u00fccreler geli\u015ftirerek b\u00fcy\u00fck bir ilerleme kaydettiler. Cell dergisinde yay\u0131mlanan \u00e7al\u0131\u015fmaya g\u00f6re, Harvard \u00dcniversitesi\u2019ndeki bir grup ara\u015ft\u0131rmac\u0131, pek \u00e7ok h\u00fccre \u00e7e\u015fidine d\u00f6n\u00fc\u015febilme potansiyeline sahip olan \u201ck\u00f6k h\u00fccreler\u201di \u201cbeta h\u00fccreleri\u201dne d\u00f6n\u00fc\u015ft\u00fcrmeyi ba\u015fard\u0131 (Beta h\u00fccreleri, \u00fcrettikleri ins\u00fclin sayesinde kan \u015fekerini d\u00fczenlemeye yard\u0131mc\u0131 olur). Elde edilen bu […]<\/p>\n","protected":false},"author":847,"featured_media":24472,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[166,19,21,33],"tags":[2761,1992,2994,425],"class_list":["post-24470","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-129-sayi","category-bilim-gundemi","category-biyoloji","category-saglik-bilimleri","tag-diyabet","tag-hucreler","tag-insulin","tag-saglik"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t