{"id":2491,"date":"2015-04-07T13:32:01","date_gmt":"2015-04-07T10:32:01","guid":{"rendered":"http:\/\/bilimvegelecek.com.tr\/?p=2491"},"modified":"2015-04-07T13:32:01","modified_gmt":"2015-04-07T10:32:01","slug":"agir-sizofrenlerin-beyin-ag-yapilari-farkli","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2015\/04\/07\/agir-sizofrenlerin-beyin-ag-yapilari-farkli","title":{"rendered":"A\u011f\u0131r \u015fizofrenlerin beyin a\u011f yap\u0131lar\u0131 farkl\u0131"},"content":{"rendered":"

G\u00f6rsel:<\/strong> Beynin MR (Manyetik Rezonans) g\u00f6r\u00fcnt\u00fcs\u00fc.<\/p>\n

Ba\u011f\u0131ml\u0131l\u0131k ve Ak\u0131l Sa\u011fl\u0131\u011f\u0131 Merkezi\u2019nin yeni ara\u015ft\u0131rmas\u0131na g\u00f6re; a\u011f\u0131r \u015fizofreni vakas\u0131 olan ki\u015filer ile di\u011fer sa\u011fl\u0131kl\u0131, \u015fizofren ya da bipolar bozuklu\u011fu olan ki\u015filerin beyin a\u011flar\u0131 kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, aralar\u0131nda \u00f6nemli farkl\u0131l\u0131klar\u0131n oldu\u011fu g\u00f6sterildi.
\nBu \u00e7al\u0131\u015fma, beyin a\u011flar\u0131n\u0131 haritaland\u0131rmada yeni bir y\u00f6ntem kullanan, Ba\u011f\u0131ml\u0131l\u0131k ve Ak\u0131l Sa\u011fl\u0131\u011f\u0131 Merkezi\u2019nin Campbell Aile Ak\u0131l Sa\u011fl\u0131\u011f\u0131 Ara\u015ft\u0131rma Enstit\u00fcs\u00fc\u2019ndeki ara\u015ft\u0131rmac\u0131lar taraf\u0131ndan y\u00fcr\u00fct\u00fcld\u00fc ve JAMA Psychiatry dergisinde yay\u0131mland\u0131.
\nRapordan sorumlu yazar ve Ba\u011f\u0131ml\u0131l\u0131k ve Ak\u0131l Sa\u011fl\u0131\u011f\u0131 Merkezi\u2019nde y\u00f6netici olan Dr. Aristotle Voinescos, \u201cBulgular birinci \u00f6ncelik olarak \u015fizofren ki\u015filerin iyile\u015fmesine yard\u0131mc\u0131 olacak, 20 y\u0131l kadar \u00f6ncesine dayanan te\u015fhislerde bile. Sosyal izolasyon, i\u015f ve ili\u015fki eksikli\u011fi ve kronik yetersizlikler bu ki\u015filerde \u00e7ok yayg\u0131n\u201d diyor.
\n\u015eizofreni, her 100 ki\u015fiden birini etkileyen, sanr\u0131 ve hal\u00fcsinasyon g\u00f6rme semptomlar\u0131yla bilinen ve antipsikotik ila\u00e7larla tedavi edilebilen bir hastal\u0131kt\u0131r. Fakat motivasyon eksikli\u011fi ve sosyal y\u0131k\u0131m da, hastal\u0131\u011f\u0131n di\u011fer karakteristik semptomlar\u0131d\u0131r. Bunlar negatif belirti olarak da bilinir.
\n\u201cBu negatif belirtilere, yakla\u015f\u0131k her be\u015f \u015fizofrenden birinde rastland\u0131\u011f\u0131n\u0131\u201d s\u00f6yl\u00fcyor Ba\u011f\u0131ml\u0131l\u0131k ve Ak\u0131l Sa\u011fl\u0131\u011f\u0131 Merkezi\u2019nde doktora sonras\u0131 ara\u015ft\u0131rmac\u0131 olarak \u00e7al\u0131\u015fan, makalenin ba\u015fyazar\u0131 olan Dr. Anne Wheeler. Bu noktada, olumsuz etkiler i\u00e7in bir \u00e7are bulunmuyor, bundan dolay\u0131 ara\u015ft\u0131rmac\u0131lar bu psikotik ki\u015fileri normal hayatlar\u0131nda g\u00f6zlemlediklerinde, bu onlar\u0131n \u00fcst\u00fcnde \u00e7ok b\u00fcy\u00fck bir etki yaratm\u0131\u015f,
\nBiyolojik, beyin tabanl\u0131 g\u00f6stergeler, \u015fizofren ki\u015filerde hastal\u0131\u011f\u0131n te\u015fhisinde yard\u0131mc\u0131 olabilecek. \u201cYoksa bunun klinik \u00e7al\u0131\u015fmalarla belirlenmesi y\u0131llar alabilir\u201d diyor Dr. Voineskos.
\n\u00c7al\u0131\u015fma, manyetik rezonans (MR) beyin g\u00f6r\u00fcnt\u00fcleme tekni\u011fi kullan\u0131larak, 128 \u015fizofren ve 130 sa\u011fl\u0131kl\u0131 ki\u015fide iki farkl\u0131 yerde ve 39 bipolar bozuklu\u011fu olan ve 43 sa\u011fl\u0131kl\u0131 ki\u015fide \u00fc\u00e7 farkl\u0131 yerde ger\u00e7ekle\u015ftirildi. Bipolar bozuklu\u011fu olan hastalarda ayn\u0131 zamanda psikotik belirtiler de g\u00f6r\u00fcld\u00fc, fakat bunlar olumsuz belirtiler de\u011fildi, bundan dolay\u0131 hastalar kontrol grubu olarak g\u00f6rev yapm\u0131\u015f oldular. Bu \u00e7al\u0131\u015fman\u0131n y\u00fcr\u00fct\u00fcld\u00fc\u011f\u00fc \u00fc\u00e7 ayr\u0131 yer, Ba\u011f\u0131ml\u0131l\u0131k ve Ak\u0131l Sa\u011fl\u0131\u011f\u0131 Merkezi (Kanada), Zucker Hillside Hastanesi (Glen Oaks, New York) ve Ak\u0131l Sa\u011fl\u0131\u011f\u0131 Merkez Enstit\u00fcs\u00fc (Mannheim, Almanya).
\nAra\u015ft\u0131rmac\u0131lar beyindeki ba\u011flant\u0131 seviyeleri ya da genel a\u011f yo\u011funlu\u011fu analiz y\u00f6ntemini kulland\u0131lar. Dr. Voineskos \u201cA\u011f\u0131r \u015fizofren ve di\u011fer gruplar\u0131, daha iyi durumda olan \u015fizofreniler de dahil olmak \u00fczere kar\u015f\u0131la\u015ft\u0131rarak, beyin b\u00f6lgeleri aras\u0131ndaki ba\u011flant\u0131 miktar\u0131n\u0131n de\u011fi\u015fimini bulduk\u201d diyor. \u201cBu \u015fizofreninin sadece bir bozukluktan kaynaklanmad\u0131\u011f\u0131n\u0131n g\u00fc\u00e7l\u00fc bir kan\u0131t\u0131 oldu.\u201d
\nBu \u00e7al\u0131\u015fma ayn\u0131 zamanda, ayn\u0131 tak\u0131m\u0131n daha \u00f6nce yapt\u0131\u011f\u0131, daha a\u011f\u0131r \u015fizofreni vakalar\u0131nda, beyindeki beyaz madde dokular\u0131n\u0131n ba\u011flant\u0131lar\u0131n\u0131n de\u011fi\u015fimini g\u00f6steren \u00e7al\u0131\u015fmay\u0131 da onaylam\u0131\u015f oldu.
\nMakalede yaz\u0131ld\u0131\u011f\u0131na g\u00f6re, bu bozulmu\u015f a\u011flar, hastan\u0131n sosyal i\u015flev deneyimleri ve negatif semptomlarla ilintili beyin s\u00fcre\u00e7lerinde \u00f6nem ta\u015f\u0131yor. ABD Ulusal Ak\u0131l Sa\u011fl\u0131\u011f\u0131 Enstit\u00fcs\u00fc, bu bulgulara dayan\u0131larak yap\u0131lan, \u00e7ok say\u0131da \u015fizofren \u00fczerinde y\u00fcr\u00fct\u00fclen \u00e7ok-merkezli bir \u00e7al\u0131\u015fmay\u0131 y\u00fcr\u00fct\u00fcyor ve finanse ediyor; bu \u00e7al\u0131\u015fmada, beyin d\u00f6ng\u00fcs\u00fcndeki b\u00fcy\u00fck \u00e7apl\u0131 bozuklu\u011fun, sosyal i\u015flevleri de bozmas\u0131 konu ediliyor.
\nBu \u00e7al\u0131\u015fmalar vas\u0131tas\u0131yla, \u00f6zel beyin d\u00f6ng\u00fcleri belirlenip, negatif semptomlar ve sosyal i\u015flevsizlik i\u00e7in yeni terapi yakla\u015f\u0131mlar\u0131 geli\u015ftirilebilir. Bu kapsamda, Ba\u011f\u0131ml\u0131l\u0131k ve Ak\u0131l Sa\u011fl\u0131\u011f\u0131 Merkezi\u2019nde g\u00f6rsel teknoloji ve beyin sim\u00fclasyonlar\u0131 kullan\u0131larak benzer \u00e7al\u0131\u015fmalar y\u00fcr\u00fct\u00fcl\u00fcyor.<\/p>\n

\u00c7eviren: R\u0131za Acar
\n\u0130T\u00dc Molek\u00fcler Biyoloji ve Genetik Blm<\/strong><\/em><\/p>\n

Kaynak:<\/strong> http:\/\/www.sciencedaily.com\/releases\/2015\/03\/150318130334.htm <\/p>\n","protected":false},"excerpt":{"rendered":"

G\u00f6rsel: Beynin MR (Manyetik Rezonans) g\u00f6r\u00fcnt\u00fcs\u00fc. Ba\u011f\u0131ml\u0131l\u0131k ve Ak\u0131l Sa\u011fl\u0131\u011f\u0131 Merkezi\u2019nin yeni ara\u015ft\u0131rmas\u0131na g\u00f6re; a\u011f\u0131r \u015fizofreni vakas\u0131 olan ki\u015filer ile di\u011fer sa\u011fl\u0131kl\u0131, \u015fizofren ya da bipolar bozuklu\u011fu olan ki\u015filerin beyin a\u011flar\u0131 kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, aralar\u0131nda \u00f6nemli farkl\u0131l\u0131klar\u0131n oldu\u011fu g\u00f6sterildi. Bu \u00e7al\u0131\u015fma, beyin a\u011flar\u0131n\u0131 haritaland\u0131rmada yeni bir y\u00f6ntem kullanan, Ba\u011f\u0131ml\u0131l\u0131k ve Ak\u0131l Sa\u011fl\u0131\u011f\u0131 Merkezi\u2019nin Campbell Aile Ak\u0131l Sa\u011fl\u0131\u011f\u0131 […]<\/p>\n","protected":false},"author":1,"featured_media":2492,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19,35,33],"tags":[],"class_list":["post-2491","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","category-noroloji","category-saglik-bilimleri"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t