Ara\u015ft\u0131rmac\u0131lar, ya\u015fl\u0131 farelerdeki beyin ve kas hasarlar\u0131n\u0131 iyile\u015ftirmekte kullan\u0131labilecek bir bile\u015feni gen\u00e7 fare kan\u0131nda buldu.<\/p>\n
Gen\u00e7 farelerden al\u0131nan kan\u0131n, ya\u015fl\u0131 farelerdeki eskimi\u015f k\u00f6k h\u00fccrelerini canland\u0131rabildi\u011fi biliminsanlar\u0131 taraf\u0131ndan birka\u00e7 y\u0131ld\u0131r biliniyordu. Ge\u00e7en seneyse, b\u00fcy\u00fcme t\u00fcrevleme etkeni 11 (growth differentiation factor 11, GDF11) olarak bilinen ve ya\u015fl\u0131 farelere k\u0131yasla gen\u00e7 farelerin kan\u0131nda \u00e7ok daha bol bulunan proteinin kardiyak hipertrofiyi, yani kalp h\u00fccrelerinin kalp sorunlar\u0131na neden olabilecek \u015fekilde ya\u015fa ba\u011fl\u0131 olarak \u015fi\u015fmesi ve kal\u0131nla\u015fmas\u0131n\u0131 geri \u00e7evirdi\u011fi g\u00f6sterilmi\u015fti. \u015eimdi de iki farkl\u0131 ara\u015ft\u0131rma grubu GDF11\u2019in daha genel olarak kas yenilenmesi ve ya\u015fla ilgili beyin h\u00fccresi hasarlar\u0131n\u0131n iyile\u015ftirilmesinde de yard\u0131mc\u0131 olabilece\u011fini ke\u015ffetti. Harvard T\u0131p Fak\u00fcltesi\u2019nde \u00e7al\u0131\u015fan ve ara\u015ft\u0131rmayla ilgisi olmayan Rudolph Tanzi, New York Times<\/em>\u2019a \u015funlar\u0131 s\u00f6yledi: \u201cA\u015f\u0131r\u0131 heyecanl\u0131y\u0131m, bu bulgular oyunun kurallar\u0131n\u0131 de\u011fi\u015ftirebilir.\u201d<\/p>\n Harvard \u00dcniversitesi k\u00f6k h\u00fccre ara\u015ft\u0131rmac\u0131s\u0131 Amy Wagers ve \u00e7al\u0131\u015fma arkada\u015flar\u0131, Science<\/em>\u2019\u0131n 5 May\u0131s tarihli say\u0131s\u0131nda yay\u0131mlad\u0131klar\u0131 bir \u00e7ift ara\u015ft\u0131rmayla, GDF11\u2019in ya\u015flanm\u0131\u015f farelerdeki eski kas dokular\u0131n\u0131 iyile\u015ftirebilece\u011fini ve ya\u015flanmakta olan farelerdeki beyin damar da\u011f\u0131l\u0131m\u0131n\u0131 geli\u015ftirip yeni h\u00fccre do\u011fumunu kuvvetlendirebilece\u011fini bildirdiler. B\u00f6yle bir tedavinin insanlar \u00fczerinde uygulanabilmesi ve klinik bir ger\u00e7e\u011fe d\u00f6n\u00fc\u015fmesinden \u00f6nce daha \u00e7ok ara\u015ft\u0131rma gerekiyor olsa da, bu proteinin insanlardaki versiyonun, benzer \u015fekilde ya\u015flanma-kar\u015f\u0131t\u0131 etkileri olmas\u0131 umuluyor. Wagers, New Scientist<\/em>\u2019e verdi\u011fi deme\u00e7te \u201cKlinik uygulamalardan \u00f6nce, GDF11\u2019in neden ya\u015flanmayla beraber kaybedildi\u011fi ve ya\u015fl\u0131 farelerde kar\u015f\u0131t-denetiminin geli\u015fip geli\u015fmedi\u011fi gibi konular da dahil olmak \u00fczere yap\u0131lmas\u0131 gereken baz\u0131 \u00e7ok \u00f6nemli ara\u015ft\u0131rmalar oldu\u011funa inan\u0131yorum\u201d dedi. \u201cSan\u0131yorum bu sorular\u0131 \u00f6n\u00fcm\u00fczdeki \u00fc\u00e7 be\u015f sene i\u00e7erisinde cevaplay\u0131p, bu zaman \u00e7er\u00e7evesi i\u00e7erisinde klinik deneylere haz\u0131r olabiliriz.\u201d<\/p>\n Stanford \u00dcniversitesi T\u0131p Fak\u00fcltesi ara\u015ft\u0131rmac\u0131lar\u0131, 4 May\u0131s tarihli Nature Medicine<\/em> i\u00e7erisinde yay\u0131mlad\u0131klar\u0131 \u00fc\u00e7\u00fcnc\u00fc bir makalede, gen\u00e7 farelerden al\u0131nan kan\u0131n ya\u015fl\u0131 farelerdeki sinaptik plastisiteyi iyile\u015ftirebilece\u011fini ve alg\u0131sal i\u015flevleri geli\u015ftirebilece\u011fini g\u00f6sterdiler. \u00dc\u00e7 ayl\u0131k farelerden ald\u0131klar\u0131 plazma \u00f6rneklerini 18 ayl\u0131k farelere uygulayan ve \u00fc\u00e7 hafta sonra ya\u015fl\u0131 farelerdeki beyin h\u00fccrelerinin, plasebo verilen farelerden y\u00fczde 20 daha \u00e7ok dallanmaya sahip oldu\u011funu g\u00f6zlemleyen grubun lideri, Stanford ara\u015ft\u0131rmac\u0131s\u0131 Tony Wyss-Coray BBC\u2019ye \u015funlar\u0131 s\u00f6yledi: \u201cGen\u00e7 farelerin kan\u0131nda, ya\u015fl\u0131 farelerin beynini \u015farj edip bir gen\u00e7 farenin beyniymi\u015f gibi \u00e7al\u0131\u015fmas\u0131na sebep olacak etkenler var. Bu etkenlerin ne olabilece\u011fi ve hangi dokular taraf\u0131ndan \u00fcretildi\u011fi \u00fczerine etrafl\u0131 ara\u015ft\u0131rmalar yap\u0131yoruz.\u201d Ayr\u0131ca tak\u0131m\u0131n\u0131n, bu y\u0131l\u0131n sonu i\u00e7in, Alzheimer hastalar\u0131n\u0131n gen\u00e7 ve sa\u011fl\u0131kl\u0131 g\u00f6n\u00fcll\u00fclerden kan plazmas\u0131 alaca\u011f\u0131 insan deneylerini planlad\u0131\u011f\u0131n\u0131 ekledi.<\/p>\n","protected":false},"excerpt":{"rendered":" Ara\u015ft\u0131rmac\u0131lar, ya\u015fl\u0131 farelerdeki beyin ve kas hasarlar\u0131n\u0131 iyile\u015ftirmekte kullan\u0131labilecek bir bile\u015feni gen\u00e7 fare kan\u0131nda buldu. Gen\u00e7 farelerden al\u0131nan kan\u0131n, ya\u015fl\u0131 farelerdeki eskimi\u015f k\u00f6k h\u00fccrelerini canland\u0131rabildi\u011fi biliminsanlar\u0131 taraf\u0131ndan birka\u00e7 y\u0131ld\u0131r biliniyordu. Ge\u00e7en seneyse, b\u00fcy\u00fcme t\u00fcrevleme etkeni 11 (growth differentiation factor 11, GDF11) olarak bilinen ve ya\u015fl\u0131 farelere k\u0131yasla gen\u00e7 farelerin kan\u0131nda \u00e7ok daha bol bulunan proteinin […]<\/p>\n","protected":false},"author":614,"featured_media":25049,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[161,19],"tags":[982,3179,2522,424,3180],"class_list":["post-25040","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-124-sayi","category-bilim-gundemi","tag-alzheimer","tag-buyume","tag-kan","tag-kok-hucre","tag-turevleme"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/25040","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/614"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=25040"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/25040\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media\/25049"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=25040"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=25040"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=25040"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}