{"id":25549,"date":"2014-05-01T15:30:06","date_gmt":"2014-05-01T12:30:06","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=25549"},"modified":"2018-05-15T15:37:59","modified_gmt":"2018-05-15T12:37:59","slug":"ebedi-genclik-mumkun","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2014\/05\/01\/ebedi-genclik-mumkun","title":{"rendered":"Ebedi gen\u00e7lik m\u00fcmk\u00fcn!"},"content":{"rendered":"

The Economist<\/em>\u2019te yay\u0131mlanan makaleye g\u00f6re, bir ara\u015ft\u0131rma ekibi, farelerde, ba\u011f\u0131\u015f\u0131kl\u0131k sistemi organ\u0131 olan timusu geli\u015ftirebildi. B\u00f6ylelikle hem olas\u0131 kanserlerle sava\u015fmak hem de gen\u00e7li\u011fin \u00e7e\u015fmesinden i\u00e7ebilmek m\u00fcmk\u00fcn olabilecek.<\/p>\n

\u00c7al\u0131\u015fmalar\u0131n\u0131 Development<\/em> dergisinde yay\u0131mlayan \u0130ngiltere Edinburgh \u00dcniversitesi\u2019nden Clare Blackburn ve ekibi, ya\u015f ilerledik\u00e7e etkinli\u011fini giderek kaybeden ve ba\u011f\u0131\u015f\u0131kl\u0131k sistemine deste\u011fi neredeyse yok olan timus bezini, k\u00f6k h\u00fccreler eklemek yerine, FOXN1 proteini \u00fcretimini uyararak b\u00fcy\u00fctmeyi ba\u015fard\u0131lar. Bu protein, gen aktivasyonunu sa\u011flayan molek\u00fcler bir d\u00fc\u011fme gibiydi ve timus i\u00e7in de hi\u00e7 ku\u015fkusuz ya\u015fam iksiriydi.<\/p>\n

Timus bezi ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin ana elemanlar\u0131 olan T h\u00fccrelerinin olgunla\u015ft\u0131\u011f\u0131 organd\u0131r. T h\u00fccreleri vir\u00fcsle enfekte olmu\u015f v\u00fccut h\u00fccrelerini yok etmek gibi esasl\u0131 bir g\u00f6rev yaparlar. Organizma ya\u015fland\u0131k\u00e7a timus bezi k\u00fc\u00e7\u00fcl\u00fcr ve i\u015flevini kaybeder. Sonu\u00e7 olarak yeni T h\u00fccrelerinin yap\u0131m\u0131 da azalm\u0131\u015f olur. Bu da ya\u015fl\u0131 bireylerin gen\u00e7lere g\u00f6re hastal\u0131klara kar\u015f\u0131 neden daha diren\u00e7siz oldu\u011funu a\u00e7\u0131klar.<\/p>\n

Dr. Blackburn daha \u00f6nceki deneylerinden FOXN1 proteininin timusun embriyonik geli\u015fimi i\u00e7in \u00f6nemli oldu\u011funu biliyordu. Bu bilgiyle, ya\u015fl\u0131 organizmalarda timusun yeniden aktive edilmesinin m\u00fcmk\u00fcn olup olmad\u0131\u011f\u0131n\u0131 ara\u015ft\u0131rmak istedi. Bu sebeple fare deneklerine, meme kanserindeki kullan\u0131m\u0131yla bilinen tamoksifen vererek, FOXN1 protein \u00fcretimini uyard\u0131lar. Bu fareler 1-1,5 ya\u015f\u0131ndalard\u0131 ve orta ya da ya\u015fl\u0131 insan ya\u015f\u0131na denk geliyorlard\u0131. FOXN1 \u00fcretimiyle gen\u00e7lerin timusunda 2,7; daha ya\u015fl\u0131larda 2,6 kez b\u00fcy\u00fcme g\u00f6zlemlediler. Ayr\u0131ca farelerin i\u00e7 organlar\u0131n\u0131n yap\u0131sal olarak gen\u00e7le\u015fmeye ba\u015flad\u0131\u011f\u0131n\u0131 ve T h\u00fccre yo\u011funlu\u011funun artt\u0131\u011f\u0131n\u0131 belirlediler.<\/p>\n

Elbette bu \u00e7al\u0131\u015fmalar medikal tedaviye model olmayacak. FOXN1 do\u011fal olarak tamoksifene duyarl\u0131 de\u011fil. Ancak \u015fimdilik sadece k\u00f6k h\u00fccrelerle sa\u011fland\u0131\u011f\u0131 g\u00f6zlenebilen tim\u00fcs b\u00fcy\u00fcmesinde ve yenilenmesinde, ba\u015fka yollar\u0131n da olabilece\u011fini g\u00f6steren \u00e7ok \u00f6nemli bir pencere a\u00e7acakt\u0131r.<\/p>\n

Kaynaklar<\/strong><\/p>\n

1) http:\/\/www.economist.com\/news\/science-and-technology\/21600356-first-time-mammalian-organ-has-been-persuaded-renew-itself-engage-0#sthash.V5xmR3JT.dpbs<\/p>\n

2) http:\/\/www.popsci.com\/article\/science\/first-successful-regeneration-organ-mammal?src=SOC&dom=fb<\/p>\n","protected":false},"excerpt":{"rendered":"

The Economist\u2019te yay\u0131mlanan makaleye g\u00f6re, bir ara\u015ft\u0131rma ekibi, farelerde, ba\u011f\u0131\u015f\u0131kl\u0131k sistemi organ\u0131 olan timusu geli\u015ftirebildi. B\u00f6ylelikle hem olas\u0131 kanserlerle sava\u015fmak hem de gen\u00e7li\u011fin \u00e7e\u015fmesinden i\u00e7ebilmek m\u00fcmk\u00fcn olabilecek. \u00c7al\u0131\u015fmalar\u0131n\u0131 Development dergisinde yay\u0131mlayan \u0130ngiltere Edinburgh \u00dcniversitesi\u2019nden Clare Blackburn ve ekibi, ya\u015f ilerledik\u00e7e etkinli\u011fini giderek kaybeden ve ba\u011f\u0131\u015f\u0131kl\u0131k sistemine deste\u011fi neredeyse yok olan timus bezini, k\u00f6k h\u00fccreler eklemek […]<\/p>\n","protected":false},"author":42,"featured_media":25550,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[160,19,38],"tags":[1194,3274,1766],"class_list":["post-25549","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-123-sayi","category-bilim-gundemi","category-dergi-sayilari","tag-bagisiklik","tag-ebedli-genclik","tag-genclik"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t