Warwick ve Manchester \u00dcniversitesi\u2019nden matematik\u00e7i ve biyologlardan olu\u015fan bir grubun yapt\u0131\u011f\u0131 ara\u015ft\u0131rmaya g\u00f6re, v\u00fccudumuzun s\u0131cakl\u0131\u011f\u0131 ne kadar y\u00fcksek olursa, v\u00fccudumuzun t\u00fcm\u00f6rlere, yaralara ve enfeksiyonlara kar\u015f\u0131 sava\u015fmakla g\u00f6revli olan savunma sistemi o kadar h\u0131zlan\u0131yor.<\/p>\n
Ara\u015ft\u0131rmac\u0131lar, v\u00fccut s\u0131cakl\u0131\u011f\u0131ndaki ufak tefek y\u00fckselmelerin (ate\u015flenme esnas\u0131nda oldu\u011fu gibi) enfeksiyonlara verilen tepkiyi kontrol eden h\u00fccresel \u201csaat\u201d h\u0131z\u0131n\u0131 artt\u0131rd\u0131\u011f\u0131n\u0131 ve bu yeni ke\u015fif sayesinde bu s\u00fcre\u00e7te yer alan \u00f6nemli bir proteini hedef alan, daha etkili ve h\u0131zl\u0131 \u00e7al\u0131\u015fan ila\u00e7lar\u0131n \u00f6n\u00fcn\u00fcn a\u00e7\u0131labilece\u011fini g\u00f6sterdi. Biyologlar, inflamatuvar sinyallerin NF-kB proteinlerinin, genleri a\u00e7\u0131p kapad\u0131klar\u0131 h\u00fccre \u00e7ekirde\u011finin i\u00e7inde ve d\u0131\u015f\u0131nda, ileri-geri hareket ettiren bir kronometre ba\u015flatmak i\u00e7in \u2018N\u00fckleer Fakt\u00f6r kappa B\u2019 (NF-kB) proteinlerini aktive ettiklerini buldular. Bu bulu\u015f, h\u00fccrelerin bir t\u00fcm\u00f6re, yara veya enfeksiyona yan\u0131t vermesine olanak sa\u011fl\u0131yor. NF-kB\u2019nin kontrols\u00fcz olmas\u0131, Crohn hastal\u0131\u011f\u0131, sedef hastal\u0131\u011f\u0131 ve romatoid artrit gibi iltihapl\u0131 hastal\u0131klar\u0131n g\u00f6r\u00fclmesine neden oluyor.<\/p>\n
Yeni y\u00f6ntemler<\/strong> \u00c7al\u0131\u015fma ekibinden Prof. Dr. David Rand, yirmi d\u00f6rt saatlik normal bir g\u00fcnde v\u00fccut saatinin, v\u00fccut s\u0131cakl\u0131\u011f\u0131ndaki k\u00fc\u00e7\u00fck (1,5 derece) de\u011fi\u015fiklikleri kontrol etti\u011fini s\u00f6yledi. Rand, \u201cUyku s\u0131ras\u0131nda v\u00fccut \u0131s\u0131s\u0131n\u0131n d\u00fc\u015f\u00fck olmas\u0131, vardiyal\u0131 \u00e7al\u0131\u015fma, jet lag veya uyku bozukluklar\u0131n\u0131n nas\u0131l iltihapl\u0131 ve ate\u015fli hastal\u0131klar\u0131 art\u0131rd\u0131\u011f\u0131na dair \u00e7ok \u00e7arp\u0131c\u0131 bir a\u00e7\u0131klama sunabilir\u201d diyor.<\/p>\n \u00c7al\u0131\u015fman\u0131n gelece\u011fi<\/strong> Bir\u00e7ok NF-kB kontroll\u00fc genin aktiviteleri s\u0131cakl\u0131ktan etkilenmezken, \u00f6nemli bir gen grubu farkl\u0131 s\u0131cakl\u0131klarda de\u011fi\u015ftirilmi\u015f profiller g\u00f6sterdi. Bu s\u0131cakl\u0131\u011fa duyarl\u0131 genler, h\u00fccre tepkilerini de\u011fi\u015ftirebilen \u00f6nemli inflamatuvar d\u00fczenleyiciler ve h\u00fccre ileti\u015fim denetleyicileri i\u00e7eriyor.<\/p>\n Manchester \u00dcniversitesi\u2019nden biyolog Profes\u00f6r Mike White, \u00e7al\u0131\u015fman\u0131n hem \u00e7evrenin hem de v\u00fccut s\u0131cakl\u0131\u011f\u0131n\u0131n sa\u011fl\u0131\u011f\u0131m\u0131z\u0131 nas\u0131l etkiledi\u011fine dair olas\u0131 bir a\u00e7\u0131klama getirdi\u011fini s\u00f6yledi ve ekledi: \u201cS\u0131cakl\u0131\u011f\u0131n d\u00fc\u015f\u00fck oldu\u011fu k\u0131\u015f aylar\u0131nda grip ve so\u011fuk alg\u0131nl\u0131\u011f\u0131 salg\u0131nlar\u0131n\u0131n daha k\u00f6t\u00fcye gitme e\u011filimi oldu\u011funu bir s\u00fcredir biliyoruz. Ayr\u0131ca, daha y\u00fcksek s\u0131cakl\u0131klarda ya\u015fayan fareler ate\u015fli hastal\u0131klara ve kansere yakaland\u0131\u011f\u0131nda daha az ac\u0131 \u00e7ekiyor. Bu de\u011fi\u015fiklikler art\u0131k farkl\u0131 s\u0131cakl\u0131klarda, de\u011fi\u015fmi\u015f ba\u011f\u0131\u015f\u0131kl\u0131k cevaplar\u0131 olarak a\u00e7\u0131klanabilir.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":" Warwick ve Manchester \u00dcniversitesi\u2019nden matematik\u00e7i ve biyologlardan olu\u015fan bir grubun yapt\u0131\u011f\u0131 ara\u015ft\u0131rmaya g\u00f6re, v\u00fccudumuzun s\u0131cakl\u0131\u011f\u0131 ne kadar y\u00fcksek olursa, v\u00fccudumuzun t\u00fcm\u00f6rlere, yaralara ve enfeksiyonlara kar\u015f\u0131 sava\u015fmakla g\u00f6revli olan savunma sistemi o kadar h\u0131zlan\u0131yor. Ara\u015ft\u0131rmac\u0131lar, v\u00fccut s\u0131cakl\u0131\u011f\u0131ndaki ufak tefek y\u00fckselmelerin (ate\u015flenme esnas\u0131nda oldu\u011fu gibi) enfeksiyonlara verilen tepkiyi kontrol eden h\u00fccresel \u201csaat\u201d h\u0131z\u0131n\u0131 artt\u0131rd\u0131\u011f\u0131n\u0131 ve bu yeni […]<\/p>\n","protected":false},"author":871,"featured_media":27091,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19,21,33],"tags":[3545,3542,2413,3544,3543],"class_list":["post-27090","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","category-biyoloji","category-saglik-bilimleri","tag-a20-proteini","tag-atesli-hastaliklar","tag-bagisiklik-sistemi","tag-nf-kb","tag-vucut-isisi-ve-bagisiklik"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t
\n34 derecelik v\u00fccut s\u0131cakl\u0131\u011f\u0131nda, NF-kB saati yava\u015flamaya ba\u015flar. 37 derecedeki v\u00fccut s\u0131cakl\u0131\u011f\u0131ndan daha y\u00fcksek s\u0131cakl\u0131klarda (40 derece ate\u015flenmeler gibi) ise NF-kB saati h\u0131zlan\u0131r. Warwick Sistem Biyoloji Merkezi\u2019ndeki matematik\u00e7iler, s\u0131cakl\u0131k art\u0131\u015flar\u0131n\u0131n d\u00f6ng\u00fc h\u0131z\u0131n\u0131 nas\u0131l art\u0131rd\u0131\u011f\u0131n\u0131 hesaplad\u0131. Bu s\u00fcre\u00e7te, iltihapl\u0131 hastal\u0131klar\u0131 \u00f6nlemek i\u00e7in gerekli olan A20 ad\u0131 verilen proteinin kritik bir role sahip olmas\u0131 gerekti\u011fi \u00f6n s\u00fcr\u00fcld\u00fc. Ara\u015ft\u0131rmac\u0131lar daha sonra h\u00fccrelerden A20 isimli proteini \u00e7\u0131kartt\u0131. Bu i\u015flemin sonucunda, NF-kB saatinin s\u0131cakl\u0131k art\u0131\u015flar\u0131na kar\u015f\u0131 olan hassasiyetini kaybetti\u011fini g\u00f6rd\u00fcler.<\/p>\n
\nWarwick \u00dcniversitesi\u2019nden matematik\u00e7i Dan Woodcock \u015funlar\u0131 s\u00f6yledi: \u201cBu, h\u00fccrelerin matematiksel modellerinin, yararl\u0131 yeni biyolojik anlay\u0131\u015fa nas\u0131l y\u00f6nlendirebilece\u011finin g\u00fczel bir \u00f6rne\u011fidir.\u201d<\/p>\n