{"id":27206,"date":"2018-07-05T08:04:36","date_gmt":"2018-07-05T05:04:36","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=27206"},"modified":"2018-07-05T12:28:18","modified_gmt":"2018-07-05T09:28:18","slug":"ucuk-deyip-gecmeyin-alzheimer-ile-ucuk-virusu-arasinda-olasi-bir-baglanti-mi","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2018\/07\/05\/ucuk-deyip-gecmeyin-alzheimer-ile-ucuk-virusu-arasinda-olasi-bir-baglanti-mi","title":{"rendered":"U\u00e7uk deyip ge\u00e7meyin! Alzheimer ile u\u00e7uk vir\u00fcs\u00fc aras\u0131nda olas\u0131 bir ba\u011flant\u0131 m\u0131?"},"content":{"rendered":"

Joel Dudley ve \u00e7al\u0131\u015fma arkada\u015flar\u0131 Alzheimer hastal\u0131\u011f\u0131na kar\u015f\u0131 yeni bir tedavi y\u00f6ntemi geli\u015ftirmek \u00fczere veri setleri \u00fczerinde ara\u015ft\u0131rma yaparlarken \u015fa\u015f\u0131rt\u0131c\u0131 bir ili\u015fkiye rastlad\u0131lar. \u0130nceledikleri beyinlerin b\u00fcy\u00fck bir \u00e7o\u011funlu\u011funda u\u00e7uk vir\u00fcs\u00fc enfeksiyonuna dair belirtiler bulunmaktayd\u0131. \u201cBunun \u015fa\u015f\u0131lacak nesi var? Neredeyse herkes bu vir\u00fcse maruz kal\u0131yor\u201d diyebilirsiniz. Ancak i\u015fin \u015fa\u015f\u0131rt\u0131c\u0131 olan yan\u0131, Alzheimer hastal\u0131\u011f\u0131ndan mustarip bireylerin beyinleri di\u011fer sa\u011fl\u0131kl\u0131 insanlar\u0131n beyinlerinden \u00e7ok daha y\u00fcksek seviyede vir\u00fcs DNA\u2019s\u0131n\u0131 bar\u0131nd\u0131r\u0131yor olmas\u0131.
\n21 Haziran\u2019da Neuron<\/em>\u2019da yay\u0131nlanan \u00e7al\u0131\u015fmada ara\u015ft\u0131rmac\u0131lar, yayg\u0131n olarak g\u00f6r\u00fclen bir \u00e7ocuk hastal\u0131\u011f\u0131 olan k\u0131zam\u0131k\u00e7\u0131kla ili\u015fkilendirilmekte olan \u00f6zellikle iki u\u00e7uk t\u00fcr\u00fcnde \u00e7ok y\u00fcksek HHV-6 ve HHV-7 de\u011ferlerine rastlad\u0131klar\u0131n\u0131 raporlad\u0131lar.<\/p>\n

U\u00e7uk vir\u00fcs\u00fcn\u00fcn Alzheimer olu\u015fumuna katk\u0131da bulunup bulunmad\u0131\u011f\u0131 ya da vir\u00fcs\u00fcn enfeksiyon ge\u00e7tikten sonra h\u00e2l\u00e2 v\u00fccutta bar\u0131n\u0131yor olmas\u0131ndan dolay\u0131 m\u0131 Alzheimer hastalar\u0131n\u0131n bu vir\u00fcslere daha duyarl\u0131 oldu\u011fu belirsizli\u011fini korumakta. Ayr\u0131ca, genetik fakt\u00f6rler de bireyin Alzheimer\u2019a yakalanma riski \u00fczerinde \u00f6nemli bir etkiye sahip. Ara\u015ft\u0131rmac\u0131lar vir\u00fcslerin, sonu\u00e7lar her ne kadar belirsiz olursa olsun Alzheimer hastal\u0131\u011f\u0131yla ili\u015fkilendirilen genlerle direk olarak etkile\u015fimi oldu\u011funu ke\u015ffetti.<\/p>\n

\"\"
Alzheimer’\u0131n beyinde neden oldu\u011fu am\u0131loid-beta tabakalar\u0131n\u0131n bir tasviri. \u00a9 Selvanegra\/ Istockphoto<\/figcaption><\/figure>\n

Ke\u015fif sonras\u0131nda Dudley kendini, bula\u015f\u0131c\u0131 patojenler ile dejeneratif beyin hastal\u0131\u011f\u0131 aras\u0131nda bir ba\u011flant\u0131 oldu\u011funu savunan ve savunmayan biliminsanlar\u0131n\u0131n tart\u0131\u015fmalar\u0131n\u0131n ortas\u0131nda buldu. Clevlend Klini\u011fi\u2019nde n\u00f6rolog olarak \u00e7al\u0131\u015fan James Leverenz\u2019e g\u00f6re bu tart\u0131\u015fman\u0131n bir nedeni de u\u00e7uk vir\u00fcslerinin her yerde olduk\u00e7a yayg\u0131n bir bi\u00e7imde bulunmas\u0131 ve neredeyse her insan\u0131n bu vir\u00fcs\u00fc ta\u015f\u0131yor olmas\u0131. U\u00e7uk gibi yayg\u0131n bir vir\u00fcs\u00fcn, insan\u0131n hayat\u0131n\u0131 tam anlam\u0131yla cehenneme \u00e7eviren b\u00f6ylesi y\u0131k\u0131c\u0131 bir hastal\u0131\u011fa katk\u0131da bulunabilece\u011fi fikri on y\u0131llard\u0131r tart\u0131\u015f\u0131lmaktayd\u0131 ve bu fikir hi\u00e7bir ara\u015ft\u0131rmac\u0131 a\u00e7\u0131s\u0131ndan olas\u0131 g\u00f6r\u00fcnm\u00fcyordu.<\/p>\n

Alzheimer (T\u00fcrkiye\u2019de yakla\u015f\u0131k alt\u0131 y\u00fcz bin ki\u015fi bu hastal\u0131kla bo\u011fu\u015fuyor) \u00fczerine yap\u0131lan geleneksel ara\u015ft\u0131rma teknikleri hastal\u0131\u011f\u0131n iki ana \u00f6zelli\u011fine odaklan\u0131r: Beyindeki sinir h\u00fccreleri aras\u0131nda toplanan amiloid-beta plaklar\u0131 Amyloid beta (A\u03b2 or A-beta) 36 ve 43 amino asitlerini betimler. Bu amino asitler Alzheimer hastalar\u0131n\u0131n beyinlerindeki amiloid plakalar\u0131nda ana bile\u015fen olarak bulundu\u011fu i\u00e7in Alzheimer hastal\u0131\u011f\u0131 ile ili\u015fkilendirilir. \u0130kinci odak noktas\u0131 sinir h\u00fccrelerinin, yani n\u00f6ronlar\u0131n aras\u0131ndaki ileti\u015fimi engelleyen k\u0131vr\u0131lm\u0131\u015f protein ipleri olan tau yumaklar\u0131. Ancak, son zamanlardaki ara\u015ft\u0131rmalar, A-beta\u2019n\u0131n beyin h\u00fccreleri aras\u0131ndaki bo\u015fluklar\u0131 t\u0131kamak yerine asl\u0131nda bir \u00e7e\u015fit anti-mikrobiyal peptit gibi rol oynayarak patojenleri yakalayabilen amino asit zincirleri olarak i\u015flev g\u00f6rebilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmekte.<\/p>\n

Neuron<\/em> dergisinde yay\u0131mlanan yeni bir di\u011fer \u00e7al\u0131\u015fma ise, Alzheimer hastalar\u0131ndaki A-beta peptidlerinin u\u00e7uk gibi enfeksiyonlarla a\u015f\u0131r\u0131 aktif olabilece\u011fini ve beyni korumak i\u00e7in plaklar olu\u015fturuyor olabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmekte.<\/p>\n

Boston\u2019daki Massachusetts General Hospital\u2019dan n\u00f6rolog Rudolph Tanzi ve arkada\u015flar\u0131, yayg\u0131n ba\u015fka bir u\u00e7uk vir\u00fcs\u00fc olan HSV-1 enjekte edilen farelerde A-beta plak birikimlerinin daha h\u0131zl\u0131 olu\u015ftu\u011funu ke\u015ffetti. Bu fareler ayr\u0131ca, u\u00e7uk kaynakl\u0131 beyin iltihaplanmalar\u0131na daha az maruz kalmaktad\u0131r. Bu da A-beta\u2019n\u0131n do\u011fu\u015ftan gelen ba\u011f\u0131\u015f\u0131kl\u0131k sisteminde \u00f6nemli bir rol oynad\u0131\u011f\u0131n\u0131 g\u00f6stermektedir. Tanzi, u\u00e7uk vir\u00fcs\u00fcn\u00fcn en \u00e7ok Alzheimer ile ba\u011flant\u0131l\u0131 olmas\u0131na ra\u011fmen, bakteri ve mantarlar\u0131 i\u00e7eren di\u011fer patojenlerin de teorik olarak A-beta plaklar\u0131n\u0131 tetikleyebilece\u011fini s\u00f6yl\u00fcyor.<\/p>\n

Her iki \u00e7al\u0131\u015fmada da yer almayan Leverenz, potansiyel bir ba\u011flant\u0131ya ili\u015fkin kan\u0131tlar\u0131n desteklenmesiyle, Alzheimer hastal\u0131\u011f\u0131n\u0131 geleneksel y\u00f6ntemlerle ele alan ara\u015ft\u0131rmac\u0131lar\u0131n, bu yeni bulgulara ge\u00e7mi\u015fte yakla\u015ft\u0131klar\u0131ndan daha \u0131l\u0131ml\u0131 yakla\u015fabileceklerini belirtiyor ve: \u201cBa\u011f\u0131\u015f\u0131kl\u0131k sistemi ile bu tip bir Alzheimer hastal\u0131\u011f\u0131n\u0131n te\u015fhisi ger\u00e7ekten de \u00e7ok karma\u015f\u0131k. Bu fikri incelemek i\u00e7in muhtemelen biraz daha tarafs\u0131zl\u0131k gerek.\u201d diyor.<\/p>\n

Her iki makale de u\u00e7uk vir\u00fcs\u00fc ile Alzheimer hastal\u0131\u011f\u0131 aras\u0131ndaki ba\u011flant\u0131y\u0131 anlamak i\u00e7in daha fazla \u00e7al\u0131\u015fma yap\u0131lmas\u0131 gerekti\u011fini vurgulamakta. Chicago\u2019daki Alzheimer Derne\u011fi\u2019nden n\u00f6robilimci Keith Fargo, ki\u015finin geneti\u011finin bu yeni fikirle nas\u0131l bir araya gelece\u011finin belli olmad\u0131\u011f\u0131n\u0131 s\u00f6yl\u00fcyor ve ekliyor: \u201cAlzheimer hastal\u0131\u011f\u0131nda rol oynayan bir\u00e7ok genetik fakt\u00f6r var.”<\/p>\n

Joel Dudley, \u201c\u015eu an i\u00e7in tek bildi\u011fimiz \u015fey, Alzheimer hastal\u0131\u011f\u0131n\u0131n bula\u015f\u0131c\u0131 olmad\u0131\u011f\u0131. Alzheimer\u2019\u0131, demans (bunama) semptomlar\u0131 olan hastalardan \u2018yakalayamay\u0131z\u2019. U\u00e7uk vir\u00fcsleri bir rol oynuyor olsa bile, kesinlikle bir\u00e7ok di\u011fer fakt\u00f6r de bu hastal\u0131\u011f\u0131n geli\u015fmesine katk\u0131da bulunacakt\u0131r.\u201d diyor.<\/p>\n","protected":false},"excerpt":{"rendered":"

Joel Dudley ve \u00e7al\u0131\u015fma arkada\u015flar\u0131 Alzheimer hastal\u0131\u011f\u0131na kar\u015f\u0131 yeni bir tedavi y\u00f6ntemi geli\u015ftirmek \u00fczere veri setleri \u00fczerinde ara\u015ft\u0131rma yaparlarken \u015fa\u015f\u0131rt\u0131c\u0131 bir ili\u015fkiye rastlad\u0131lar. \u0130nceledikleri beyinlerin b\u00fcy\u00fck bir \u00e7o\u011funlu\u011funda u\u00e7uk vir\u00fcs\u00fc enfeksiyonuna dair belirtiler bulunmaktayd\u0131. \u201cBunun \u015fa\u015f\u0131lacak nesi var? Neredeyse herkes bu vir\u00fcse maruz kal\u0131yor\u201d diyebilirsiniz. Ancak i\u015fin \u015fa\u015f\u0131rt\u0131c\u0131 olan yan\u0131, Alzheimer hastal\u0131\u011f\u0131ndan mustarip bireylerin beyinleri […]<\/p>\n","protected":false},"author":812,"featured_media":27495,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19,21,1,231,33],"tags":[982,3639,3637,3638,3636],"class_list":["post-27206","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","category-biyoloji","category-genel","category-molekuler-biyoloji-ve-genetik","category-saglik-bilimleri","tag-alzheimer","tag-alzheimer-ve-ucuk","tag-herpes-virusu","tag-kizamikcik","tag-ucuk-hastaligi"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t