{"id":27558,"date":"2018-07-09T07:23:35","date_gmt":"2018-07-09T04:23:35","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=27558"},"modified":"2018-07-09T11:42:36","modified_gmt":"2018-07-09T08:42:36","slug":"vucuda-alinan-tuz-miktarinin-olumle-baglantisi-dogrulandi","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2018\/07\/09\/vucuda-alinan-tuz-miktarinin-olumle-baglantisi-dogrulandi","title":{"rendered":"V\u00fccuda al\u0131nan tuz miktar\u0131n\u0131n \u00f6l\u00fcmle ba\u011flant\u0131s\u0131 do\u011fruland\u0131"},"content":{"rendered":"

Yemeklerle al\u0131nan y\u00fcksek oranda tuzun y\u00fcksek kan bas\u0131nc\u0131yla do\u011frudan ili\u015fkisi oldu\u011fu uzun zamand\u0131r bilinen bir \u015feydi. Ancak, bunun kalp damar hastal\u0131klar\u0131 ve \u00f6l\u00fcmle direk bir ba\u011flant\u0131s\u0131 oldu\u011fu do\u011fru muydu? Ge\u00e7ti\u011fimiz g\u00fcnlerde Epidemiology<\/em> dergisinde yay\u0131mlanan, Brigham ve Kad\u0131nlar Hastanesi\u2019ndeki ara\u015ft\u0131rmac\u0131lar\u0131n y\u00fcr\u00fctt\u00fc\u011f\u00fc \u00e7al\u0131\u015fmada \u00e7oklu \u00f6l\u00e7\u00fcmler sayesinde bu tez do\u011frulanm\u0131\u015f gibi g\u00f6r\u00fcn\u00fcyor. Bu \u00e7al\u0131\u015fmada ortaya konan hassas sonu\u00e7lar sayesinde \u00f6nceki \u00e7al\u0131\u015fmalardaki \u00e7eli\u015fkili sonu\u00e7lar ge\u00e7ersiz k\u0131l\u0131nabilecek.<\/p>\n

Pek de iyi bir \u00fcn\u00fc olmayan sodyumun \u00f6l\u00e7\u00fcm\u00fc olduk\u00e7a zordur. En detayl\u0131 sorular\u0131 i\u00e7eren anketleri kullanmaya \u00e7al\u0131\u015fsan\u0131z bile hemen hemen hi\u00e7 kimse tam olarak g\u00fcnl\u00fck diyetlerinde ne kadar tuz ald\u0131\u011f\u0131n\u0131 bilemez ve s\u00f6yleyemez. Bu y\u00fczden al\u0131ma dair tahminler de zordur. Sodyum at\u0131m\u0131 en iyi \u00f6l\u00e7\u00fcm malzemesi oldu\u011fu i\u00e7in bu \u00e7al\u0131\u015fmada ara\u015ft\u0131rmac\u0131lar at\u0131m miktar\u0131n\u0131 ve bu at\u0131klar\u0131n biriktirilme yollar\u0131n\u0131 \u00e7e\u015fitlendirdi. B\u00f6ylece, \u00e7ok daha hassas \u00f6l\u00e7\u00fcmler elde ettiler.<\/p>\n

Bir ki\u015finin idrar \u00f6rne\u011finde bulunan tuz at\u0131m miktar\u0131, herhangi bir zamanda al\u0131nan tek bir idrar \u00f6rne\u011fiyle \u00f6l\u00e7\u00fclebilir. Bununla birlikte, g\u00fcn i\u00e7inde idrardaki tuz miktar\u0131 dalgalanma g\u00f6sterece\u011finden asl\u0131nda yirmi d\u00f6rt saat boyunca t\u00fcm idrar\u0131n toplanarak bir sonu\u00e7 al\u0131nmaya \u00e7al\u0131\u015f\u0131lmas\u0131 daha hassas bir \u00f6l\u00e7\u00fcm ortaya koyacakt\u0131r. Ayr\u0131ca, ki\u015finin sodyum al\u0131m miktar\u0131 g\u00fcnden g\u00fcne de de\u011fi\u015fiklik g\u00f6sterebilece\u011finden, de\u011fi\u015fik g\u00fcnlerde al\u0131nan yirmi d\u00f6rt saatlik idrar \u00f6rnekleri \u00e7ok daha belirleyici olacakt\u0131r.<\/p>\n

Daha \u00f6nceki \u00e7al\u0131\u015fmalarda Kawasaki metoduyla ve tek bir anda al\u0131nan tek bir idrar \u00f6rne\u011fi (spot idrar) kullan\u0131l\u0131rken; yeni \u00e7al\u0131\u015fmadaki ekip, pek \u00e7ok g\u00fcn boyunca alt\u0131n standart metoduna uygun olarak uygulanan diyetin i\u00e7erdi\u011fi tuz miktar\u0131n\u0131 hem ortalamaya uyan hem de ard\u0131\u015f\u0131k olmayan (rastgele zamanda) zamanlarda al\u0131nan idrar \u00f6rnekleriyle kar\u015f\u0131la\u015ft\u0131rarak bir sonu\u00e7 elde etmeye \u00e7al\u0131\u015ft\u0131lar. \u00c7al\u0131\u015fmaya, hipertansiyon \u00f6nleme tedavisi alan yakla\u015f\u0131k 3000 pre-hipertansiyon hastas\u0131 g\u00f6n\u00fcll\u00fc olarak kat\u0131ld\u0131.<\/p>\n

\u00c7al\u0131\u015fman\u0131n sonucunda, alt\u0131n standart metodu, artm\u0131\u015f sodyum al\u0131m\u0131yla \u00f6l\u00fcm riski art\u0131\u015f\u0131 aras\u0131nda direk bir ba\u011flant\u0131 tespit etmi\u015f oldu. Ekip ayr\u0131ca, daha \u00f6nce Kawasaki form\u00fcl\u00fcn\u00fcn a\u00e7\u0131\u011fa \u00e7\u0131kard\u0131\u011f\u0131 J \u015feklinde sonu\u00e7 e\u011frisinin hem d\u00fc\u015f\u00fck hem de y\u00fcksek d\u00fczeylerde tuz t\u00fcketiminin \u00f6l\u00fcm riskini art\u0131rmas\u0131 ile bir ba\u011flant\u0131s\u0131 olup olmad\u0131\u011f\u0131n\u0131 g\u00f6sterdi. Ayr\u0131ca, kendi ara\u015ft\u0131rmalar\u0131nda ortaya \u00e7\u0131kan paradoksal durumun, bu tip epidemiyolojik ara\u015ft\u0131rmalarda yap\u0131lan \u00f6l\u00e7\u00fcmlerin hassasl\u0131\u011f\u0131n\u0131 sa\u011flamak i\u00e7in tahmini \u00f6l\u00e7\u00fcmlerden \u00e7ok, kesin say\u0131sal verilerle yola \u00e7\u0131k\u0131lmas\u0131 gerektirdi\u011fini g\u00f6stermi\u015f oldu.<\/p>\n","protected":false},"excerpt":{"rendered":"

Yemeklerle al\u0131nan y\u00fcksek oranda tuzun y\u00fcksek kan bas\u0131nc\u0131yla do\u011frudan ili\u015fkisi oldu\u011fu uzun zamand\u0131r bilinen bir \u015feydi. Ancak, bunun kalp damar hastal\u0131klar\u0131 ve \u00f6l\u00fcmle direk bir ba\u011flant\u0131s\u0131 oldu\u011fu do\u011fru muydu? Ge\u00e7ti\u011fimiz g\u00fcnlerde Epidemiology dergisinde yay\u0131mlanan, Brigham ve Kad\u0131nlar Hastanesi\u2019ndeki ara\u015ft\u0131rmac\u0131lar\u0131n y\u00fcr\u00fctt\u00fc\u011f\u00fc \u00e7al\u0131\u015fmada \u00e7oklu \u00f6l\u00e7\u00fcmler sayesinde bu tez do\u011frulanm\u0131\u015f gibi g\u00f6r\u00fcn\u00fcyor. Bu \u00e7al\u0131\u015fmada ortaya konan hassas sonu\u00e7lar […]<\/p>\n","protected":false},"author":42,"featured_media":27560,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19,27],"tags":[],"class_list":["post-27558","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","category-bilim-kurgu"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t