{"id":28999,"date":"2018-09-02T05:00:17","date_gmt":"2018-09-02T02:00:17","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=28999"},"modified":"2018-09-02T00:04:50","modified_gmt":"2018-09-01T21:04:50","slug":"hucrenin-enerji-santrallerini-harekete-geciren-mekanizma-mitokondriyal-ribozomlar","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2018\/09\/02\/hucrenin-enerji-santrallerini-harekete-geciren-mekanizma-mitokondriyal-ribozomlar","title":{"rendered":"H\u00fccrenin enerji santrallerini harekete ge\u00e7iren mekanizma: Mitokondriyal Ribozomlar"},"content":{"rendered":"

Bat\u0131 Avustralya \u00dcniversitesi ve Harry Perkins T\u0131p Ara\u015ft\u0131rmalar\u0131 Enstit\u00fcs\u00fc\u2019nde g\u00f6revli ara\u015ft\u0131rmac\u0131lar, h\u00fccrelerde enerji \u00fcreten \u201cfabrikalar\u0131n\u201d atomik yap\u0131s\u0131 ve i\u015flevi ile bu fabrikalar\u0131n \u00f6zellikle de ila\u00e7 tedavilerindeki i\u015fleyi\u015fini d\u00fczenleyen \u201cmakinelerin\u201d \u00e7al\u0131\u015fma sistemine ili\u015fkin temel bir ke\u015fif ger\u00e7ekle\u015ftirdi.<\/p>\n

Nature<\/em>\u2019da yay\u0131mlanan makaleye g\u00f6re; arabalar\u0131n motorlar\u0131na g\u00fc\u00e7 vermek i\u00e7in fosil yak\u0131tlardan elde edilen bir t\u00fcr enerjiye ihtiya\u00e7 duymas\u0131 gibi, canl\u0131 v\u00fccudunu olu\u015fturan her bir h\u00fccre de canl\u0131 taraf\u0131ndan t\u00fcketilen g\u0131day\u0131 yak\u0131t olarak kullan\u0131yor. G\u0131dalardan elde edilecek enerjinin ortaya \u00e7\u0131kar\u0131lmas\u0131 i\u00e7in v\u00fccudumuzdaki her bir h\u00fccre taraf\u0131ndan besin molek\u00fcllerini enerjiye d\u00f6n\u00fc\u015ft\u00fcren bir mekanizma i\u015fletiliyor. Bu metabolik reaksiyonlar zinciri, h\u00fccrenin \u201cmitokondri\u201d ad\u0131 verilen \u201cenerji makinesi\u201dnde ger\u00e7ekle\u015fiyor. Bilim \u00e7evrelerince y\u00fcr\u00fct\u00fclen bir\u00e7ok ara\u015ft\u0131rma da mitokondrilerin ya\u015fam i\u00e7in zorunlu bir organel oldu\u011funu ortaya koyuyor.<\/p>\n

\u2018Proteinleri olu\u015fturma s\u00fcrecini kontrol eden bir dizi gen\u2019<\/strong><\/p>\n

\u0130svi\u00e7re ve Avusturya\u2019da bulunan enstit\u00fclerin i\u015fbirli\u011fi ile y\u00fcr\u00fct\u00fclen \u00e7al\u0131\u015fmada yer alan Profes\u00f6r Filipovska, h\u00fccrenin \u201cenerji santrali\u201d olan mitokondrilerin t\u00fcm \u00f6karyotik h\u00fccrelerde bulundu\u011funu ve i\u00e7erdi\u011fi \u00e7ift katl\u0131 zar tabakas\u0131 nedeniyle prokaryotik ya\u015fam bi\u00e7imlerinde bulunmad\u0131\u011f\u0131n\u0131 ifade etti. Profes\u00f6r Filipovska, a\u00e7\u0131klamalar\u0131n\u0131 \u201cMitokondri, organel i\u00e7erisinde enerji \u00fcretilmesini sa\u011flayan kilit proteinleri olu\u015fturma s\u00fcrecini de kontrol eden bir dizi gen i\u00e7erir\u201d ifadeleri ile s\u00fcrd\u00fcrd\u00fc. Dr. Filipovska, ke\u015ffe dair a\u00e7\u0131klamas\u0131nda \u015funlar\u0131 kaydetti:<\/p>\n

\"\"
Akci\u011fer dokusundan izole edilmi\u015f h\u00fccrede bulunan mitokondrilerin mikroskop alt\u0131ndaki g\u00f6r\u00fcnt\u00fcs\u00fc.<\/figcaption><\/figure>\n

\u201cMitokondri genomu (Mitokondriyal DNA) yoluyla \u00fcretilen proteinler, mitokondri i\u00e7erisinde enerji \u00fcretimi i\u00e7in esast\u0131r. Yap\u0131lan son \u00e7al\u0131\u015fma ile \u2018Mitokondriyal Ribozom\u2019 ad\u0131 verilen bu proteinlerin atom yap\u0131s\u0131 ve enerji \u00fcretimini nas\u0131l ger\u00e7ekle\u015ftirdi\u011fi ortaya konmu\u015ftur. Mitokondrinin enerji \u00fcretimine odakl\u0131 mekanizmas\u0131; bahsedilen proteinlerin sentezlenmesinden, bu proteinler mitokondri i\u00e7erisinde gerekli yere konumlanana kadar bloke halde bulunuyor. Bu durum olduk\u00e7a farkl\u0131 ve bu \u00e7al\u0131\u015fma daha \u00f6nce do\u011fada rastlamad\u0131\u011f\u0131m\u0131z bir mekanizman\u0131n varl\u0131\u011f\u0131n\u0131 ortaya \u00e7\u0131kar\u0131yor.\u201d<\/p>\n

\u2018Yeni modeller geli\u015ftiriliyor\u2019<\/strong><\/p>\n

Dr. Filipovska, bulu\u015fun ila\u00e7 tedavileri i\u00e7in yeni bir molek\u00fcler mekanizman\u0131n kurulmas\u0131 a\u00e7\u0131s\u0131ndan da olduk\u00e7a faydal\u0131 olaca\u011f\u0131n\u0131 ve bu ke\u015ffin ayn\u0131 zamanda, canl\u0131 sistemlerinin farkl\u0131 gereksinimleri alt\u0131nda mitokondrilerin nas\u0131l i\u015flev g\u00f6receklerine ili\u015fkin en ileri teknoloji g\u00fcc\u00fcn\u00fc de ortaya koydu\u011funu ifade etti. N\u00f6rodejeneratif ve metabolik hastal\u0131klar, kalp hastal\u0131klar\u0131, kanser, diyabet ve ya\u015flanmaya ba\u011fl\u0131 bir\u00e7ok hastal\u0131\u011f\u0131n mitokondriyal fonksiyon bozuklar\u0131 ile ilgili oldu\u011funun alt\u0131n\u0131 \u00e7izen Filipovska, bu ve benzeri molek\u00fcler ke\u015fiflerin, hastal\u0131k tedavilerinde ve ilaca dayal\u0131 tedavide b\u00fcy\u00fck \u00f6l\u00e7ekli s\u0131\u00e7rama yarataca\u011f\u0131n\u0131 ifade etti.<\/p>\n

Profes\u00f6r Filipovska, mitokondriyal kusurlar\u0131n hastal\u0131klara nas\u0131l etki etti\u011fini anlamak i\u00e7in, mitokondriyal ribozomun fonksiyonlar\u0131n\u0131n daha da derinden incelenece\u011fini vurgulayarak bir sonraki ad\u0131m\u0131n mitokondriyi daha detayl\u0131 bir ara\u015ft\u0131rma alan\u0131 olarak de\u011ferlendirmek oldu\u011funun alt\u0131n\u0131 \u00e7izdi. Filipovska, a\u00e7\u0131klamalar\u0131n\u0131 \u015f\u00f6yle sonland\u0131rd\u0131:<\/p>\n

\"\"
Mitokondri matriksinin ve tilakoid zar yap\u0131s\u0131n\u0131n mikroskop alt\u0131ndaki g\u00f6r\u00fcnt\u00fcs\u00fc.<\/figcaption><\/figure>\n

\u201cOlu\u015fturdu\u011fumuz modelleri, protein sentezinde ve enerji \u00fcretiminde ortaya \u00e7\u0131kan kusurlar\u0131 ge\u00e7ici olarak ortadan kald\u0131rabilen ila\u00e7lar\u0131n tasar\u0131m\u0131 i\u00e7in kullan\u0131yoruz. \u00c7al\u0131\u015fmam\u0131z\u0131n yeni evresinde, kusurlar\u0131 ve hastal\u0131klar\u0131 incelemek i\u00e7in yeni modeller geli\u015ftirmeye \u00e7al\u0131\u015f\u0131yoruz.\u201d<\/p>\n

Kaynak<\/strong><\/p>\n

1) https:\/\/phys.org\/news\/2018-08-revolutionary-view-cells-energy.html<\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Bat\u0131 Avustralya \u00dcniversitesi ve Harry Perkins T\u0131p Ara\u015ft\u0131rmalar\u0131 Enstit\u00fcs\u00fc\u2019nde g\u00f6revli ara\u015ft\u0131rmac\u0131lar, h\u00fccrelerde enerji \u00fcreten \u201cfabrikalar\u0131n\u201d atomik yap\u0131s\u0131 ve i\u015flevi ile bu fabrikalar\u0131n \u00f6zellikle de ila\u00e7 tedavilerindeki i\u015fleyi\u015fini d\u00fczenleyen \u201cmakinelerin\u201d \u00e7al\u0131\u015fma sistemine ili\u015fkin temel bir ke\u015fif ger\u00e7ekle\u015ftirdi. Nature\u2019da yay\u0131mlanan makaleye g\u00f6re; arabalar\u0131n motorlar\u0131na g\u00fc\u00e7 vermek i\u00e7in fosil yak\u0131tlardan elde edilen bir t\u00fcr enerjiye ihtiya\u00e7 duymas\u0131 gibi, […]<\/p>\n","protected":false},"author":1390,"featured_media":29000,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19,1],"tags":[292,4006,4007],"class_list":["post-28999","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","category-genel","tag-genetik","tag-mitokondri","tag-mitokondriyal-ribozom"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/28999","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1390"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=28999"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/28999\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media\/29000"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=28999"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=28999"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=28999"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}