NIEHS Klinik Ara\u015ft\u0131rma Birimi\u2019nin t\u0131bbi direkt\u00f6r\u00fc Do\u00e7ent Shepherd Schurman; sonu\u00e7lar\u0131n genetik \u00e7e\u015fitlili\u011fe, her bir ki\u015fiyi benzersiz k\u0131lan DNA\u2019daki ince farklara dayand\u0131\u011f\u0131n\u0131 belirtti. Schurman, \u201cB\u00fct\u00fcn insanlar ayn\u0131 genlere sahipler, ba\u015fka bir deyi\u015fle ayn\u0131 temel talimatlara sahipler, ancak baz\u0131 insanlarda bir DNA baz \u00e7ifti de\u011fi\u015fimi g\u00f6zlendi. Bu yayg\u0131n genetik varyasyon t\u00fcr\u00fc, tek n\u00fckleotid polimorfizmi veya SNP olarak adland\u0131r\u0131l\u0131r ve proteinlerin yap\u0131lma \u015feklini de\u011fi\u015ftirebilir ve bireyleri hastal\u0131\u011fa daha fazla veya daha az e\u011filimli hale getirebilir.\u201d a\u00e7\u0131klamalar\u0131nda bulundu.<\/p>\n Akci\u011fer hastal\u0131klar\u0131 uzman\u0131 Stavros Garantziotis; NIEHS Klinik Ara\u015ft\u0131rma Birimi\u2019nin t\u0131bbi direkt\u00f6r\u00fc ile birlikte, v\u00fccutta iltihapl\u0131 tepkilere yol a\u00e7an bir biyokimyasal yola\u011fa dahil olan d\u00f6rt SNP\u2019yi inceledi. SNP\u2019ler teker teker incelendi ve SNP\u2019lerin farkl\u0131 kombinasyonlar\u0131n\u0131n, kirlilik maruziyetinin yan\u0131 s\u0131ra ast\u0131m gibi enflamatuar hastal\u0131\u011f\u0131 olan bir ki\u015fide semptomlar\u0131 daha da k\u00f6t\u00fcle\u015ftirip k\u00f6t\u00fcle\u015ftiremeyece\u011fine y\u00f6nelik \u00e7al\u0131\u015fmalar yap\u0131ld\u0131.<\/p>\n \u2018Ana yollara daha yak\u0131n b\u00f6lgelerde hava kirlili\u011fi d\u00fczeyleri daha y\u00fcksek\u2019<\/strong><\/p>\n Schurman ve Garantziotis; ast\u0131m\u0131 olan 2704 kat\u0131l\u0131mc\u0131 hakk\u0131nda bilgi toplad\u0131. Kat\u0131l\u0131mc\u0131lar, SNP verileri kullan\u0131larak \u00fc\u00e7 gruba ayr\u0131ld\u0131: Birinci grup hava kirlili\u011fine \u00e7ok hassas olanlar, bu gruptakilerin iltihaplanma olas\u0131l\u0131\u011f\u0131 y\u00fcksektir. \u0130kinciler, hava kirlili\u011finden etkilenmeyenler, bu gruptakilerin iltihaplanma olas\u0131l\u0131\u011f\u0131 olduk\u00e7a d\u00fc\u015f\u00fckt\u00fcr. Son kategori ise, bu iki gruba da dahil olmayan ve iki grubun aras\u0131nda bir form olanlar. Bu \u00e7al\u0131\u015fma s\u0131ras\u0131nda kat\u0131l\u0131mc\u0131lar\u0131n yerle\u015fim yerleri baz al\u0131nd\u0131. Ana yollara daha yak\u0131n b\u00f6lgelerde hava kirlili\u011fi d\u00fczeylerinin daha y\u00fcksek oldu\u011fu verisinden hareketle, kat\u0131l\u0131mc\u0131lar kategorilere ayr\u0131ld\u0131.<\/p>\n Ara\u015ft\u0131rmac\u0131lar, hava kirlili\u011fe hassas olanlar ve a\u011f\u0131r \u015fekilde seyahat edilen yollara daha yak\u0131n b\u00f6lgelerde oturan ast\u0131m hastalar\u0131n\u0131n, di\u011fer gruplara g\u00f6re nefes alma, g\u00f6\u011f\u00fcs a\u011fr\u0131s\u0131, \u00f6ks\u00fcr\u00fck ve h\u0131r\u0131lt\u0131 gibi en k\u00f6t\u00fc ast\u0131m semptomlar\u0131na sahip olduklar\u0131 bulgusuna ula\u015ft\u0131. Buna kar\u015f\u0131l\u0131k, yo\u011fun trafi\u011fin bulundu\u011fu yollardan uzakta ya\u015fayan ast\u0131m hastalar\u0131nda daha hafif semptomlar vard\u0131. Garantziotis, \u00e7al\u0131\u015fman\u0131n ast\u0131m hastalar\u0131n\u0131n ya\u015fam kalitesini b\u00fcy\u00fck \u00f6l\u00e7\u00fcde art\u0131rabilece\u011fi ifade ederek, \u201cBu ara\u015ft\u0131rmaya dayanarak, trafik kirlili\u011fine maruz kalan ve hava kirlili\u011fine hassasiyeti olanlar\u0131n, evlerine HEPA filtreleri gibi hava ar\u0131tma cihazlar\u0131 almalar\u0131n\u0131 \u00f6nerdik\u201d a\u00e7\u0131klamalar\u0131nda bulundu.<\/p>\n NIEHS Klinik Direkt\u00f6r\u00fc Janet Hall; sonu\u00e7lar\u0131n, hastal\u0131\u011f\u0131n ilerlemesinde gen-\u00e7evre etkile\u015fimlerinin \u00f6nemini vurgulad\u0131\u011f\u0131n\u0131 s\u00f6yledi. Hall, \u015f\u00f6yle devam etti:<\/p>\n \u201cBu ara\u015ft\u0131rma, hastal\u0131k \u00f6nleme konusunda ki\u015fisel d\u00fczeyde nas\u0131l yakla\u015fabilece\u011fimizin harika bir \u00f6rne\u011fidir ve hastal\u0131klara y\u00f6nelik tedavilerimizi bireysel hale getirmemizi de sa\u011flar. Bu \u015fekilde tedavilerimiz ve koruyucu \u00f6nlemlerimizle daha verimli olabilirken ayn\u0131 zamanda sa\u011fl\u0131k bak\u0131m maliyetlerini de d\u00fc\u015f\u00fcrm\u00fc\u015f oluruz.\u201d<\/p>\n Kaynak<\/strong><\/p>\n 1) https:\/\/medicalxpress.com\/news\/2018-08-genetics-pollution-severity-asthma-symptoms.html<\/p>\n 2) Foto\u011fraflar i\u00e7in kaynak: Fine Art America<\/p>\n","protected":false},"excerpt":{"rendered":" Ulusal Sa\u011fl\u0131k Enstit\u00fcs\u00fc ve Rice \u00dcniversitesi\u2019nden ara\u015ft\u0131rmac\u0131lara g\u00f6re; belirli bir genetik profili olan ki\u015filer, trafik kirlili\u011fine maruz kalman\u0131n ard\u0131ndan daha yo\u011fun ast\u0131m semptomlar\u0131 sergiliyorlar. Scientific Reports\u2019ta yay\u0131mlanan \u00e7al\u0131\u015fmaya g\u00f6re; bu genetik profilden yoksun ast\u0131m hastalar\u0131n\u0131n trafik kirlili\u011fine kar\u015f\u0131 ayn\u0131 duyarl\u0131l\u0131\u011fa sahip olmad\u0131klar\u0131 ortaya \u00e7\u0131kt\u0131. Ayn\u0131 durumdaki hastalar, k\u00f6t\u00fc ast\u0131m semptomlar\u0131n\u0131 ya\u015fam\u0131yorlar. Bu \u00e7al\u0131\u015fma; biliminsanlar\u0131n\u0131, bireye […]<\/p>\n","protected":false},"author":1390,"featured_media":29076,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[4016,292,1502],"class_list":["post-29075","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-astim","tag-genetik","tag-hava-kirliligi"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/29075","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1390"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=29075"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/29075\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media\/29076"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=29075"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=29075"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=29075"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"\"](\"https:\/\/bilimvegelecek.com.tr\/wp-content\/uploads\/2018\/09\/2-001-226x300.jpg\")
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