{"id":36072,"date":"2019-08-10T03:20:14","date_gmt":"2019-08-10T00:20:14","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=36072"},"modified":"2019-08-08T14:53:01","modified_gmt":"2019-08-08T11:53:01","slug":"yeni-calismaya-gore-plasenta-tahmin-edilenden-daha-az-mikroorganizma-iceriyor","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2019\/08\/10\/yeni-calismaya-gore-plasenta-tahmin-edilenden-daha-az-mikroorganizma-iceriyor","title":{"rendered":"Yeni \u00e7al\u0131\u015fmaya g\u00f6re plasenta, tahmin edilenden daha az mikroorganizma i\u00e7eriyor"},"content":{"rendered":"

Yeni \u00e7al\u0131\u015fma, konuya ili\u015fkin \u00f6nceki \u00e7al\u0131\u015fmalar\u0131n aksine insan plasentas\u0131n\u0131n b\u00fcy\u00fck oranda mikroorganizma i\u00e7ermeyen bir yap\u0131s\u0131n\u0131n oldu\u011funu ortaya koydu. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131na g\u00f6re; b\u00fcy\u00fcmekte olan bir fet\u00fcs\u00fc besleme ve koruma g\u00f6revi olan plasenta yap\u0131s\u0131n\u0131n bakteri bulundurup bulundurmad\u0131\u011f\u0131 y\u0131llard\u0131r tart\u0131\u015fmal\u0131 bir konu olarak g\u00fcndemdeydi.<\/p>\n

Cambridge \u00dcniversitesi\u2019nden molek\u00fcler biyolog Stephen Charnock-Jones ve beraberindeki ara\u015ft\u0131rmac\u0131lar, \u00e7al\u0131\u015fma yapmak i\u00e7in plasenta \u00f6rnekleri toplad\u0131 ve mikroorganizmalar\u0131n plasentada toplanarak burada bir mikrobiyom olu\u015fumuna neden olup olmad\u0131klar\u0131n\u0131 ara\u015ft\u0131rd\u0131. Konuya ili\u015fkin olarak a\u00e7\u0131klama yapan Charnock-Jones, \u201cBu ara\u015ft\u0131rma konusunu nesnel olarak test edebilece\u011fimizi d\u00fc\u015f\u00fcnd\u00fck\u201ddedi.<\/p>\n

B\u00f6ylelikle Charnock-Jones ve ekibi, do\u011fumlar\u0131n ard\u0131ndan toplanan 500\u2019\u00fc a\u015fk\u0131n plasenta \u00f6rne\u011fi \u00fczerinde incelemelerde bulundu. Daha sonra \u00e7e\u015fitli a\u015famalardan ge\u00e7irilerek \u00fczerinde \u00e7al\u0131\u015fma yapmak i\u00e7in uygun hale getirilen \u00f6rneklerden bakteri DNA\u2019s\u0131 arama \u00e7al\u0131\u015fmalar\u0131na ge\u00e7ildi. 31 Temmuz g\u00fcn\u00fc Nature dergisinde yay\u0131nlanan makaleye g\u00f6re; genel itibariyle plasenta \u00f6rnekleri \u00fczerinde \u00e7ok az say\u0131da bakteri genomu bulunuyordu. Bu konuya ili\u015fkin a\u00e7\u0131klama yapan ekip, bu DNA \u00f6rneklerinin bir\u00e7o\u011funun laboratuvar ara\u00e7lar\u0131ndan, do\u011fum kanal\u0131ndan ve bazen de \u00f6rneklerin y\u0131kand\u0131\u011f\u0131 tuz \u00e7\u00f6zeltisinden geldi\u011fini ifade etti.<\/p>\n

\"\"
Mikroorganizmalar\u0131n plasentada toplanarak burada bir mikrobiyom olu\u015fumuna neden olup olmad\u0131klar\u0131 ara\u015ft\u0131r\u0131ld\u0131<\/figcaption><\/figure>\n

Ara\u015ft\u0131rmac\u0131lar plasentadan gelen bakteriyel sinyallere odaklanmak i\u00e7in testlerden sadece birinde ortaya \u00e7\u0131kan bakterileri eledi. Benzer \u015fekilde, ara\u015ft\u0131rmac\u0131lar taraf\u0131ndan kullan\u0131lan tuz \u00e7\u00f6zeltisi, ba\u015fka reaktifler ve DNA dizileme cihazlar\u0131 gibi laboratuvar \u00fcr\u00fcnlerinin kullan\u0131m\u0131 ile ortaya \u00e7\u0131kan bakteriyel sinyaller de ekip taraf\u0131ndan d\u0131\u015fland\u0131. Tekniklerine dair a\u00e7\u0131klama yapan Charnock-Jones, \u201c\u00c7al\u0131\u015fman\u0131n hangi ay yap\u0131ld\u0131\u011f\u0131, hangi reaktiflerin kullan\u0131ld\u0131\u011f\u0131 veya \u00e7al\u0131\u015fmay\u0131 hangi teknisyenin yapt\u0131\u011f\u0131 \u00f6nemli de\u011fil. Bunlardan hi\u00e7biri, ald\u0131\u011f\u0131m\u0131z sinyalin ger\u00e7ek bir bakteriye ait olup olmad\u0131\u011f\u0131n\u0131 ortaya \u00e7\u0131karm\u0131yor\u201d a\u00e7\u0131klamalar\u0131nda bulundu.<\/p>\n

Ara\u015ft\u0131rmac\u0131lar, kontrol metodu olarak insanlarda bulunmayan Salmonella bongori bakterisi \u00fczerinde \u00e7al\u0131\u015fma yapt\u0131lar. Deneyler, bu bakterinin \u00f6rneklerde olduk\u00e7a istisnai bir bi\u00e7imde bulundu\u011funu g\u00f6sterdi. Plasenta \u00f6rneklerinin yakla\u015f\u0131k y\u00fczde 5\u2019inde fet\u00fcs ve yenido\u011fanlar i\u00e7in tehlikeli olabilecek B Streptococcus bakterisine de rastland\u0131. Bu \u00f6rnekler, \u00e7al\u0131\u015fmalarda kullan\u0131lan \u00f6rneklere ait sa\u011fl\u0131k sonu\u00e7lar\u0131na ba\u011fl\u0131 de\u011fildi ve bu vakalar\u0131n g\u00f6r\u00fclme s\u0131kl\u0131\u011f\u0131 olduk\u00e7a azd\u0131.<\/p>\n

Konu h\u00e2l\u00e2 daha tart\u0131\u015fmal\u0131<\/strong>
\nDetroit’teki Wayne Devlet \u00dcniversitesi’nde bulunan Ulusal \u00c7ocuk Sa\u011fl\u0131\u011f\u0131 ve \u0130nsan Geli\u015fimi Enstit\u00fcs\u00fc’n\u00fcn Perinatoloji Ara\u015ft\u0131rma \u015eubesi’nde kad\u0131n do\u011fum uzman\u0131 ve jinekolog olarak \u00e7al\u0131\u015fan Roberto Romero, \u00e7al\u0131\u015fmaya ili\u015fkin olarak yapt\u0131\u011f\u0131 a\u00e7\u0131klamada, \u201c\u00c7al\u0131\u015fman\u0131n bulgular\u0131 olduk\u00e7a ikna edici. G\u00f6zlemledi\u011fimiz sinyallerin, reaktifler ve ekipmanlar yoluyla olu\u015fan kontaminasyondan kaynakland\u0131\u011f\u0131n\u0131 ortaya \u00e7\u0131kard\u0131k\u201d dedi.<\/p>\n

Houston’daki Texas \u00c7ocuk Hastanesi’nde kad\u0131n do\u011fum uzman\u0131 ve anne-fetal t\u0131p uzman\u0131 olarak \u00e7al\u0131\u015fan Kjersti Aagaard ise, \u201cBu \u00e7al\u0131\u015fman\u0131n \u00e7\u0131kt\u0131lar\u0131 herkes taraf\u0131ndan kabul g\u00f6rmeyecektir. Bu \u00e7al\u0131\u015fma baz\u0131 \u00f6nemli bakteriler \u00e7al\u0131\u015fma d\u0131\u015f\u0131nda b\u0131rak\u0131lacak \u015fekilde yap\u0131ld\u0131\u201da\u00e7\u0131klamalar\u0131nda bulundu. \u00d6rne\u011fin biliminsanlar\u0131, plasentada bulunan \u00e7e\u015fitli vajinal bakteri tiplerini, kontaminasyon olarak s\u0131n\u0131fland\u0131rd\u0131 ancak vajinada oldu\u011fu bilinen bakteriler, plasentaya ba\u011flanan uterusta da bulunmu\u015ftu. Bu durum da plasenta mikrobiyomuna dair kan\u0131tlar sunuyor\u201d a\u00e7\u0131klamalar\u0131nda bulundu. \u201cNeden bu bakterileri g\u00f6z ard\u0131 ediyoruz?\u201d diye soran Aagaard; plasentada, konuya ili\u015fkin daha \u00f6nceki \u00e7al\u0131\u015fmalar\u0131n i\u015faret etti\u011finden daha az bakteri bulundu\u011funu kabul ediyor ancak bu mikroorganizmalar\u0131n biyolojik \u00f6nemlerinden emin de\u011fil.<\/p>\n

\u00d6zetle bu \u00e7al\u0131\u015fma, plasentada bir mikrobiyom olarak tan\u0131mlanabilecek kadar bakteri bulunmad\u0131\u011f\u0131n\u0131 ortaya koysa da biliminsanlar\u0131, \u00e7al\u0131\u015fman\u0131n ileri a\u015famalar\u0131na da bak\u0131lmas\u0131 gerekti\u011fini s\u00f6yl\u00fcyor.<\/p>\n

Kaynak: https:\/\/www.sciencenews.org\/article\/new-study-challenges-idea-placenta-microbiome-bacteria?tgt=nr<\/p>\n","protected":false},"excerpt":{"rendered":"

Yeni \u00e7al\u0131\u015fma, konuya ili\u015fkin \u00f6nceki \u00e7al\u0131\u015fmalar\u0131n aksine insan plasentas\u0131n\u0131n b\u00fcy\u00fck oranda mikroorganizma i\u00e7ermeyen bir yap\u0131s\u0131n\u0131n oldu\u011funu ortaya koydu. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131na g\u00f6re; b\u00fcy\u00fcmekte olan bir fet\u00fcs\u00fc besleme ve koruma g\u00f6revi olan plasenta yap\u0131s\u0131n\u0131n bakteri bulundurup bulundurmad\u0131\u011f\u0131 y\u0131llard\u0131r tart\u0131\u015fmal\u0131 bir konu olarak g\u00fcndemdeydi. Cambridge \u00dcniversitesi\u2019nden molek\u00fcler biyolog Stephen Charnock-Jones ve beraberindeki ara\u015ft\u0131rmac\u0131lar, \u00e7al\u0131\u015fma yapmak i\u00e7in plasenta […]<\/p>\n","protected":false},"author":1390,"featured_media":36073,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[493,5185,4977,5184],"class_list":["post-36072","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-bakteri","tag-kontaminasyon","tag-mikroorganizma","tag-plasenta"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t