{"id":36120,"date":"2019-08-19T03:20:01","date_gmt":"2019-08-19T00:20:01","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=36120"},"modified":"2019-08-09T15:33:32","modified_gmt":"2019-08-09T12:33:32","slug":"yeni-calisma-colyak-hastaliginin-teshisini-kolaylastiracak-bir-metot-sunuyor","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2019\/08\/19\/yeni-calisma-colyak-hastaliginin-teshisini-kolaylastiracak-bir-metot-sunuyor","title":{"rendered":"Yeni \u00e7al\u0131\u015fma, \u00e7\u00f6lyak hastal\u0131\u011f\u0131n\u0131n te\u015fhisini kolayla\u015ft\u0131racak bir metot sunuyor"},"content":{"rendered":"

Biliminsanlar\u0131 taraf\u0131ndan yap\u0131lan yeni \u00e7al\u0131\u015fma, \u00e7\u00f6lyak hastas\u0131 olan ki\u015filerde gl\u00fctenli g\u0131da t\u00fcketiminin ard\u0131ndan neden mide bulant\u0131s\u0131 g\u00f6r\u00fcld\u00fc\u011f\u00fcn\u00fc ortaya \u00e7\u0131kard\u0131.<\/p>\n

7 A\u011fustos g\u00fcn\u00fc, Science Advances\u2019ta yay\u0131nlanan rapora g\u00f6re; ba\u011f\u0131\u015f\u0131kl\u0131\u011fa dair baz\u0131 h\u00fccreler, ki\u015fi gl\u00fctenli g\u0131da t\u00fckettikten k\u0131sa bir s\u00fcre sonra \u201csitokin\u201d ad\u0131 verilen ba\u011f\u0131\u015f\u0131kl\u0131k kimyasallar\u0131n\u0131 kana g\u00f6nderiyor. Bu ba\u011f\u0131\u015f\u0131kl\u0131k kimyasallar\u0131, ki\u015filerde mide bulant\u0131s\u0131na neden oluyor ve bu hastal\u0131\u011f\u0131n belirtilerini tetikliyor.<\/p>\n

Konuya dair \u00e7al\u0131\u015fmalar\u0131n\u0131 s\u00fcrd\u00fcren biliminsan\u0131 Robert Anderson, \u201cHastalar, gl\u00fctenli g\u0131da ile beslendiklerinde hem sitokinler hem de hastal\u0131k semptomlar\u0131nda art\u0131\u015f meydana geldi\u201d a\u00e7\u0131klamalar\u0131nda bulundu. Anderson, ayn\u0131 zamanda otoimm\u00fcn hastal\u0131klara kar\u015f\u0131 koruma geli\u015ftirmek i\u00e7in a\u015f\u0131 \u00e7al\u0131\u015fmalar\u0131nda bulunuyor. Asl\u0131nda biliminsanlar\u0131, hastal\u0131\u011fa dair pek \u00e7ok \u015feyi ge\u00e7mi\u015f \u00e7al\u0131\u015fmalar\u0131ndan do\u011fru biliyordu. Bu bilgilerden biri; CD4+ tipindeki T h\u00fccrelerinin bu\u011fday, arpa ve \u00e7avdarda bulunan gl\u00fcten proteinlerine tepki g\u00f6sterdikleri ve burada ger\u00e7ekle\u015fen reaksiyonlar zincirinin ince ba\u011f\u0131rsakta hasara yol a\u00e7t\u0131\u011f\u0131yd\u0131. Normalde bu tip T h\u00fccreleri, ki\u015fi gl\u00fctenli bir g\u0131da ile beslendikten bir iki g\u00fcn sonras\u0131na kadar bu kadar y\u00fcksek d\u00fczeyde tepkiler vermez. Ancak insanlar\u0131n y\u00fczde 1\u2019ini etkileyen bir otoimm\u00fcn bozukluk nedeniyle, genellikle gl\u00fcten t\u00fcketiminin ard\u0131ndan bir veya iki saatlik bir s\u00fcre sonras\u0131nda mide bulant\u0131s\u0131, a\u011fr\u0131 ve akabinde kusma \u015fikayetleri g\u00f6zlenir.<\/p>\n

\"\"
\u00c7\u00f6lyak hastalar\u0131n\u0131n rahats\u0131zlanmas\u0131na neden olan gl\u00fcten proteini, unlu g\u0131dalar\u0131n neredeyse tamam\u0131nda bulunur<\/figcaption><\/figure>\n

Anderson ve meslekta\u015flar\u0131, \u00e7al\u0131\u015fma s\u0131ras\u0131nda \u00e7\u00f6lyak hastal\u0131\u011f\u0131na sahip baz\u0131 bireylerin deri alt\u0131na gl\u00fcten peptitleri enjekte etti, baz\u0131lar\u0131na ise bu\u011fday unu ile kar\u0131\u015ft\u0131r\u0131lm\u0131\u015f bir i\u00e7ecek verdi. Ara\u015ft\u0131rmac\u0131lar, hastalar\u0131n bu g\u0131dalar\u0131 t\u00fcketiminden yakla\u015f\u0131k iki saat sonra IL-2 isimli bir sitokinin ve bahsi ge\u00e7en T h\u00fccreleri taraf\u0131ndan sal\u0131nan di\u011fer imm\u00fcn kimyasallar\u0131n seviyelerinde art\u0131\u015f meydana geldi\u011fini tespit etti. Hastal\u0131\u011fa sahip g\u00f6n\u00fcll\u00fclerde mide bulant\u0131s\u0131 g\u00f6zlenmeye ba\u015flad\u0131. Ara\u015ft\u0131rmaya kat\u0131lan g\u00f6n\u00fcll\u00fclerden baz\u0131lar\u0131n\u0131n sitokin seviyelerinde art\u0131\u015f devam ettik\u00e7e mide bulant\u0131s\u0131 \u015fikayetlerinde de art\u0131\u015f meydana geldi ve bu durumu kusma izledi.<\/p>\n

\u00c7al\u0131\u015fman\u0131n y\u00fcr\u00fct\u00fcc\u00fclerinden Anderson, \u201cBelirli bir T h\u00fccresi tipinin ve bu h\u00fccreler vas\u0131tas\u0131yla salg\u0131lanan sitokinlerin \u00e7\u00f6lyak hastal\u0131\u011f\u0131n\u0131n semptomlar\u0131na neden oldu\u011funu bilmek, gl\u00fcten ile reaksiyona giren T h\u00fccrelerinin bu semptomlar\u0131 meydana getirmesini engellemeye y\u00f6nelik tedavilere yol a\u00e7abilir\u201d a\u00e7\u0131klamalar\u0131nda bulundu. Doktorlar, kandaki IL-2 seviyesini \u00f6l\u00e7erek \u00e7\u00f6lyak hastal\u0131\u011f\u0131 te\u015fhisinin konulabilece\u011fini ve hastalara ard arda gl\u00fcten verilerek yap\u0131lan testlere ihtiya\u00e7 duyulmas\u0131n\u0131n \u00f6nlenebilece\u011fini s\u00f6yl\u00fcyorlar.<\/p>\n

Kaynak:<\/strong> https:\/\/www.sciencenews.org\/article\/why-people-celiac-disease-suffer-so-soon-after-eating-gl\u00fcten<\/p>\n","protected":false},"excerpt":{"rendered":"

Biliminsanlar\u0131 taraf\u0131ndan yap\u0131lan yeni \u00e7al\u0131\u015fma, \u00e7\u00f6lyak hastas\u0131 olan ki\u015filerde gl\u00fctenli g\u0131da t\u00fcketiminin ard\u0131ndan neden mide bulant\u0131s\u0131 g\u00f6r\u00fcld\u00fc\u011f\u00fcn\u00fc ortaya \u00e7\u0131kard\u0131. 7 A\u011fustos g\u00fcn\u00fc, Science Advances\u2019ta yay\u0131nlanan rapora g\u00f6re; ba\u011f\u0131\u015f\u0131kl\u0131\u011fa dair baz\u0131 h\u00fccreler, ki\u015fi gl\u00fctenli g\u0131da t\u00fckettikten k\u0131sa bir s\u00fcre sonra \u201csitokin\u201d ad\u0131 verilen ba\u011f\u0131\u015f\u0131kl\u0131k kimyasallar\u0131n\u0131 kana g\u00f6nderiyor. Bu ba\u011f\u0131\u015f\u0131kl\u0131k kimyasallar\u0131, ki\u015filerde mide bulant\u0131s\u0131na neden oluyor ve […]<\/p>\n","protected":false},"author":1390,"featured_media":36122,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[1194,5199,5200,1631,5201],"class_list":["post-36120","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-bagisiklik","tag-colyak","tag-gluten","tag-hastalik","tag-mide-bulantisi"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/36120","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1390"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=36120"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/36120\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media\/36122"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=36120"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=36120"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=36120"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}