{"id":36697,"date":"2019-09-06T03:20:45","date_gmt":"2019-09-06T00:20:45","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=36697"},"modified":"2019-09-05T14:50:24","modified_gmt":"2019-09-05T11:50:24","slug":"yeniden-programlanmis-kok-hucrelerle-kornea-nakli-ilk-kez-gerceklestirildi","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2019\/09\/06\/yeniden-programlanmis-kok-hucrelerle-kornea-nakli-ilk-kez-gerceklestirildi","title":{"rendered":"Yeniden programlanm\u0131\u015f k\u00f6k h\u00fccrelerle kornea nakli ilk kez ger\u00e7ekle\u015ftirildi"},"content":{"rendered":"

Yeniden programlanm\u0131\u015f k\u00f6k h\u00fccre kullan\u0131larak korneas\u0131 tedavi edilen ilk ki\u015fi Japonya\u2019dan bir kad\u0131n oldu.<\/p>\n

Japonya’da bulunan Osaka \u00dcniversitesi’nde \u00e7al\u0131\u015fma y\u00fcr\u00fcten g\u00f6z hastal\u0131klar\u0131 doktoru Kohji Nishida, 29 A\u011fustos tarihli bas\u0131n konferans\u0131nda bu hastan\u0131n g\u00f6z\u00fcn \u015feffaf koruyucu tabakas\u0131 korneay\u0131 yenilemekle y\u00fck\u00fcml\u00fc k\u00f6k h\u00fccrelerini (iPS) kaybetti\u011fini ve bu durumun g\u00f6r\u00fc\u015f\u00fc bulan\u0131kla\u015ft\u0131r\u0131p k\u00f6rl\u00fc\u011fe neden oldu\u011funu a\u00e7\u0131klad\u0131. Tedavi i\u00e7in, Nishida ara\u015ft\u0131rmac\u0131lar\u0131n yeniden programlanm\u0131\u015f pluripotent k\u00f6k h\u00fccrelerden kornea h\u00fccre tabakalar\u0131 \u00fcrettiklerini s\u00f6yledi. Bu iPS h\u00fccreler, don\u00f6rden al\u0131nan yeti\u015fkin deri h\u00fccrelerinin embriyonik k\u00f6k h\u00fccre benzeri duruma yeniden programlanmas\u0131 ile elde ediliyor ve kornea h\u00fccreleri gibi bir\u00e7ok h\u00fccre t\u00fcr\u00fcne d\u00f6n\u00fc\u015febiliyor. Nishida hastan\u0131n korneas\u0131n\u0131n \u015feffafl\u0131\u011f\u0131n\u0131 korudu\u011funu ve bir ay \u00f6nceki nakilden bu yana g\u00f6r\u00fc\u015f\u00fcn\u00fcn d\u00fczeldi\u011fini belirtti.<\/p>\n

\"\"
Biliminsanlar\u0131, iPS h\u00fccrelerini kullanarak organlarda iyile\u015ftirmeler yapabiliyor.<\/figcaption><\/figure>\n

Hasar g\u00f6rm\u00fc\u015f veya hastal\u0131kl\u0131 kornean\u0131n tedavisi g\u00fcn\u00fcm\u00fczde \u00e7o\u011funlukla kadaverik dokularla yap\u0131l\u0131yor, ancak Japonya dahil pek \u00e7ok \u00fclkede organ nakli i\u00e7in bekleme listesi olduk\u00e7a uzun. Bu nedenle ara\u015ft\u0131rmac\u0131lar tedavi ama\u00e7l\u0131 iPS h\u00fccreleri kullan\u0131m\u0131 gibi alternatif yollar ar\u0131yor. Kyoto \u00dcniversitesi’nde k\u00f6k h\u00fccre \u00fczerine \u00e7al\u0131\u015fma y\u00fcr\u00fcten biyolog Shinya Yamanaka\u2019n\u0131n kendisine Nobel Fizyoloji ve T\u0131p \u00f6d\u00fcl\u00fc getiren iPS h\u00fccrelerini geli\u015ftirdi\u011fi \u00e7al\u0131\u015fmas\u0131n\u0131n ard\u0131ndan Japonya, halen iPS h\u00fccrelerinin klinik kullan\u0131m\u0131nda \u00f6nc\u00fcl\u00fck yap\u0131yor. Kornea tedavisinin yani s\u0131ra, Japon doktorlar iPS h\u00fccrelerini omurilik zedelenmesi, Parkinson ve di\u011fer g\u00f6z hastal\u0131klar\u0131n tedavisinde de kullan\u0131yor.<\/p>\n

Japon haber ajans\u0131 Kyodo’da yer alan habere g\u00f6re ise Japonya Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131, iPS h\u00fccrelerinin insan kornea tedavisinde kullan\u0131m\u0131nda d\u00f6rt klinik teste izin verdi. Nishida, bir sonraki tedaviyi bu sene sonunda ger\u00e7ekle\u015ftirmeyi planlad\u0131\u011f\u0131n\u0131 ve be\u015f y\u0131l i\u00e7inde bu uygulamay\u0131 klinikte g\u00f6rmeyi umdu\u011funu a\u00e7\u0131klad\u0131.<\/p>\n

Kaynak :<\/strong> https:\/\/www.nature.com\/articles\/d41586-019-02597-2
\nhttps:\/\/english.kyodonews.net\/news\/2019\/08\/372d1fed233e-update1-japan-univ-conducts-worlds-1st-ips-transplant-for-corneal-disease.html<\/p>\n","protected":false},"excerpt":{"rendered":"

Yeniden programlanm\u0131\u015f k\u00f6k h\u00fccre kullan\u0131larak korneas\u0131 tedavi edilen ilk ki\u015fi Japonya\u2019dan bir kad\u0131n oldu. Japonya’da bulunan Osaka \u00dcniversitesi’nde \u00e7al\u0131\u015fma y\u00fcr\u00fcten g\u00f6z hastal\u0131klar\u0131 doktoru Kohji Nishida, 29 A\u011fustos tarihli bas\u0131n konferans\u0131nda bu hastan\u0131n g\u00f6z\u00fcn \u015feffaf koruyucu tabakas\u0131 korneay\u0131 yenilemekle y\u00fck\u00fcml\u00fc k\u00f6k h\u00fccrelerini (iPS) kaybetti\u011fini ve bu durumun g\u00f6r\u00fc\u015f\u00fc bulan\u0131kla\u015ft\u0131r\u0131p k\u00f6rl\u00fc\u011fe neden oldu\u011funu a\u00e7\u0131klad\u0131. Tedavi i\u00e7in, Nishida […]<\/p>\n","protected":false},"author":2114,"featured_media":36702,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[1986,1631,424,3355,1521],"class_list":["post-36697","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-goz","tag-hastalik","tag-kok-hucre","tag-kornea","tag-tedavi"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t