{"id":36727,"date":"2019-09-15T03:20:07","date_gmt":"2019-09-15T00:20:07","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=36727"},"modified":"2019-09-10T12:50:14","modified_gmt":"2019-09-10T09:50:14","slug":"en-olumcul-kanser-turu-olan-pankreas-kanserinin-tedavisinde-yeni-asama","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2019\/09\/15\/en-olumcul-kanser-turu-olan-pankreas-kanserinin-tedavisinde-yeni-asama","title":{"rendered":"En \u00f6l\u00fcmc\u00fcl kanser t\u00fcr\u00fc olan pankreas kanserinin tedavisinde yeni a\u015fama"},"content":{"rendered":"

Pankreas kanserinin tedavisi olduk\u00e7a zor bir kanser t\u00fcr\u00fc oldu\u011fu bilinir. Yeni ara\u015ft\u0131rmaya g\u00f6re bu durumun temel nedeni, pankreatik kanser h\u00fccrelerinin kan damarlar\u0131n\u0131 tahrip etmesidir. Kanser tedavisinde kullan\u0131lan ila\u00e7lar\u0131 hedef noktaya ula\u015ft\u0131racak olan kan damarlar\u0131n\u0131n tahrip edilmesi nedeniyle tedavi tam verim ile ger\u00e7ekle\u015ftirilemez.<\/p>\n

Yeni \u00e7al\u0131\u015fmayla elde edilen bilgilerle ilerleyen ara\u015ft\u0131rmac\u0131lar, t\u00fcm\u00f6r h\u00fccrelerinin kan damarlar\u0131n\u0131 nas\u0131l tahrip ettiklerini raporlad\u0131. \u00c7al\u0131\u015fma ekibi, t\u00fcm\u00f6r\u00fcn bu \u00f6l\u00fcmc\u00fcl ilerlemesinin arka plan\u0131ndaki molek\u00fcler temeli analiz edip, bu mekanizma bir \u00f6l\u00e7\u00fcde durduruldu\u011funda t\u00fcm\u00f6r b\u00fcy\u00fcmesinin yava\u015flad\u0131\u011f\u0131n\u0131 g\u00f6rd\u00fcler. Biliminsanlar\u0131 b\u00f6ylece t\u00fcm\u00f6r\u00fcn etraf\u0131nda bulunan kan damar\u0131 yo\u011funlu\u011funun da artt\u0131\u011f\u0131n\u0131 g\u00f6zlemlediler. 28 A\u011fustos g\u00fcn\u00fc Science Advances’te yay\u0131mlanan \u00e7al\u0131\u015fma \u00e7\u0131kt\u0131lar\u0131na g\u00f6re, kanser ila\u00e7lar\u0131n\u0131n etkisini g\u00f6stermesini engelleyen tahribat\u0131n \u00f6nlenmesiyle birlikte, daha y\u00fcksek oranda olumlu geri bildirim al\u0131nabilir.<\/p>\n

New York’ta bulunan Weill Cornell Medical College’da molek\u00fcler biyolog olarak \u00e7al\u0131\u015fma y\u00fcr\u00fcten Duc-Huy Nguyen, ara\u015ft\u0131rma s\u0131ras\u0131nda Pennsylvania \u00dcniversitesi’nde bulundu. \u00c7al\u0131\u015fmaya ili\u015fkin a\u00e7\u0131klamalarda bulunan Nguyen, \u201cT\u00fcm\u00f6r\u00fcn etraf\u0131nda bulunan kan damarlar\u0131n\u0131 kurtarabiliriz ve b\u00f6ylelikle t\u00fcm\u00f6r kitlesini k\u00fc\u00e7\u00fclten ila\u00e7lar\u0131n etkisi g\u00f6r\u00fclebilir ve kanserde gerileme sa\u011flanabilir. Ancak t\u00fcm\u00f6rlerde k\u00fc\u00e7\u00fcltme i\u015flemini \u015fu anki durumda ger\u00e7ekle\u015ftiremiyoruz\u201d dedi.<\/p>\n

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Pankreas, \u015feker d\u00fczenleyici hormonlar\u0131 salg\u0131layan bir organd\u0131r.<\/figcaption><\/figure>\n

Pankreas kanserinin en \u00f6l\u00fcmc\u00fcl kanserler aras\u0131nda oldu\u011fu bilinmekte. \u0130statistiki verilere g\u00f6re, 2019 y\u0131l\u0131nda hastal\u0131\u011fa yakalanma potansiyeli ta\u015f\u0131yan 56.770 Amerikal\u0131’n\u0131n y\u00fczde 90’\u0131ndan da fazlas\u0131 be\u015f y\u0131l i\u00e7inde ya\u015fam\u0131n\u0131 yitirecek. Ara\u015ft\u0131rmac\u0131lar, g\u00f6rece k\u00fc\u00e7\u00fck boyutta olan bu organ\u0131n \u00fczerinde \u00e7al\u0131\u015fmalar yapmaya uzun bir s\u00fcredir devam etmekte.\u00a0Bu organda g\u00f6zlenen kanser \u00fczerinde \u00e7al\u0131\u015fmalar\u0131n\u0131 s\u00fcrd\u00fcren Nguyen ve ekibi, haz\u0131rlad\u0131klar\u0131 deney d\u00fczene\u011finde canl\u0131l\u0131\u011f\u0131n\u0131 koruyan insan pankreas h\u00fccreleri, insan endotel h\u00fccreleri ve kan damar\u0131 kulland\u0131. \u0130lerleyen g\u00fcnlerde, kan damar\u0131n\u0131n t\u00fcm\u00f6r h\u00fccreleri taraf\u0131ndan istila edildi\u011fi g\u00f6zlendi. Buradaki endotel h\u00fccrelerinin de \u00f6lmeye ba\u015flamas\u0131 \u00fczerine t\u00fcm\u00f6r h\u00fccreleri, yok ettikleri endotel h\u00fccrelerinin yerini almaya ba\u015flad\u0131. Bu d\u00f6ng\u00fc hi\u00e7 yava\u015flamadan devam etti. Ara\u015ft\u0131rmaya kat\u0131lmayan ve Amerikan Kanser Derne\u011fi’nde \u00e7al\u0131\u015fma y\u00fcr\u00fcten biyolog Charles Saxe, \u00e7al\u0131\u015fmaya ili\u015fkin a\u00e7\u0131klamalarda bulunarak \u201cKanser ila\u00e7lar\u0131n\u0131n pankreas kanseri h\u00fccrelerine neden ula\u015famad\u0131klar\u0131n\u0131 a\u00e7\u0131klayan bu \u00e7al\u0131\u015fma olduk\u00e7a etkileyici. Daha fazla g\u00f6zlemin yap\u0131lmas\u0131, t\u00fcm\u00f6rlerin nas\u0131l bu kadar \u00e7abuk yay\u0131ld\u0131\u011f\u0131n\u0131 da a\u00e7\u0131klayabilir\u201d dedi.<\/p>\n

Ara\u015ft\u0131rmac\u0131lar daha sonraki a\u015famada, t\u00fcm\u00f6rlerin endotel h\u00fccrelerini \u00f6ld\u00fcrmesine yol a\u00e7an mekanizmay\u0131 ara\u015ft\u0131rd\u0131lar. \u0130lk olarak di\u011fer kanserlerde de t\u00fcm\u00f6r b\u00fcy\u00fcmesine neden olan TGF-beta isimli protein grubu \u00fczerinde durdular. Bu protein grubu \u00fczerinden ilerleyen ekip, en sonunda bu duruma neden olan esas proteini buldu: ALK7 resept\u00f6r proteini. ALK7 resept\u00f6r\u00fcn\u00fcn \u00e7al\u0131\u015fmas\u0131n\u0131n \u00f6nlenmesiyle birlikte kanser h\u00fccrelerinin endotel tabakada yaratt\u0131\u011f\u0131 tahribat \u00f6nlendi. Farelerde yap\u0131lan deneyler sonucunda ula\u015f\u0131lan bu mekanizman\u0131n, insanlarda ayn\u0131 bi\u00e7imde i\u015fleyip i\u015flemedi\u011fini anlamak i\u00e7in ek ara\u015ft\u0131rmalara ihtiya\u00e7 duyuldu\u011fu ifade ediliyor. T\u00fcm\u00f6rlerin endotel h\u00fccrelerini nas\u0131l tahrip ettiklerinin anla\u015f\u0131lmas\u0131, tedaviye y\u00f6nelik ila\u00e7lar\u0131n geli\u015ftirilmesinde de \u00f6n a\u00e7\u0131c\u0131 olacak.<\/p>\n

\u00c7al\u0131\u015fmaya ili\u015fkin a\u00e7\u0131klamalar\u0131n\u0131 s\u00fcrd\u00fcren Saxe, \u201cBu konu hakk\u0131ndaki heyecan verici k\u0131s\u0131mlardan biri, engellemek durumunda oldu\u011fumuz molek\u00fcllere dair bilgi edinmi\u015f olmam\u0131z. ALK7’nin aktivitesini engelleyen ila\u00e7larla ilgili klinik deneyler de s\u00fcrmektedir. Dolay\u0131s\u0131yla, pankreas kanseri s\u00f6z konusu oldu\u011funda yeni bulgular\u0131n etkisini ilerleyen d\u00f6nemlerde daha net bir bi\u00e7imde g\u00f6rece\u011fiz\u201d dedi.<\/p>\n

Kaynak:<\/strong> https:\/\/www.sciencenews.org\/article\/pancreatic-cancer-tumors-attack-the-blood-vessels-that-deliver-chemo-drugs<\/p>\n","protected":false},"excerpt":{"rendered":"

Pankreas kanserinin tedavisi olduk\u00e7a zor bir kanser t\u00fcr\u00fc oldu\u011fu bilinir. Yeni ara\u015ft\u0131rmaya g\u00f6re bu durumun temel nedeni, pankreatik kanser h\u00fccrelerinin kan damarlar\u0131n\u0131 tahrip etmesidir. Kanser tedavisinde kullan\u0131lan ila\u00e7lar\u0131 hedef noktaya ula\u015ft\u0131racak olan kan damarlar\u0131n\u0131n tahrip edilmesi nedeniyle tedavi tam verim ile ger\u00e7ekle\u015ftirilemez. Yeni \u00e7al\u0131\u015fmayla elde edilen bilgilerle ilerleyen ara\u015ft\u0131rmac\u0131lar, t\u00fcm\u00f6r h\u00fccrelerinin kan damarlar\u0131n\u0131 nas\u0131l tahrip […]<\/p>\n","protected":false},"author":1390,"featured_media":36728,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[5301,444,5193,1171,2660],"class_list":["post-36727","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-kan-damari","tag-kanser","tag-pankreas","tag-protein","tag-tumor"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t