Vanderbilt \u00dcniversitesi ara\u015ft\u0131rmac\u0131lar\u0131n\u0131n ge\u00e7ti\u011fimiz hafta Cell Reports dergisinde yay\u0131mlad\u0131\u011f\u0131 \u00e7al\u0131\u015fmaya g\u00f6re, zarar g\u00f6rm\u00fc\u015f insan retinas\u0131n\u0131n onar\u0131lmas\u0131n\u0131n s\u0131rr\u0131 k\u00fc\u00e7\u00fck zebra bal\u0131klar\u0131nda sakl\u0131 olabilir.<\/p>\n
Halihaz\u0131rda 55 ya\u015f \u00fczerindeki milyonlarca Amerikal\u0131n\u0131n k\u00f6r olmas\u0131n\u0131n en yayg\u0131n sebebi olan ya\u015fa ba\u011fl\u0131 makula dejenerasyonu gibi retinal dejeneratif hastal\u0131klar\u0131n tedavisi i\u00e7in kullan\u0131lan birka\u00e7 etkili y\u00f6ntem var. Tavuk karas\u0131 rahats\u0131zl\u0131\u011f\u0131na sahip 100.000 Amerikal\u0131 i\u00e7in \u00f6ng\u00f6r\u00fclen sonu\u00e7 da ayn\u0131 \u015fekilde k\u00f6rl\u00fck. Bir\u00e7ok insan 40 ya\u015f\u0131na gelmeden yasal olarak k\u00f6r oluyor. Memeliler, bir hastal\u0131k sonucunda zarar g\u00f6rm\u00fc\u015f veya kaybolmu\u015f retinal n\u00f6ronlar\u0131 kendili\u011finden yenileyemezler. Ancak, bir\u00e7ok biyolojik ve medikal ara\u015ft\u0131rmada kullan\u0131lan iki bu\u00e7uk santimetre uzunlu\u011fundaki zebra bal\u0131klar\u0131 gibi kemikli bal\u0131klarda meydana gelen retinal hasar, retinal yap\u0131 ve fonksiyonunu geri getiren spontane bir yenilenme tepkisini tetikliyor.<\/p>\n
Bal\u0131ktan insana b\u00fct\u00fcn omurgal\u0131 hayvanlarda retina yap\u0131s\u0131 ve h\u00fccreleri olduk\u00e7a korundu\u011fu i\u00e7in, zebra bal\u0131klar\u0131n\u0131n zarar g\u00f6rm\u00fc\u015f retinalar\u0131n\u0131 nas\u0131l onard\u0131\u011f\u0131n\u0131 anlamak insanlarda kullan\u0131lan retinal yenileme y\u00f6ntemlerinin iyile\u015ftirilmesi i\u00e7in yeni yollara rehberlik edebilir. Vanderbilt \u00dcniversitesi Biyolojik Bilimler b\u00f6l\u00fcm\u00fcnde \u00f6\u011fretim g\u00f6revlisi Dr. James Patton ve i\u015f arkada\u015flar\u0131na g\u00f6re ke\u015ffedilen bir temel etken miR-216a olarak bilinen ve gen anlat\u0131m\u0131na dahil olan Dot1I enziminin anlat\u0131m\u0131n\u0131 d\u00fczenleyen bir mikro-RNA. \u00c7al\u0131\u015fma sonu\u00e7lar\u0131na g\u00f6re, miR-216a y\u0131 bask\u0131lamak, k\u0131smen Dot1I sal\u0131n\u0131m\u0131n\u0131n engellenmesiyle, zebra bal\u0131klar\u0131nda yenilenmi\u015f n\u00f6ronlar\u0131n kayna\u011f\u0131 olan M\u00fcller ba\u011f dokusunda (MBD) bir ba\u015fkala\u015f\u0131m ve \u00e7o\u011falma ba\u015flat\u0131yor. Bir sonraki ad\u0131m, miR-216a y\u0131 bask\u0131laman\u0131n memelilerdeki MBDda bir yeniden programlanma ve \u00e7o\u011falma ba\u015flat\u0131p ba\u015flatmayaca\u011f\u0131n\u0131 test etmek olacak.<\/p>\n
Vanderbilt \u00dcniversitesi Biyolojik Bilimler b\u00f6l\u00fcm\u00fcnde \u00e7al\u0131\u015fma y\u00fcr\u00fcten profes\u00f6r Patton, \u201cZebra bal\u0131klar\u0131n\u0131n retinas\u0131ndaki M\u00fcller ba\u011f dokusu, bir yeti\u015fkin k\u00f6k h\u00fccre olu\u015fturuyor ve bizim hedefimiz insan retinas\u0131nda benzer davran\u0131\u015fa sebebiyet veren, aktive edilebilecek metabolik yollar ve genleri tespit edebilmek\u201d a\u00e7\u0131klamalar\u0131nda bulunuyor.<\/p>\n
Kaynak:<\/strong> https:\/\/medicalxpress.com\/news\/2019-09-zebrafish-aid-effort-regenerate-retinas.html<\/p>\n","protected":false},"excerpt":{"rendered":" Vanderbilt \u00dcniversitesi ara\u015ft\u0131rmac\u0131lar\u0131n\u0131n ge\u00e7ti\u011fimiz hafta Cell Reports dergisinde yay\u0131mlad\u0131\u011f\u0131 \u00e7al\u0131\u015fmaya g\u00f6re, zarar g\u00f6rm\u00fc\u015f insan retinas\u0131n\u0131n onar\u0131lmas\u0131n\u0131n s\u0131rr\u0131 k\u00fc\u00e7\u00fck zebra bal\u0131klar\u0131nda sakl\u0131 olabilir. Halihaz\u0131rda 55 ya\u015f \u00fczerindeki milyonlarca Amerikal\u0131n\u0131n k\u00f6r olmas\u0131n\u0131n en yayg\u0131n sebebi olan ya\u015fa ba\u011fl\u0131 makula dejenerasyonu gibi retinal dejeneratif hastal\u0131klar\u0131n tedavisi i\u00e7in kullan\u0131lan birka\u00e7 etkili y\u00f6ntem var. Tavuk karas\u0131 rahats\u0131zl\u0131\u011f\u0131na sahip 100.000 Amerikal\u0131 […]<\/p>\n","protected":false},"author":1428,"featured_media":36985,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[623,788,5331,3204],"class_list":["post-36979","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-korluk","tag-retina","tag-zarar","tag-zebra-baligi"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t