\u0130nsan \u00f6l\u00fcmlerinin ba\u015fl\u0131ca nedeni konumunda bulunan kalp hastal\u0131klar\u0131, \u00e7e\u015fitli mekanizmalardaki bozukluklar nedeniyle g\u00f6zlenebilir. Bu alana ili\u015fkin yeni \u00e7al\u0131\u015fmada biliminsanlar\u0131, kalp hastal\u0131klar\u0131n\u0131n h\u00fccrenin enerji santrali olan mitokondrilerle ba\u011f\u0131na odakland\u0131.<\/p>\n
\u00d6nceki \u00e7al\u0131\u015fmalarda, ANT proteinini kodlayan gende g\u00f6r\u00fclen bozulmalar\u0131n kalp hastal\u0131\u011f\u0131 ve g\u00f6z kaslar\u0131nda zay\u0131fl\u0131k gibi durumlara neden oldu\u011fu ortaya \u00e7\u0131kar\u0131lm\u0131\u015ft\u0131. Bu hastal\u0131klar\u0131 ANT proteini ile ili\u015fkilendiren biliminsanlar\u0131, genlerde g\u00f6zlenen bozulman\u0131n hastal\u0131klar\u0131 nas\u0131l tetikledi\u011fine yan\u0131t aramak i\u00e7in yeni ara\u015ft\u0131rmalar ba\u015flatt\u0131. Pensilvanya \u00dcniversitesi\u2019nden ara\u015ft\u0131rmac\u0131lar, bu proteinin zarar g\u00f6rm\u00fc\u015f mitokondrilerin iyile\u015ftirilmesinde i\u015f g\u00f6rd\u00fc\u011f\u00fcn\u00fc ortaya \u00e7\u0131kard\u0131. Biliminsanlar\u0131 bu proteinin \u00fcretilmesinden sorumlu gende g\u00f6zlenen mutasyonlar\u0131n bu proteinin \u00fcretilmemesine yol a\u00e7t\u0131\u011f\u0131n\u0131, proteinin mitokondrilerin onar\u0131m\u0131nda i\u015flev g\u00f6rememesinin de kalp hastal\u0131klar\u0131na etki etti\u011fini raporlad\u0131lar.<\/p>\n
Nature dergisinde yay\u0131mlanan \u00e7al\u0131\u015fma \u00e7\u0131kt\u0131lar\u0131, kimyasal enerji \u00fcreten santraller konumundaki mitokondrilerin onar\u0131m\u0131 i\u00e7in \u00f6nemli olan bu proteinin yeni ve \u015fa\u015f\u0131rt\u0131c\u0131 i\u015flevini ortaya koymaktad\u0131r. \u00c7al\u0131\u015fma ekibinden Profes\u00f6r Zoltan Arany, \u201cANT proteinin \u00fcretilmesinden sorumlu genetik yap\u0131 \u00fczerindeki de\u011fi\u015fimlere odakland\u0131k. Bu \u00e7al\u0131\u015fma, hastal\u0131\u011fa neden olan mutasyonlara bak\u0131\u015f\u0131m\u0131z\u0131 de\u011fi\u015ftiriyor ve dikkatimizi do\u011fru noktaya odaklamam\u0131z\u0131 sa\u011fl\u0131yor\u201d dedi ve ekledi: \u201cArt\u0131k bu hastal\u0131klar\u0131n enerji \u00fcretme eksikli\u011finden ziyade hatal\u0131 onar\u0131mdan kaynakland\u0131\u011f\u0131n\u0131 biliyoruz. Bu durumun giderilmesini sa\u011flayacak tedavi yakla\u015f\u0131mlar\u0131 i\u00e7in \u00e7al\u0131\u015fabiliriz.\u201d<\/p>\n
H\u00fccrenin enerji merkezi olarak bilinen mitokondri, v\u00fccut i\u00e7in gereken enerjinin b\u00fcy\u00fck bir b\u00f6l\u00fcm\u00fcn\u00fc olu\u015fturur ve kalp, karaci\u011fer gibi y\u00fcksek enerjiye ihtiya\u00e7 duyan organlar i\u00e7in \u00f6nemli bir rol oynar. Hasar veya h\u00fccre i\u00e7i strese ba\u011fl\u0131 olarak mitokondrilerde g\u00f6zlenen bozulmalar, bu yap\u0131n\u0131n d\u00fczg\u00fcn \u00e7al\u0131\u015famamas\u0131n\u0131 sa\u011flar. CRISPR \/ Cas9 y\u00f6ntemini kullanan \u00e7al\u0131\u015fmac\u0131lar, \u00e7e\u015fitli h\u00fccre tiplerinde bu bozuklu\u011fun kayna\u011f\u0131na indi. Biliminsanlar\u0131 ANT proteinin \u00fcretilememesi durumunda, mitokondrilerin ATP \u00fcretmedeki rol\u00fcnden ba\u011f\u0131ms\u0131z olarak kalp hastal\u0131klar\u0131na yol a\u00e7t\u0131klar\u0131n\u0131 kaydetti.<\/p>\n
Kaynak:<\/strong> https:\/\/medicalxpress.com\/news\/2019-10-failure-mitochondrial-quality-heart-disease.html<\/p>\n","protected":false},"excerpt":{"rendered":" \u0130nsan \u00f6l\u00fcmlerinin ba\u015fl\u0131ca nedeni konumunda bulunan kalp hastal\u0131klar\u0131, \u00e7e\u015fitli mekanizmalardaki bozukluklar nedeniyle g\u00f6zlenebilir. Bu alana ili\u015fkin yeni \u00e7al\u0131\u015fmada biliminsanlar\u0131, kalp hastal\u0131klar\u0131n\u0131n h\u00fccrenin enerji santrali olan mitokondrilerle ba\u011f\u0131na odakland\u0131. \u00d6nceki \u00e7al\u0131\u015fmalarda, ANT proteinini kodlayan gende g\u00f6r\u00fclen bozulmalar\u0131n kalp hastal\u0131\u011f\u0131 ve g\u00f6z kaslar\u0131nda zay\u0131fl\u0131k gibi durumlara neden oldu\u011fu ortaya \u00e7\u0131kar\u0131lm\u0131\u015ft\u0131. Bu hastal\u0131klar\u0131 ANT proteini ile ili\u015fkilendiren biliminsanlar\u0131, […]<\/p>\n","protected":false},"author":1390,"featured_media":37582,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[281,306,5429,4006,1171],"class_list":["post-37581","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-enerji","tag-hucre","tag-kalp-hastaliklari","tag-mitokondri","tag-protein"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/37581","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1390"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=37581"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/37581\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media\/37582"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=37581"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=37581"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=37581"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}