Biliminsanlar\u0131 taraf\u0131ndan laboratuvarda geli\u015ftirilen “karaci\u011fer \u00e7ipi”, \u00e7e\u015fitli ila\u00e7lar\u0131n yan etkilerinin hayvan deneyleri yoluyla belirlenenden daha b\u00fcy\u00fck bir kesinlikle ortaya konulmas\u0131n\u0131 sa\u011flayacak.<\/p>\n
Science Translational Medicine portal\u0131nda, 6 Kas\u0131m g\u00fcn\u00fc yay\u0131mlanan rapora g\u00f6re biliminsanlar\u0131 bir “karaci\u011fer \u00e7ipi” \u00fcretti. Bir zar \u00fczerine yerle\u015ftirilen karaci\u011fer h\u00fccreleri, \u00e7e\u015fitli destekleyicilerle birlikte safra kanallar\u0131n\u0131 and\u0131ran yap\u0131lar kurdular. Birbirlerine benzer yap\u0131da olan s\u0131\u00e7an ve k\u00f6pek karaci\u011ferleri ile yap\u0131lan ilk deneylerde bu karaci\u011ferlerin ila\u00e7lara verdikleri tepkiler analiz edilerek, insan karaci\u011feri ile yap\u0131lan deneylerde ila\u00e7lara olan tepki ile kar\u015f\u0131la\u015ft\u0131rma yap\u0131lmas\u0131 sa\u011flanm\u0131\u015ft\u0131r. S\u0131\u00e7anlar, k\u00f6pekler ve di\u011fer pek \u00e7ok canl\u0131, insanlara verilmeden \u00f6nce ila\u00e7lar \u00fczerinde yap\u0131lan yan etki \u00e7al\u0131\u015fmalar\u0131nda s\u0131kl\u0131kla kullan\u0131l\u0131r. Ancak konuya ili\u015fkin ba\u015fka bir \u00e7al\u0131\u015fma, hayvanlar kullan\u0131larak yap\u0131lan testlerin do\u011fruluk oran\u0131n\u0131n y\u00fczde 71 oldu\u011funu ortaya koymu\u015ftu.<\/p>\n
Karaci\u011fer \u00e7ipi, deneylerde hayvanlar\u0131n yerine kullan\u0131larak bu deneyler yoluyla fark edilemeyecek yan etkilerin ortaya koyulmas\u0131 i\u00e7in tasarland\u0131. \u00d6rne\u011fin, y\u00fcksek tansiyon ilac\u0131 olarak kullan\u0131lan bir ila\u00e7 s\u0131\u00e7anlar\u0131n karaci\u011ferlerinde herhangi bir zarara neden olmaz ama insan karaci\u011ferinde safra tuzlar\u0131n\u0131n birikmesine neden olur. Ayr\u0131ca s\u0131\u00e7anlar ve k\u00f6pekler i\u00e7in zararl\u0131 olan baz\u0131 ila\u00e7lar, insanlara zarar vermeyebilir. \u0130nsan karaci\u011ferinden \u00fcretilen bu \u00e7ip kullan\u0131larak yap\u0131lan deneylerle, daha g\u00fcvenilir sonu\u00e7lara ula\u015f\u0131laca\u011f\u0131 d\u00fc\u015f\u00fcn\u00fclmekte.<\/p>\n
Kaynak:<\/strong> https:\/\/www.sciencenews.org\/article\/human-liver-chip-may-catch-drug-reactions-that-animal-testing-cant<\/p>\n","protected":false},"excerpt":{"rendered":" Biliminsanlar\u0131 taraf\u0131ndan laboratuvarda geli\u015ftirilen “karaci\u011fer \u00e7ipi”, \u00e7e\u015fitli ila\u00e7lar\u0131n yan etkilerinin hayvan deneyleri yoluyla belirlenenden daha b\u00fcy\u00fck bir kesinlikle ortaya konulmas\u0131n\u0131 sa\u011flayacak. Science Translational Medicine portal\u0131nda, 6 Kas\u0131m g\u00fcn\u00fc yay\u0131mlanan rapora g\u00f6re biliminsanlar\u0131 bir “karaci\u011fer \u00e7ipi” \u00fcretti. Bir zar \u00fczerine yerle\u015ftirilen karaci\u011fer h\u00fccreleri, \u00e7e\u015fitli destekleyicilerle birlikte safra kanallar\u0131n\u0131 and\u0131ran yap\u0131lar kurdular. Birbirlerine benzer yap\u0131da olan s\u0131\u00e7an […]<\/p>\n","protected":false},"author":1390,"featured_media":38170,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[5530,445,1946,5531],"class_list":["post-38169","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-cip","tag-ilac","tag-karaciger","tag-yan-etki"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/38169","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1390"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=38169"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/38169\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media\/38170"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=38169"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=38169"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=38169"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}