{"id":39095,"date":"2019-12-18T08:05:55","date_gmt":"2019-12-18T05:05:55","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=39095"},"modified":"2019-12-18T08:05:55","modified_gmt":"2019-12-18T05:05:55","slug":"tumor-olusumu-ile-iliskili-genler-evrimlesmede-etkili-mi","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2019\/12\/18\/tumor-olusumu-ile-iliskili-genler-evrimlesmede-etkili-mi","title":{"rendered":"T\u00fcm\u00f6r olu\u015fumu ile ili\u015fkili genler, evrimle\u015fmede etkili mi?"},"content":{"rendered":"

Rusya\u2019da bir \u00fcniversitede \u00e7al\u0131\u015fma y\u00fcr\u00fcten biliminsanlar\u0131, t\u00fcm\u00f6r olu\u015fumu ile ili\u015fkilendirilen genleri ara\u015ft\u0131rd\u0131. Scientific Reports\u2019ta yay\u0131nlanan yeni \u00e7al\u0131\u015fmada biliminsanlar\u0131 neoplazm olarak adland\u0131r\u0131lan yeni doku olu\u015fumunun evrimsel k\u00f6kenlerine odakland\u0131.<\/p>\n

Hastal\u0131k yap\u0131c\u0131 etkiye sahip yeni doku b\u00fcy\u00fcmeleri olan t\u00fcm\u00f6rler, genetik de\u011fi\u015fikler yoluyla h\u00fccrenin d\u00fczenleme ve denetim mekanizmas\u0131nda bozulmalar meydana getirir. B\u00f6ylelikle h\u00fccreler \u00e7e\u015fitli mekanizmalarda hata yapabilir hale gelir. Bu t\u00fcm\u00f6rler, iyi huylu veya k\u00f6t\u00fc huylu olabilmektedir. \u0130yi huylu t\u00fcm\u00f6rlerde k\u00f6t\u00fc huylu t\u00fcm\u00f6rlere k\u0131yasla daha yava\u015f bir b\u00fcy\u00fcme ve metastaz yapmama gibi durumlar g\u00f6zlenir. Bu t\u00fcrden t\u00fcm\u00f6r dokular\u0131n\u0131n bulunduklar\u0131 b\u00f6lgeden \u00e7\u0131kar\u0131lmas\u0131 daha kolayd\u0131r. Ancak k\u00f6t\u00fc huylu t\u00fcm\u00f6rler kanserle\u015fmeye neden olurlar. \u0130nsanlar\u0131n \u00f6l\u00fcm nedenlerine bak\u0131ld\u0131\u011f\u0131nda kanser hastal\u0131\u011f\u0131, kalp ve damar hastal\u0131klar\u0131n\u0131n ard\u0131ndan d\u00fcnya genelinde ikinci s\u0131rada gelmektedir.<\/p>\n

Biliminsanlar\u0131, t\u00fcm t\u00fcm\u00f6r dokular\u0131nda bulunan ve TSEEN genleri olarak adland\u0131rd\u0131klar\u0131 yeni bir gen s\u0131n\u0131f\u0131 ke\u015ffetti. \u00c7al\u0131\u015fmaya kat\u0131lan bir biliminsan\u0131 ara\u015ft\u0131rmaya ili\u015fkin a\u00e7\u0131klamalarda bulunarak \u201cBu genlerin evrimsel rol\u00fcne odaklan\u0131rsak, yeni ilerici \u00f6zelliklerin olu\u015fumuna katk\u0131 sa\u011flad\u0131klar\u0131n\u0131 g\u00f6rebiliriz. TSEEN genleri, neoplazm dokular\u0131nda \u00e7al\u0131\u015f\u0131r ve bu nedenle t\u00fcm\u00f6r belirteci olarak kullan\u0131labilirler\u201d dedi.<\/p>\n

Yeni ara\u015ft\u0131rma, daha \u00f6nce A. Kozlov taraf\u0131ndan ortaya koyulan bir yakla\u015f\u0131m\u0131 da do\u011fruluyor. Bu yakla\u015f\u0131ma g\u00f6re, insan v\u00fccudunda bulunan onkogen (t\u00fcm\u00f6rlerle ili\u015fkili genler) say\u0131s\u0131, ayn\u0131 canl\u0131 v\u00fccudunda bulunan farkl\u0131 h\u00fccre tiplerinin say\u0131s\u0131na kar\u015f\u0131l\u0131k gelmektedir. Ayr\u0131ca Kozlov\u2019un yakla\u015f\u0131m\u0131, onkogenlerin, t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 genlerin ve h\u00fccrelerde farkl\u0131la\u015fmalara neden olan genlerin evriminin ayn\u0131 anda ger\u00e7ekle\u015fti\u011fini ileri s\u00fcrm\u00fc\u015ft\u00fc. Bu yakla\u015f\u0131m, t\u00fcm\u00f6r\u00fcn i\u015flevsizle\u015fmesi yoluyla evrim hipotezine dayanmaktayd\u0131. Bu hipotez, t\u00fcm\u00f6rlerin \u00e7e\u015fitli i\u015flevleri yitirmeleri ile birlikte v\u00fccut i\u00e7erisinde yeni h\u00fccre tiplerinin, dokular\u0131n ve organlar\u0131n olu\u015fabilece\u011fini ve bu yolla evrimle\u015fme ger\u00e7ekle\u015febilece\u011fini ifade etmektedir.<\/p>\n

Bu yakla\u015f\u0131ma ili\u015fkin ilerletici bulgular edindiklerini ifade eden Kozlov, “\u00c7al\u0131\u015fmam\u0131z, kanser sorunu hen\u00fcz \u00e7\u00f6z\u00fclemedi\u011fi i\u00e7in b\u00fcy\u00fck bir \u00f6neme sahiptir. Teorimiz yeni \u00f6nleme ve tedavi stratejileri de \u00f6nerir” dedi.<\/p>\n

Kaynak:<\/strong> https:\/\/phys.org\/news\/2019-12-evolutionarily-genes-tumors.html<\/p>\n","protected":false},"excerpt":{"rendered":"

Rusya\u2019da bir \u00fcniversitede \u00e7al\u0131\u015fma y\u00fcr\u00fcten biliminsanlar\u0131, t\u00fcm\u00f6r olu\u015fumu ile ili\u015fkilendirilen genleri ara\u015ft\u0131rd\u0131. Scientific Reports\u2019ta yay\u0131nlanan yeni \u00e7al\u0131\u015fmada biliminsanlar\u0131 neoplazm olarak adland\u0131r\u0131lan yeni doku olu\u015fumunun evrimsel k\u00f6kenlerine odakland\u0131. Hastal\u0131k yap\u0131c\u0131 etkiye sahip yeni doku b\u00fcy\u00fcmeleri olan t\u00fcm\u00f6rler, genetik de\u011fi\u015fikler yoluyla h\u00fccrenin d\u00fczenleme ve denetim mekanizmas\u0131nda bozulmalar meydana getirir. B\u00f6ylelikle h\u00fccreler \u00e7e\u015fitli mekanizmalarda hata yapabilir hale gelir. […]<\/p>\n","protected":false},"author":1390,"featured_media":37266,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[200,431,444,2660],"class_list":["post-39095","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-evrim","tag-gen","tag-kanser","tag-tumor"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t