{"id":39471,"date":"2019-12-30T12:17:17","date_gmt":"2019-12-30T09:17:17","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=39471"},"modified":"2019-12-30T12:18:32","modified_gmt":"2019-12-30T09:18:32","slug":"hucre-bolunmesinde-etkin-olan-protein-kanser-tedavisi-icin-yeni-metotlar-sunabilir","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2019\/12\/30\/hucre-bolunmesinde-etkin-olan-protein-kanser-tedavisi-icin-yeni-metotlar-sunabilir","title":{"rendered":"H\u00fccre b\u00f6l\u00fcnmesinde etkin olan protein kanser tedavisi i\u00e7in yeni metotlar sunabilir"},"content":{"rendered":"

H\u00fccrelerin b\u00f6l\u00fcnerek yeni h\u00fccreleri olu\u015fturdu\u011fu s\u00fcre\u00e7te, h\u00fccrenin sahip oldu\u011fu genomun yeni h\u00fccrelere e\u015fit bir bi\u00e7imde da\u011f\u0131lmas\u0131 olduk\u00e7a b\u00fcy\u00fck bir \u00f6neme sahiptir. eLife isimli dergide yay\u0131mlanan \u00e7al\u0131\u015fma, Astrin ad\u0131 verilen proteinin h\u00fccre b\u00f6l\u00fcnmesi s\u0131ras\u0131nda kromozomlar\u0131n birbirlerinden ayr\u0131larak h\u00fccre i\u00e7erisindeki kutuplara \u00e7ekilmesinde olduk\u00e7a b\u00fcy\u00fck bir g\u00f6reve sahip oldu\u011funu ortaya \u00e7\u0131kard\u0131.<\/p>\n

H\u00fccre b\u00f6l\u00fcnmesi s\u0131ras\u0131nda h\u00fccrenin sahip oldu\u011fu genomun bir kopyas\u0131 \u00e7\u0131kar\u0131l\u0131r. Ard\u0131ndan bu kopya ile ana genetik materyal, h\u00fccre b\u00f6l\u00fcnmesi ile olu\u015facak olan yeni h\u00fccrelere e\u015fit bir bi\u00e7imde da\u011f\u0131t\u0131l\u0131r. Bu e\u015fit ayr\u0131m\u0131n sa\u011flanmas\u0131 i\u00e7in kromozomlar, mikroskobik yap\u0131da olan a\u011flarla h\u00fccre i\u00e7indeki kutuplara \u00e7ekilir. Bu durumun sorunsuz bir bi\u00e7imde ger\u00e7ekle\u015fmesi i\u00e7in kromozomlar\u0131n bu a\u011flara do\u011fru bir \u015fekilde ba\u011flanmas\u0131 gerekmektedir.<\/p>\n

Bununla birlikte, birbirlerinden ayr\u0131lan kromozomlar ile bu a\u011f aras\u0131ndaki ba\u011flant\u0131n\u0131n nas\u0131l korundu\u011fu biliminsanlar\u0131 taraf\u0131ndan ara\u015ft\u0131r\u0131lmaktayd\u0131. Yeni ara\u015ft\u0131rmada ise biliminsanlar\u0131, Astrin ad\u0131 verilen proteinin bu ba\u011f\u0131n do\u011fru bir bi\u00e7imde kurulmas\u0131n\u0131 sa\u011flad\u0131\u011f\u0131n\u0131 ortaya \u00e7\u0131kard\u0131. \u00c7al\u0131\u015fman\u0131n y\u00fcr\u00fct\u00fcc\u00fclerinden Profes\u00f6r Viji Draviam, \u201cAstin ile birlikte \u00e7al\u0131\u015fan enzimler, kromozomlar\u0131n a\u011flara ba\u011fland\u0131\u011f\u0131 b\u00f6lgelerin durumunu denetler ve DNA\u2019n\u0131n di\u011fer kuvvetlere kar\u015f\u0131 koyarak a\u011f taraf\u0131ndan h\u00fccre i\u00e7indeki kutup b\u00f6lgelerine \u00e7ekilmesini sa\u011flar. Bu protein sadece h\u00fccre b\u00f6l\u00fcnmesinin ilgili safhas\u0131na kadar herhangi bir sorun ya\u015fanmad\u0131ysa etkili olur. B\u00f6ylelikle h\u00fccrelerin do\u011fru say\u0131da kromozoma sahip olarak b\u00f6l\u00fcnmeleri sa\u011flan\u0131r\u201d a\u00e7\u0131klamalar\u0131nda bulundu.<\/p>\n

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Kromozomlar\u0131n ayr\u0131lmas\u0131 s\u0131ras\u0131nda \u00e7al\u0131\u015fan Astrin proteini.<\/figcaption><\/figure>\n

Evrimsel biyologlar\u0131n da kat\u0131l\u0131mc\u0131lar\u0131 aras\u0131nda oldu\u011fu \u00e7al\u0131\u015fmada Astrin ve ilgili enzimlerin birbirleriyle olan etkile\u015fimine de odaklan\u0131ld\u0131. Astrin proteinin etkili oldu\u011fu mekanizman\u0131n anla\u015f\u0131lmas\u0131, kanserle\u015fmede etkili olan kontrols\u00fcz h\u00fccre b\u00f6l\u00fcnmelerinin ve kromozom say\u0131lar\u0131nda do\u011fru da\u011f\u0131l\u0131mlar\u0131n olmad\u0131\u011f\u0131 h\u00fccrelerin nas\u0131l olu\u015ftu\u011funun anla\u015f\u0131lmas\u0131 a\u00e7\u0131s\u0131ndan olduk\u00e7a \u00f6nemli bir noktada. Biliminsanlar\u0131, bu konuya dair mevcut bilgilerimizin geli\u015fmesiyle birlikte yeni tedavi metotlar\u0131n\u0131n olu\u015fturulabilece\u011fini ifade ediyorlar. \u00c7al\u0131\u015fmada yer alan biliminsanlar\u0131ndan Profes\u00f6r Richard Pickersgill, \u201cH\u00fccrelerimiz, ya\u015fland\u0131\u011f\u0131nda veya hasar ald\u0131\u011f\u0131ndan b\u00f6l\u00fcnme durumuna ge\u00e7erler. B\u00f6ylelikle yeni h\u00fccrelerin \u00fcretimi ger\u00e7ekle\u015fir. H\u00fccre b\u00f6l\u00fcnmesi s\u0131ras\u0131nda kromozomlar\u0131n birbirlerinden ayr\u0131lmas\u0131 i\u00e7in i\u015flev g\u00f6ren 100\u2019den fazla protein bulunmaktad\u0131r. Bu \u00e7al\u0131\u015fma Astin proteininin h\u00fccre b\u00f6l\u00fcnmesi a\u00e7\u0131s\u0131ndan \u00f6nemini ortaya koyuyor ancak kromozom ayr\u0131lmalar\u0131n\u0131n ayr\u0131nt\u0131l\u0131 mekanizmas\u0131 a\u00e7\u0131s\u0131ndan ke\u015ffetmemiz gereken \u00e7ok \u015fey var\u201d dedi.<\/p>\n

Dr. Emily Armstrong ise kromozomlar\u0131n birbirlerinden ayr\u0131lmas\u0131 s\u0131ras\u0131nda meydana gelen s\u00fcreci anlaman\u0131n hayati \u00f6nem ta\u015f\u0131d\u0131\u011f\u0131n\u0131 belirterek, \u201cBu olaylar zincirindeki hatalar, kanser ve benzeri hastal\u0131klar\u0131n olu\u015fumuna neden olabilir. Bu ve benzeri \u00e7al\u0131\u015fmalar, \u00f6zellikle de kanserle\u015fmede etkili olan s\u00fcrecin anla\u015f\u0131lmas\u0131na neden olacak\u201d a\u00e7\u0131klamalar\u0131nda bulundu.<\/p>\n

Kaynak:<\/strong> https:\/\/phys.org\/news\/2019-12-insight-cells-dna.html<\/p>\n","protected":false},"excerpt":{"rendered":"

H\u00fccrelerin b\u00f6l\u00fcnerek yeni h\u00fccreleri olu\u015fturdu\u011fu s\u00fcre\u00e7te, h\u00fccrenin sahip oldu\u011fu genomun yeni h\u00fccrelere e\u015fit bir bi\u00e7imde da\u011f\u0131lmas\u0131 olduk\u00e7a b\u00fcy\u00fck bir \u00f6neme sahiptir. eLife isimli dergide yay\u0131mlanan \u00e7al\u0131\u015fma, Astrin ad\u0131 verilen proteinin h\u00fccre b\u00f6l\u00fcnmesi s\u0131ras\u0131nda kromozomlar\u0131n birbirlerinden ayr\u0131larak h\u00fccre i\u00e7erisindeki kutuplara \u00e7ekilmesinde olduk\u00e7a b\u00fcy\u00fck bir g\u00f6reve sahip oldu\u011funu ortaya \u00e7\u0131kard\u0131. H\u00fccre b\u00f6l\u00fcnmesi s\u0131ras\u0131nda h\u00fccrenin sahip oldu\u011fu genomun […]<\/p>\n","protected":false},"author":1390,"featured_media":39473,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[5720,5350,444,525,1171],"class_list":["post-39471","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-astrin","tag-hucre-bolunmesi","tag-kanser","tag-kromozom","tag-protein"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t