Los Alamos Ulusal Laboratuvar\u0131’nda \u00e7al\u0131\u015fma y\u00fcr\u00fcten biliminsanlar\u0131, k\u00f6k h\u00fccrelerin olu\u015fturulabilmesi i\u00e7in kritik \u00f6neme sahip olan ve genomun \u201ckaranl\u0131k maddesi\u201d olarak nitelendirilen bir RNA molek\u00fcl\u00fcn\u00fcn \u00fc\u00e7 boyutlu g\u00f6r\u00fcnt\u00fcs\u00fcn\u00fc elde etti.<\/p>\n
\u00c7al\u0131\u015fmaya kat\u0131lan biliminsanlar\u0131ndan Karissa Sanbonmatsu, \u201cBildi\u011fimiz kadar\u0131yla bu \u00e7al\u0131\u015fma, kodlanmayan yani protein yap\u0131m\u0131nda i\u015flev sahibi olmayan uzun zincir yap\u0131ndaki RNA’lara (IncRNA) ili\u015fkin ilk \u00fc\u00e7 boyutlu analiz \u00e7al\u0131\u015fmas\u0131d\u0131r. Bu analiz \u00e7al\u0131\u015fmas\u0131yla birlikte \u00f6zellikle kardiyovaskil\u00fcr bir bozukluk veya ya\u015flanmaya ba\u011fl\u0131 kalp rahats\u0131zl\u0131klar\u0131 i\u00e7in yeni tedavi metotlar\u0131 geli\u015ftirilebilir\u201d dedi.<\/p>\n
Nature Commications dergisinde yay\u0131mlanan \u00e7al\u0131\u015fmada yer alan biliminsanlar\u0131, ara\u015ft\u0131rmada RNA molek\u00fcl\u00fcn\u00fcn \u00fc\u00e7 boyutlu yap\u0131s\u0131n\u0131 elde edebilmek i\u00e7in bir t\u00fcr X-\u0131\u015f\u0131n\u0131 analizi olan SAXS tekni\u011fini kulland\u0131lar.<\/p>\n
2000 y\u0131l\u0131nda ger\u00e7ekle\u015ftirilen insan genomu dizileme \u00e7al\u0131\u015fmalar\u0131ndan \u00f6nce biliminsanlar\u0131, protein gibi yap\u0131lar\u0131n \u00fcretilmesinde b\u00fct\u00fcn genetik materyalin i\u015flev sahibi oldu\u011funu d\u00fc\u015f\u00fcn\u00fcrlerdi. Ancak dizileme \u00e7al\u0131\u015fmalar\u0131 s\u0131ras\u0131nda, genetik materyalin sadece y\u00fczde 10’luk b\u00f6l\u00fcm\u00fcn\u00fcn protein kodlad\u0131\u011f\u0131 ke\u015ffedildi. O zamandan beri genetik materyalimizin y\u00fczde 90’l\u0131k k\u0131sm\u0131n\u0131n i\u015flevsiz oldu\u011fu san\u0131lmaktayd\u0131. Ancak yap\u0131lan \u00e7al\u0131\u015fmalar bu b\u00f6lgelerin protein yap\u0131m\u0131nda i\u015flev sahibi olmayan RNA yap\u0131lar\u0131n\u0131 \u00fcrettiklerini g\u00f6sterdi. IncRNA ad\u0131 verilen bu RNA’lar\u0131n, h\u00fccre b\u00f6l\u00fcnmesi s\u0131ras\u0131nda genlerin a\u00e7\u0131l\u0131p kapand\u0131klar\u0131 evrelerde i\u015flev sahibi oldu\u011fu raporland\u0131. Bu molek\u00fcllerin bulunmad\u0131\u011f\u0131 ya da hasarl\u0131 oldu\u011fu bireylerde otizm, kanser hastal\u0131klar\u0131n\u0131n ve \u00e7e\u015fitli do\u011fum kusurlar\u0131n\u0131n g\u00f6zlendi\u011fi de ortaya \u00e7\u0131kar\u0131ld\u0131.<\/p>\n
Bu RNA tipinin k\u00f6k h\u00fccre \u00e7al\u0131\u015fmalar\u0131 a\u00e7\u0131s\u0131ndan \u00f6nemini vurgulayan biliminsanlar\u0131, bu molek\u00fcl\u00fcn yap\u0131s\u0131na ili\u015fkin kapsaml\u0131 \u00e7al\u0131\u015fmalar\u0131yla molek\u00fcl\u00fcn \u00fc\u00e7 boyutlu g\u00f6r\u00fcnt\u00fcs\u00fcn\u00fc elde etti. Bu \u00e7al\u0131\u015fman\u0131n, gen kontrol\u00fcnde etkin olan mekanizmalar\u0131n anla\u015f\u0131lmas\u0131 i\u00e7in yeni \u00e7al\u0131\u015fmalara kap\u0131 a\u00e7aca\u011f\u0131 d\u00fc\u015f\u00fcn\u00fclmekte.<\/p>\n
Kaynak:<\/strong> https:\/\/phys.org\/news\/2020-01-scientists-image-heart-rna.html<\/p>\n","protected":false},"excerpt":{"rendered":" Los Alamos Ulusal Laboratuvar\u0131’nda \u00e7al\u0131\u015fma y\u00fcr\u00fcten biliminsanlar\u0131, k\u00f6k h\u00fccrelerin olu\u015fturulabilmesi i\u00e7in kritik \u00f6neme sahip olan ve genomun \u201ckaranl\u0131k maddesi\u201d olarak nitelendirilen bir RNA molek\u00fcl\u00fcn\u00fcn \u00fc\u00e7 boyutlu g\u00f6r\u00fcnt\u00fcs\u00fcn\u00fc elde etti. \u00c7al\u0131\u015fmaya kat\u0131lan biliminsanlar\u0131ndan Karissa Sanbonmatsu, \u201cBildi\u011fimiz kadar\u0131yla bu \u00e7al\u0131\u015fma, kodlanmayan yani protein yap\u0131m\u0131nda i\u015flev sahibi olmayan uzun zincir yap\u0131ndaki RNA’lara (IncRNA) ili\u015fkin ilk \u00fc\u00e7 boyutlu analiz […]<\/p>\n","protected":false},"author":1390,"featured_media":39703,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[5746,272,773,2055,5745],"class_list":["post-39702","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-dizileme","tag-dna","tag-genom","tag-rna","tag-uc-boyut"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t