Ba\u011f\u0131\u015f\u0131k sistemimiz v\u00fccutta kansere d\u00f6n\u00fc\u015febilen h\u00fccrelere kar\u015f\u0131 m\u00fccadelede olduk\u00e7a \u00f6nemli bir noktadad\u0131r. Ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin bile\u015fenleri, h\u00fccrelerdeki de\u011fi\u015fimi fark eder ve bu h\u00fccreler i\u00e7in bir y\u0131k\u0131m program\u0131 ba\u015flat\u0131r. Kanser h\u00fccreleri mutasyona u\u011fray\u0131p ba\u011f\u0131\u015f\u0131kl\u0131k sistemi taraf\u0131ndan fark edilmedik\u00e7e bu y\u0131k\u0131m program\u0131ndan ka\u00e7abilir. Kanser h\u00fccreleri y\u0131k\u0131mdan ka\u00e7mak i\u00e7in bir t\u00fcr kamuflaj geli\u015ftirir.<\/p>\n
Freiburg \u00dcniversitesi ve Leibniz \u00dcniversitesi’nden ara\u015ft\u0131rmac\u0131lar kanser h\u00fccrelerinin kamujlaf geli\u015ftirmesine odakland\u0131 ve ba\u011f\u0131\u015f\u0131kl\u0131k sisteminden ka\u00e7makta etkili olan kamujlaf\u0131 sa\u011flayan bir protein oldu\u011funu a\u00e7\u0131klad\u0131. Bu proteinin nas\u0131l aktifle\u015fti\u011fi ve \u00e7al\u0131\u015fma mekanizmas\u0131 hakk\u0131nda ara\u015ft\u0131rma yapan biliminsanlar\u0131, proteinin \u00e7al\u0131\u015fma mekanizmas\u0131ndan yola \u00e7\u0131karak \u00e7e\u015fitli ila\u00e7lar geli\u015ftirilebilece\u011fini d\u00fc\u015f\u00fcn\u00fcyor.<\/p>\n
Science Advances portal\u0131nda yay\u0131nlanan \u00e7al\u0131\u015fmada ba\u011f\u0131\u015f\u0131kl\u0131k sistemimizin \u00e7al\u0131\u015fma mekanizmas\u0131 \u00fczerinde duruldu.<\/p>\n
Ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin en \u00f6nemli h\u00fccrelerinden biri olan T h\u00fccrelerinin \u00fczerinde “kontrol noktas\u0131 inhibit\u00f6rleri” ad\u0131 verilen proteinler vard\u0131r. Bu proteinler ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin aktifle\u015fmesi i\u00e7in gereken sinyalleri fark eder. Bu d\u00fczenleyici mekanizma yoluyla v\u00fccutta g\u00f6zlenen ate\u015f, k\u0131zar\u0131kl\u0131k gibi enfeksiyon belirtilerinin kontrolden \u00e7\u0131kmas\u0131 \u00f6nlenir.<\/p>\n
Kanser h\u00fccreleri, kontrols\u00fcz bir bi\u00e7imde \u00e7o\u011fal\u0131rken v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k mekanizmas\u0131ndan ka\u00e7mak i\u00e7in bu inflamasyon (ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin savunma yan\u0131tlar\u0131) mekanizmalar\u0131ndan yararlan\u0131r, b\u00f6ylelikle kamufle olabilirler. Biliminsanlar\u0131 bu mekanizmada etkin olan proteinleri ve sinyal yolaklar\u0131n\u0131 inceleyerek kamuflaj\u0131n nas\u0131l sa\u011fland\u0131\u011f\u0131n\u0131 ortaya \u00e7\u0131kard\u0131.<\/p>\n
\u00c7al\u0131\u015fmadaki bir sonraki ad\u0131m\u0131n sinyal yolaklar\u0131n\u0131n kodunu \u00e7\u00f6zmek oldu\u011funu belirten ara\u015ft\u0131rmac\u0131lar, kanser tedavisinde yeni bir a\u015famaya ge\u00e7ilebilece\u011fini kaydediyor.<\/p>\n
Kaynak:<\/strong> https:\/\/medicalxpress.com\/news\/2020-01-immune-cancer-cells.html<\/p>\n","protected":false},"excerpt":{"rendered":" Ba\u011f\u0131\u015f\u0131k sistemimiz v\u00fccutta kansere d\u00f6n\u00fc\u015febilen h\u00fccrelere kar\u015f\u0131 m\u00fccadelede olduk\u00e7a \u00f6nemli bir noktadad\u0131r. Ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin bile\u015fenleri, h\u00fccrelerdeki de\u011fi\u015fimi fark eder ve bu h\u00fccreler i\u00e7in bir y\u0131k\u0131m program\u0131 ba\u015flat\u0131r. Kanser h\u00fccreleri mutasyona u\u011fray\u0131p ba\u011f\u0131\u015f\u0131kl\u0131k sistemi taraf\u0131ndan fark edilmedik\u00e7e bu y\u0131k\u0131m program\u0131ndan ka\u00e7abilir. Kanser h\u00fccreleri y\u0131k\u0131mdan ka\u00e7mak i\u00e7in bir t\u00fcr kamuflaj geli\u015ftirir. Freiburg \u00dcniversitesi ve Leibniz \u00dcniversitesi’nden ara\u015ft\u0131rmac\u0131lar […]<\/p>\n","protected":false},"author":1390,"featured_media":37266,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[1194,306,444,5191],"class_list":["post-40097","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-bagisiklik","tag-hucre","tag-kanser","tag-sinyal"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/40097","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1390"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=40097"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/40097\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media\/37266"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=40097"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=40097"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=40097"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}