{"id":40195,"date":"2020-02-09T19:08:37","date_gmt":"2020-02-09T16:08:37","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=40195"},"modified":"2020-02-09T19:09:30","modified_gmt":"2020-02-09T16:09:30","slug":"unutmanin-sinirsel-mekanizmalarina-yolculuk","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2020\/02\/09\/unutmanin-sinirsel-mekanizmalarina-yolculuk","title":{"rendered":"Unutman\u0131n sinirsel mekanizmalar\u0131na yolculuk…"},"content":{"rendered":"

Hat\u0131rlamak ya da unutmak… Hat\u0131rlamam\u0131z i\u00e7in g\u00fc\u00e7l\u00fc sinir a\u011flar\u0131 depolar\u0131na ihtiyac\u0131m\u0131z var, peki unutmak i\u00e7in?<\/p>\n

7 \u015eubat g\u00fcn\u00fc Science dergisinde yay\u0131nlanan \u00e7al\u0131\u015fmada yer alan Paul Frankland, beynin unutma i\u00e7in kulland\u0131\u011f\u0131 mekanizmaya ili\u015fkin yeni verilerin elde edildi\u011fini bildirdi. Asl\u0131nda bu durum ilk ba\u015fta kula\u011fa k\u00f6t\u00fc gelebilir ancak unutmak, hat\u0131rlamak kadar \u00f6nemlidir. Frankland, unutman\u0131n \u00f6nemini vurgulayarak “D\u00fcnya s\u00fcrekli de\u011fi\u015fiyor. \u0130ki ay \u00f6nceki kahvalt\u0131 \u00f6\u011f\u00fcn\u00fcn\u00fc hat\u0131rlamak gibi \u00f6nemsiz an\u0131lardan kurtulmak beynin daha yeni ve faydal\u0131 bilgiler toplamas\u0131na izin veriyor” a\u00e7\u0131klamalar\u0131nda bulundu.<\/p>\n

Beynin an\u0131lar\u0131 biriktirmesine ili\u015fkin s\u00fcre\u00e7ler h\u00e2l\u00e2 tart\u0131\u015fmal\u0131d\u0131r. Unutman\u0131n ger\u00e7ekle\u015fmesi i\u00e7in beyindeki sinyal iletiminde de\u011fi\u015fiklikler gerekir. Beyindeki hassas ba\u011flant\u0131lar\u0131n ortadan kalkmas\u0131 veya de\u011fi\u015fmesi gerekir. Yeni \u00e7al\u0131\u015fmada beyinde aktif olan mikroglia isimli ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerinin “Tam olarak bunu yap” sinyali ile sinyal a\u011flar\u0131n\u0131n d\u00fczeninde de\u011fi\u015fiklik yapt\u0131\u011f\u0131 ve gerekli olmayan verileri sinyal a\u011flar\u0131n\u0131n yok olmas\u0131yla birlikte sildi\u011fi raporland\u0131.<\/p>\n

\u00c7in’deki Zhejiang \u00dcniversitesi T\u0131p Fak\u00fcltesi’nde \u00e7al\u0131\u015fma y\u00fcr\u00fcten Yan Gu, microglia h\u00fccrelerinin sinyal iletiminde g\u00f6revli olan sinaps b\u00f6lgelerinin etkinli\u011fini ortadan kald\u0131rd\u0131\u011f\u0131n\u0131 belirterek “Mikroglialar\u0131n sinapslar\u0131 ortadan kald\u0131rarak unutmaya neden olup olmad\u0131\u011f\u0131n\u0131 merak etmeye ba\u015flad\u0131k” a\u00e7\u0131klamalar\u0131nda bulundu. Yap\u0131lan deneysel \u00e7al\u0131\u015fmalar\u0131n sonu\u00e7lar\u0131 mikroglialar\u0131n unutmada etkili oldu\u011funu ortaya koydu.<\/p>\n

\u00c7al\u0131\u015fma ayn\u0131 zamanda an\u0131lar\u0131m\u0131z\u0131n savunmas\u0131z durumda oldu\u011funa da i\u015faret ediyor. Yap\u0131lan deneysel \u00e7al\u0131\u015fmalar, daha az yeniden \u00e7a\u011fr\u0131lan (yeniden hat\u0131rlanan) an\u0131lar\u0131n silinmesinin daha kolay oldu\u011funu ortaya koydu. \u00c7\u00fcnk\u00fc bu an\u0131lar\u0131n sinyal mekanizmalar\u0131 g\u00f6rece daha g\u00fc\u00e7s\u00fczd\u00fcr. Ara\u015ft\u0131rmac\u0131lar, mikroglialar\u0131n beynin ba\u015fka b\u00f6lgelerinde de sinapslar \u00fczerinde etkili olup olmad\u0131\u011f\u0131n\u0131 hen\u00fcz bilmiyorlar. Ayr\u0131ca s\u00fcrekli bir bi\u00e7imde geri \u00e7a\u011fr\u0131lmayan (s\u00fcrekli hat\u0131rlanmayan) baz\u0131 an\u0131lar\u0131n neden silinmedi\u011fine ili\u015fkin net bir a\u00e7\u0131klaman\u0131n da olmad\u0131\u011f\u0131n\u0131 kaydeden biliminsanlar\u0131, bu b\u00f6lgelerdeki sinapslar\u0131n daha dayan\u0131kl\u0131 olmas\u0131 nedeniyle unutman\u0131n zorla\u015ft\u0131\u011f\u0131n\u0131 d\u00fc\u015f\u00fcn\u00fcyorlar.<\/p>\n

Kaynak:<\/strong> https:\/\/www.sciencenews.org\/article\/brain-microglia-memories-forgetting<\/p>\n","protected":false},"excerpt":{"rendered":"

Hat\u0131rlamak ya da unutmak… Hat\u0131rlamam\u0131z i\u00e7in g\u00fc\u00e7l\u00fc sinir a\u011flar\u0131 depolar\u0131na ihtiyac\u0131m\u0131z var, peki unutmak i\u00e7in? 7 \u015eubat g\u00fcn\u00fc Science dergisinde yay\u0131nlanan \u00e7al\u0131\u015fmada yer alan Paul Frankland, beynin unutma i\u00e7in kulland\u0131\u011f\u0131 mekanizmaya ili\u015fkin yeni verilerin elde edildi\u011fini bildirdi. Asl\u0131nda bu durum ilk ba\u015fta kula\u011fa k\u00f6t\u00fc gelebilir ancak unutmak, hat\u0131rlamak kadar \u00f6nemlidir. Frankland, unutman\u0131n \u00f6nemini vurgulayarak “D\u00fcnya […]<\/p>\n","protected":false},"author":1390,"featured_media":37422,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[1829,254,5819,5820,5818],"class_list":["post-40195","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-ani","tag-beyin","tag-hatirlama","tag-mikroglia","tag-unutma"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t