Ulusal Sa\u011fl\u0131k Enstit\u00fcleri\u2019nden biliminsanlar\u0131 taraf\u0131ndan y\u00fcr\u00fct\u00fclen yeni \u00e7al\u0131\u015fmaya g\u00f6re, bir d\u00f6nem salg\u0131n boyutuna ula\u015fan MERS hastal\u0131\u011f\u0131n\u0131n etmeni olan koronavir\u00fcs i\u00e7in bir antiviral ila\u00e7 geli\u015ftirildi. Asl\u0131nda bu ila\u00e7 hali haz\u0131rda \u00fcretimde ve baz\u0131 vir\u00fcs k\u00f6kenli hastal\u0131klar\u0131n tedavisi i\u00e7in kullan\u0131l\u0131yor. Remdesivir adl\u0131 bu ilac\u0131n, enfeksiyondan \u00f6nce uygulanmas\u0131 durumunda MERS hastal\u0131\u011f\u0131n\u0131 \u00f6nledi\u011fi, enfeksiyonun ard\u0131ndan uyguland\u0131\u011f\u0131nda ise hastalar\u0131 iyile\u015ftirdi\u011fi kaydedildi.<\/p>\n
Ulusal Sa\u011fl\u0131k Enstit\u00fcleri i\u00e7erisinde yer alan Ulusal Alerji ve Enfeksiyon Hastal\u0131klar\u0131 Enstit\u00fcs\u00fc\u2019nde yap\u0131lan yeni \u00e7al\u0131\u015fmada rhesus makak maymunlar\u0131 kullan\u0131ld\u0131. Remdesivir maddesi, daha \u00f6nceki deneylerde de vir\u00fcslere kar\u015f\u0131 koruma i\u00e7in kullan\u0131labilir bir madde olarak raporlanm\u0131\u015ft\u0131. Bu antiviral maddenin Ebola ve Nipah vir\u00fcsleri ile enfekte olmu\u015f maymunlar\u0131 etkin bir bi\u00e7imde tedavi etti\u011fi g\u00f6zlenmi\u015fti. Ayr\u0131ca Remdesivir insanlarda Ebola vir\u00fcs\u00fcn\u00fcn neden oldu\u011fu hastal\u0131\u011f\u0131n tedavisi i\u00e7in de ara\u015ft\u0131r\u0131lm\u0131\u015f bir maddedir.<\/p>\n
MERS-CoV (MERS koronavir\u00fcs\u00fc), ilk olarak \u00c7in\u2019in Wuhan kentinde tespit edilen ve 2020 y\u0131l\u0131n\u0131n ba\u015flang\u0131c\u0131ndan bu yana bir salg\u0131na d\u00f6n\u00fc\u015ferek halk sa\u011fl\u0131\u011f\u0131n\u0131 k\u00fcresel \u00f6l\u00e7ekte tehdit eden SARS-CoV-2 (Wuhan koronavir\u00fcs\u00fc) ile yak\u0131ndan ili\u015fkilidir.<\/p>\n
Ara\u015ft\u0131rmac\u0131lar, \u00e7al\u0131\u015fma i\u00e7in \u00fc\u00e7 adet deney grubu belirledi: MERS-CoV taraf\u0131ndan enfekte edilmeden 24 saat \u00f6nce Remdesivir uygulananlar, enfeksiyondan 12 saat sonra tedavi edilenler ve hastal\u0131\u011f\u0131n tedavi uygulanmadan nas\u0131l ilerledi\u011finin g\u00f6zlenebilmesi i\u00e7in kullan\u0131lan kontrol grubu. Biliminsanlar\u0131 alt\u0131 g\u00fcn boyunca bu canl\u0131lar \u00fczerinde g\u00f6zlem yapt\u0131. Kontrol i\u00e7in kullan\u0131lan hayvanlar MERS koronavir\u00fcs\u00fcn\u00fcn neden oldu\u011fu solunum yolu hastal\u0131klar\u0131n\u0131n belirtilerini g\u00f6sterdiler. Enfeksiyondan \u00f6nce Remdesivir uygulanan canl\u0131larda hastal\u0131k belirtisi yoktu. Kontrol grubundaki canl\u0131lara k\u0131yasla v\u00fccutlar\u0131 i\u00e7erisinde vir\u00fcs \u00e7o\u011falmas\u0131 s\u0131n\u0131rl\u0131yd\u0131 ve akci\u011fer hasar\u0131 yoktu. Enfeksiyonun ard\u0131ndan tedavi edilen hayvanlarda ise \u00f6nemli \u00f6l\u00e7\u00fcde iyile\u015fme g\u00f6zlenmi\u015ftir. Bu canl\u0131larda g\u00f6zlenen hastal\u0131k, kontrol hayvanlar\u0131nda g\u00f6zlenenden daha az \u015fiddetliydi. Dolay\u0131s\u0131yla akci\u011fer hasar\u0131 ve vir\u00fcs \u00e7o\u011falmas\u0131, kontrol grubuna k\u0131yasla daha azd\u0131.<\/p>\n
MERS-CoV ilk olarak 2012 y\u0131l\u0131nda Suudi Arabistan\u2019da ortaya \u00e7\u0131kt\u0131. Aral\u0131k 2019\u2019a kadar 2.499 enfeksiyon vakas\u0131 oldu\u011fu raporland\u0131. Bu enfeksiyon vakalar\u0131n\u0131n 861\u2019i ya\u015fam\u0131n\u0131 yitirdi. Remdesivir\u2019in hastal\u0131\u011f\u0131n tedavisinde kullan\u0131labilece\u011fi d\u00fc\u015f\u00fcn\u00fcl\u00fcyor. Biliminsanlar\u0131, \u00c7in\u2019in Wuhan kentinden yay\u0131lmaya ba\u015flayan SARS-CoV-2 salg\u0131n\u0131n\u0131n tedavisi i\u00e7in de Remdesivir\u2019in kullan\u0131labilece\u011fini kaydediyor. \u00c7in\u2019deki biliminsanlar\u0131n\u0131n Remdesivir\u2019in klinik testleri \u00fczerinde \u00e7al\u0131\u015ft\u0131klar\u0131 da ge\u00e7ti\u011fimiz g\u00fcnlerde a\u00e7\u0131klanm\u0131\u015ft\u0131.<\/p>\n
Kaynak:<\/strong> https:\/\/medicalxpress.com\/news\/2020-02-remdesivir-mers-coronavirus-disease-monkeys.html Ulusal Sa\u011fl\u0131k Enstit\u00fcleri\u2019nden biliminsanlar\u0131 taraf\u0131ndan y\u00fcr\u00fct\u00fclen yeni \u00e7al\u0131\u015fmaya g\u00f6re, bir d\u00f6nem salg\u0131n boyutuna ula\u015fan MERS hastal\u0131\u011f\u0131n\u0131n etmeni olan koronavir\u00fcs i\u00e7in bir antiviral ila\u00e7 geli\u015ftirildi. Asl\u0131nda bu ila\u00e7 hali haz\u0131rda \u00fcretimde ve baz\u0131 vir\u00fcs k\u00f6kenli hastal\u0131klar\u0131n tedavisi i\u00e7in kullan\u0131l\u0131yor. Remdesivir adl\u0131 bu ilac\u0131n, enfeksiyondan \u00f6nce uygulanmas\u0131 durumunda MERS hastal\u0131\u011f\u0131n\u0131 \u00f6nledi\u011fi, enfeksiyonun ard\u0131ndan uyguland\u0131\u011f\u0131nda ise hastalar\u0131 iyile\u015ftirdi\u011fi […]<\/p>\n","protected":false},"author":1390,"featured_media":40233,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[5763,5828,5829,5827,5762],"class_list":["post-40232","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-koronavirus","tag-mers-cov","tag-remdesivir","tag-sars-cov-2","tag-wuhan"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t
\nhttps:\/\/www.nih.gov\/news-events\/news-releases\/remdesivir-prevents-mers-coronavirus-disease-monkeys<\/p>\n","protected":false},"excerpt":{"rendered":"