{"id":40615,"date":"2020-03-10T10:21:02","date_gmt":"2020-03-10T07:21:02","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=40615"},"modified":"2020-03-10T12:51:16","modified_gmt":"2020-03-10T09:51:16","slug":"sars-cov-2-virusu-akciger-hucrelerine-nasil-baglanir","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2020\/03\/10\/sars-cov-2-virusu-akciger-hucrelerine-nasil-baglanir","title":{"rendered":"SARS-CoV-2 vir\u00fcs\u00fc akci\u011fer h\u00fccrelerine nas\u0131l ba\u011flan\u0131r?"},"content":{"rendered":"

Hangzhou \u00dcniversitesi, Westlake \u00dcniversitesi ve Tsinghua \u00dcniversitesi\u2019nden biliminsanlar\u0131, SARS-CoV-2 olarak adland\u0131r\u0131lan koronavir\u00fcs taraf\u0131ndan enfekte edilen bir insan h\u00fccresini enfeksiyonun ilk a\u015famalar\u0131nda izleyerek s\u00fcrecin y\u00fcksek \u00e7\u00f6z\u00fcn\u00fcrl\u00fckl\u00fc g\u00f6r\u00fcnt\u00fcs\u00fcn\u00fc elde etti. Science dergisinde yay\u0131nlanan makalelerinde ekip, g\u00f6r\u00fcnt\u00fcn\u00fcn nas\u0131l elde edildi\u011fini ve bize ne anlatt\u0131\u011f\u0131n\u0131 ifade ediyor.<\/p>\n

Mevcut salg\u0131n\u0131, D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fc taraf\u0131ndan COVID-19 olarak adland\u0131r\u0131lan salg\u0131n hastal\u0131\u011f\u0131n yay\u0131lmas\u0131 olarak tan\u0131ml\u0131yoruz. COVID-19 hastal\u0131\u011f\u0131na neden olan vir\u00fcs ise SARS-CoV-2 olarak adland\u0131r\u0131ld\u0131. Vir\u00fcs yay\u0131l\u0131m\u0131n\u0131 s\u00fcrd\u00fcr\u00fcrken, d\u00fcnyan\u0131n d\u00f6rt bir yan\u0131ndan biliminsanlar\u0131 da vir\u00fcse kar\u015f\u0131 bir a\u015f\u0131 geli\u015ftirmek i\u00e7in SARS-CoV-2 vir\u00fcs\u00fcn\u00fc daha iyi anlamaya \u00e7al\u0131\u015f\u0131yor. \u00c7in\u2019deki biliminsanlar\u0131 da bu ama\u00e7la \u00e7al\u0131\u015fmalar\u0131n\u0131 s\u00fcrd\u00fcr\u00fcyor. Konuya ili\u015fkin olarak \u00c7in\u2019de \u00e7al\u0131\u015fma y\u00fcr\u00fcten bir ekip, enfeksiyonun ilk a\u015famalar\u0131nda olan bir vir\u00fcs\u00fcn g\u00f6r\u00fcnt\u00fcs\u00fcn\u00fc elde etti. S\u00f6z konusu \u00e7al\u0131\u015fma, Austin\u2019de bulunan Teksas \u00dcniversitesi ve Ulusal Sa\u011fl\u0131k Enstit\u00fcleri\u2019nden (NIH) ara\u015ft\u0131rmac\u0131lar\u0131n yer ald\u0131\u011f\u0131 son \u00e7al\u0131\u015fmalardan birinden yola \u00e7\u0131k\u0131larak yap\u0131ld\u0131. Vir\u00fcs \u00fczerinde bulunan spike proteininin, insanlardaki ACE2 genine 2003\u2019teki SARS salg\u0131n\u0131nda hastal\u0131k etmeni olan vir\u00fcsten daha s\u0131k\u0131 ba\u011fland\u0131\u011f\u0131n\u0131 buldular.<\/p>\n

Spike proteini olarak adland\u0131r\u0131lan yap\u0131, vir\u00fcs\u00fcn konak\u00e7\u0131 olarak se\u00e7ilen h\u00fccreye eri\u015fiminin sa\u011flanmas\u0131 i\u00e7in \u201ckap\u0131y\u0131 a\u00e7an\u201d bir anahtar gibi i\u015fler. \u015eubat ay\u0131nda yay\u0131nlanan bir \u00e7al\u0131\u015fmada SARS-CoV-2 vir\u00fcs\u00fcn\u00fcn spike proteininin SARS vir\u00fcs\u00fcnden 10-20 kat daha y\u00fcksek ba\u011flanma g\u00fcc\u00fcne sahip oldu\u011fu belirtildi. Biliminsanlar\u0131 SARS-CoV-2\u2019nin (son salg\u0131n\u0131n etmeni olan vir\u00fcs), SARS\u2019tan (2003\u2019teki salg\u0131n\u0131n etmeni olan vir\u00fcs) \u00e7ok daha \u201cyap\u0131\u015fkan\u201d oldu\u011funu ifade ediyor.<\/p>\n

Vir\u00fcs\u00fcn ba\u011flanma mekanizmas\u0131na ili\u015fkin yeni bir \u00e7al\u0131\u015fmaya imza atan biliminsanlar\u0131, enfeksiyonun ilk a\u015famalar\u0131nda olan SARS-CoV-2 vir\u00fcs\u00fcn\u00fcn ACE2 genine ba\u011flanmas\u0131n\u0131 g\u00f6steren g\u00f6r\u00fcnt\u00fcleri yakalamak i\u00e7in kriyoelektron mikroskopisi metodunu kulland\u0131lar.<\/p>\n

\"\"<\/p>\n

ACE2 geni taraf\u0131ndan sentezlenen protein, antiyotensin ad\u0131 verilen bir hormonun aktif hale getirilmesinde g\u00f6revli olan bir enzimdir. Kalpte, ba\u011f\u0131rsaklarda, b\u00f6breklerde ve en \u00f6nemli \u00e7al\u0131\u015fma noktalar\u0131ndan biri olan akci\u011ferlerde i\u015flev g\u00f6r\u00fcr. Ge\u00e7mi\u015f d\u00f6nemlerde yap\u0131lan \u00e7al\u0131\u015fmalar ACE2 proteininin SARS vir\u00fcs\u00fc gibi pek \u00e7ok vir\u00fcs taraf\u0131ndan hedef al\u0131nd\u0131\u011f\u0131n\u0131 ortaya koymu\u015ftur. Ayr\u0131ca amino asitlerin h\u00fccre zar\u0131 boyunca ta\u015f\u0131nmas\u0131nda da i\u015f g\u00f6ren ACE2 enzimi, bu \u00f6nemli i\u015flevi nedeniyle viral enfeksiyonlarda hedef al\u0131nan molek\u00fcllerden biridir.<\/p>\n

SARS-CoV-2 vir\u00fcs\u00fcne ili\u015fkin yeni g\u00f6r\u00fcnt\u00fcler elde etmek isteyen biliminsanlar\u0131 \u00e7al\u0131\u015fmay\u0131 ba\u015flatmak i\u00e7in y\u00fcksek konsantrasyonlu ACE2 proteini, y\u00fcksek konsantrasyonlu ba\u015fka bir protein ve canl\u0131 vir\u00fcs i\u00e7eren bir \u00e7\u00f6zelti olu\u015fturdu. Ard\u0131ndan ara\u015ft\u0131rmac\u0131lar \u00f6rnekleri h\u0131zl\u0131 bir \u015fekilde dondurdu ve olu\u015fan yap\u0131y\u0131 incelemek i\u00e7in kriyoelektron mikroskopisini devreye soktu. \u00c7al\u0131\u015fman\u0131n sonucunda s\u00f6z konusu yap\u0131ya ili\u015fkin iki boyutlu \u00e7ok say\u0131da g\u00f6r\u00fcnt\u00fc elde edildi. Biliminsanlar\u0131 iki boyutlu g\u00f6r\u00fcnt\u00fcleri kullanarak vir\u00fcs\u00fcn ba\u011flanma mekanizmas\u0131na ili\u015fkin \u00fc\u00e7 boyutlu g\u00f6r\u00fcnt\u00fcleri elde etmi\u015f oldu.<\/p>\n

Kaynak:<\/strong> MEDICAL XPRESS<\/a>; SCIENCE<\/a>; NCBI<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Hangzhou \u00dcniversitesi, Westlake \u00dcniversitesi ve Tsinghua \u00dcniversitesi\u2019nden biliminsanlar\u0131, SARS-CoV-2 olarak adland\u0131r\u0131lan koronavir\u00fcs taraf\u0131ndan enfekte edilen bir insan h\u00fccresini enfeksiyonun ilk a\u015famalar\u0131nda izleyerek s\u00fcrecin y\u00fcksek \u00e7\u00f6z\u00fcn\u00fcrl\u00fckl\u00fc g\u00f6r\u00fcnt\u00fcs\u00fcn\u00fc elde etti. Science dergisinde yay\u0131nlanan makalelerinde ekip, g\u00f6r\u00fcnt\u00fcn\u00fcn nas\u0131l elde edildi\u011fini ve bize ne anlatt\u0131\u011f\u0131n\u0131 ifade ediyor. Mevcut salg\u0131n\u0131, D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fc taraf\u0131ndan COVID-19 olarak adland\u0131r\u0131lan salg\u0131n hastal\u0131\u011f\u0131n yay\u0131lmas\u0131 […]<\/p>\n","protected":false},"author":1390,"featured_media":40357,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[5543,5848,1875,5827,492],"class_list":["post-40615","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-akciger","tag-covid-19","tag-enfeksiyon","tag-sars-cov-2","tag-virus"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t