Minnesota \u00dcniversitesi’ndeki ara\u015ft\u0131rmac\u0131lar, koronavir\u00fcs\u00fcn h\u00fccrelere kilitlenmek i\u00e7in kulland\u0131\u011f\u0131 S proteininin \u00fc\u00e7 boyutlu haritas\u0131n\u0131 \u00e7\u0131kard\u0131lar.<\/p>\n
Yeni ara\u015ft\u0131rmalar, koronavir\u00fcs\u00fcn insanlar\u0131 enfekte edip d\u00fcnyaya h\u0131zla yay\u0131lmas\u0131n\u0131 sa\u011flayan \u00f6nemli bir biyolojik mekanizmaya \u0131\u015f\u0131k tuttu.<\/p>\n
Vir\u00fcs\u00fcn yap\u0131s\u0131yla ilgili detayl\u0131 bir analiz, koronavir\u00fcs\u00fcn insan h\u00fccrelerinde enfeksiyon olu\u015fturmak i\u00e7in kulland\u0131\u011f\u0131 tokma\u011fa benzeyen S proteinlerinin, 2002 y\u0131l\u0131nda y\u00fczlerce insan\u0131n \u00f6l\u00fcm\u00fcne sebep olan SARS koronavir\u00fcs\u00fcn\u00fcn S proteinleri ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda h\u00fccreye yakla\u015f\u0131k d\u00f6rt kat daha g\u00fc\u00e7l\u00fc tutundu\u011funu g\u00f6stermektedir.<\/p>\n
Ara\u015ft\u0131rma bulgular\u0131na g\u00f6re burun veya a\u011f\u0131z yoluyla teneff\u00fcs etti\u011fimiz vir\u00fcs par\u00e7ac\u0131klar\u0131n\u0131n \u00fcst solunum yolundaki h\u00fccrelere yap\u0131\u015fma riskleri y\u00fcksek, ki bu durum vir\u00fcs\u00fcn v\u00fccudumuzda yer edinmesi ihtimalinin hi\u00e7 de d\u00fc\u015f\u00fck olmad\u0131\u011f\u0131 anlam\u0131na geliyor.
\nMinnesota \u00dcniversitesi’nde \u00e7al\u0131\u015fan bilim insanlar\u0131, vir\u00fcs\u00fcn S proteininin ve ACE-2 resept\u00f6r\u00fc olarak bilinen insan h\u00fccreleri \u00fczerindeki ilgili orta\u011f\u0131n\u0131n atomik \u00f6l\u00e7ekte \u00fc\u00e7 boyutlu haritas\u0131n\u0131 olu\u015fturmak i\u00e7in X-\u0131\u015f\u0131n\u0131 kristallografisini kulland\u0131lar.<\/p>\n
Vir\u00fcs bir insan h\u00fccresiyle kar\u015f\u0131la\u015ft\u0131\u011f\u0131nda, konak h\u00fccre kabul ederse vir\u00fcs\u00fcn y\u00fczeyinde bulunan S proteinleri ACE-2 resept\u00f6rlerine yap\u0131\u015farak koronavir\u00fcs\u00fcn h\u00fccreye girip \u00e7o\u011falmas\u0131na olanak sa\u011fl\u0131yor.<\/p>\n
ABD ekibine liderlik eden Dr Fang Li, \u00fc\u00e7 boyutlu yap\u0131dan hareketle yeni koronavir\u00fcs\u00fcn, 2002-2003 y\u0131llar\u0131 aras\u0131nda SARS salg\u0131n\u0131na neden olan vir\u00fcse k\u0131yasla resept\u00f6rlere daha s\u0131k\u0131 ba\u011flanacak \u015fekilde evrimle\u015fti\u011fini ifade etti: \u201cResept\u00f6re s\u0131k\u0131 ba\u011flanma, vir\u00fcs\u00fcn insan h\u00fccrelerine bula\u015fmas\u0131na ve insanlar aras\u0131nda yay\u0131lmas\u0131na yard\u0131mc\u0131 olabilir.\u201d<\/p>\n
Vir\u00fcs haritas\u0131, vir\u00fcs\u00fcn \u00e7o\u011falmas\u0131 h\u0131zlanmadan ve enfeksiyon d\u00fcnyam\u0131z\u0131 ele ge\u00e7irmeden \u00f6nce onu etkisiz hale getirebilecek potansiyel ila\u00e7lar\u0131 aramak amac\u0131yla bilim insanlar\u0131nca kullan\u0131lacak. Li, \u201cYeni bir antikor ilac\u0131 vir\u00fcs \u00fczerindeki bu alanlara resept\u00f6rden daha g\u00fc\u00e7l\u00fc ve s\u0131k ba\u011flanabiliyorsa, vir\u00fcs\u00fcn h\u00fccrelere giri\u015fini bloke ederek viral enfeksiyonlar i\u00e7in potansiyel olarak etkili bir tedavi haline gelecektir\u201d dedi ve h\u00fccre \u00fczerindeki bu alanlar\u0131n, gelecekteki enfeksiyonlar\u0131 \u00f6nlemek amac\u0131yla a\u015f\u0131lar \u00fczerindeki \u00e7al\u0131\u015fmalar\u0131 \u015fekillendirmede de kullan\u0131labilece\u011fini ekledi.<\/p>\n
Nature dergisinde yazan ara\u015ft\u0131rmac\u0131lar, k\u00fcresel salg\u0131n\u0131n etmeni olan koronavir\u00fcs\u00fcn yap\u0131s\u0131n\u0131 yarasalarda ve pangolinlerde bulunan koronavir\u00fcs\u00fcn su\u015f dedi\u011fimiz genetik farkl\u0131l\u0131klara sahip alt t\u00fcrleriyle nas\u0131l kar\u015f\u0131la\u015ft\u0131rd\u0131klar\u0131n\u0131 a\u00e7\u0131klad\u0131lar. Ayn\u0131 zamanda her iki hayvan su\u015funun ayn\u0131 insan ACE-2 resept\u00f6r\u00fcne ba\u011flanabildi\u011fini, yani insan koronavir\u00fcs\u00fcn\u00fcn ya do\u011frudan ya da yarasalar taraf\u0131ndan enfekte olan pangolinlerden geldi\u011fini g\u00f6steren \u00f6nceki \u00e7al\u0131\u015fmalar\u0131 destekledi\u011fini ortaya \u00e7\u0131kard\u0131lar. Hayvan su\u015flar\u0131 insanlar\u0131 enfekte etmeden \u00f6nce vir\u00fcs\u00fcn insanlarda daha kolay yay\u0131lmas\u0131n\u0131 sa\u011flayan mutasyonlar ge\u00e7irmi\u015flerdi.<\/p>\n
Nottingham \u00dcniversitesi’nde viroloji profes\u00f6r\u00fc olan Jonathan Ball da, \u201cCovid-19’a neden olan koronavir\u00fcs SARS-CoV-2’nin, yak\u0131n akrabas\u0131 olan SARS’tan \u00e7ok farkl\u0131 davrand\u0131\u011f\u0131n\u0131 biliyoruz” dedi: \u201cSARS-Cov-2 \u00f6zellikle bo\u011faz\u0131 ve burnu etkili bir \u015fekilde enfekte ederek hafif so\u011fuk benzeri semptomlara neden olurken, SARS neredeyse her zaman akci\u011ferlerde \u00e7o\u011fal\u0131r.” \u00c7al\u0131\u015fma, bu fark\u0131n ilgi \u00e7ekici bir nedenini \u015f\u00f6yle sunmakta: SARS-CoV-2 vir\u00fcs\u00fcn\u00fcn y\u00fczeyinde yer alan S proteini, h\u00fccre i\u00e7in bir kap\u0131 g\u00f6revi g\u00f6ren ACE-2 ad\u0131 verilen resept\u00f6r\u00fcn h\u00fccre y\u00fczeyi proteinine daha etkili bir bi\u00e7imde ba\u011flanabiliyor. Bu geli\u015fmi\u015f ba\u011flanma ise vir\u00fcs\u00fcn burnu ve bo\u011faz\u0131 daha etkin olarak enfekte etmesine izin verebilir.<\/p>\n
Ball, bu \u00e7al\u0131\u015fmada sadece S proteinlerinin ve konak h\u00fccrenin ACE-2 proteinlerinin incelendi\u011fini s\u00f6zlerine ekledi. \u0130ncelemeler sonucunda ula\u015f\u0131lan bulgularla edinilenler ise yaln\u0131zca bir teori: “Kesin \u00e7\u0131kar\u0131mlar, daha ileri boyutta deneyler yap\u0131larak do\u011frulanmaya ihtiya\u00e7 duyacakt\u0131r.”<\/p>\n
Kaynak:<\/strong> https:\/\/www.theguardian.com\/world\/2020\/mar\/30\/new-study-sheds-light-on-coronavirus-infection-mechanism<\/p>\n","protected":false},"excerpt":{"rendered":" Minnesota \u00dcniversitesi’ndeki ara\u015ft\u0131rmac\u0131lar, koronavir\u00fcs\u00fcn h\u00fccrelere kilitlenmek i\u00e7in kulland\u0131\u011f\u0131 S proteininin \u00fc\u00e7 boyutlu haritas\u0131n\u0131 \u00e7\u0131kard\u0131lar. Yeni ara\u015ft\u0131rmalar, koronavir\u00fcs\u00fcn insanlar\u0131 enfekte edip d\u00fcnyaya h\u0131zla yay\u0131lmas\u0131n\u0131 sa\u011flayan \u00f6nemli bir biyolojik mekanizmaya \u0131\u015f\u0131k tuttu. Vir\u00fcs\u00fcn yap\u0131s\u0131yla ilgili detayl\u0131 bir analiz, koronavir\u00fcs\u00fcn insan h\u00fccrelerinde enfeksiyon olu\u015fturmak i\u00e7in kulland\u0131\u011f\u0131 tokma\u011fa benzeyen S proteinlerinin, 2002 y\u0131l\u0131nda y\u00fczlerce insan\u0131n \u00f6l\u00fcm\u00fcne sebep olan SARS […]<\/p>\n","protected":false},"author":1248,"featured_media":40071,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[5925,5848,5763,5850,5827],"class_list":["post-41046","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-ace2","tag-covid-19","tag-koronavirus","tag-sars","tag-sars-cov-2"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/41046","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1248"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=41046"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/41046\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media\/40071"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=41046"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=41046"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=41046"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}