{"id":41578,"date":"2020-04-04T15:11:41","date_gmt":"2020-04-04T12:11:41","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=41578"},"modified":"2020-04-04T15:12:12","modified_gmt":"2020-04-04T12:12:12","slug":"koronavirusun-hucrelere-baglanmasinda-etkili-olan-proteinin-yapay-formu-hastaligi-engelleyebilir-mi","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2020\/04\/04\/koronavirusun-hucrelere-baglanmasinda-etkili-olan-proteinin-yapay-formu-hastaligi-engelleyebilir-mi","title":{"rendered":"Koronavir\u00fcs\u00fcn h\u00fccrelere ba\u011flanmas\u0131n\u0131 sa\u011flayan proteinin yapay formu hastal\u0131\u011f\u0131 engelleyebilir mi?"},"content":{"rendered":"

Akci\u011fer hastal\u0131\u011f\u0131na kar\u015f\u0131 test edilmi\u015f bir ila\u00e7, koronavir\u00fcs\u00fcn akci\u011fer ve di\u011fer organlarda art\u0131\u015f\u0131n\u0131 \u00f6nleyerek COVID-19’u etkisiz hale getirme potansiyeline sahip.<\/p>\n

Ara\u015ft\u0131rmac\u0131lara g\u00f6re, sonu\u00e7lar enfeksiyonun erken evrelerinde olan COVID-19 hastalar\u0131n\u0131n tedavisi i\u00e7in umut verici olabilir.<\/p>\n

\u00c7al\u0131\u015fma, SARS-CoV-2\u2019nin kan damarlar\u0131 ve b\u00f6brekler de dahil olmak \u00fczere v\u00fccut h\u00fccrelerini nas\u0131l etkiledi\u011fine dair yeni bilgiler sunuyor. \u00c7al\u0131\u015fma ekibi bu yeni bilgiler do\u011frultusunda COVID-19 hastalar\u0131na yard\u0131mc\u0131 olabilecek yeni bir ila\u00e7 tedavisinin geli\u015ftirilmesine katk\u0131da bulunmay\u0131 umuyorlar.<\/p>\n

\"\"
ACE2 proteini.<\/figcaption><\/figure>\n

Ara\u015ft\u0131rmac\u0131lar, COVID-19 olan bir hastadan al\u0131nan doku \u00f6rneklerini kullanarak, SARS-CoV-2\u2019yi izole edip \u00e7o\u011faltt\u0131lar. Laboratuvar \u00e7al\u0131\u015fmalar\u0131nda vir\u00fcs\u00fcn ACE2 denilen enzimin resept\u00f6rlerine tutunarak h\u00fccre i\u00e7ine girdi\u011fini g\u00f6sterdiler. Bu ayn\u0131 zamanda 2003’teki orijinal SARS vir\u00fcs\u00fcn\u00fcn h\u00fccrelerimize ba\u011flanmak i\u00e7in kulland\u0131\u011f\u0131 ayn\u0131 mekanizmad\u0131r ve \u00f6nceki \u00e7al\u0131\u015fmalarda bir\u00e7ok ara\u015ft\u0131rmac\u0131 taraf\u0131ndan tan\u0131mlanm\u0131\u015ft\u0131r.<\/p>\n

Ara\u015ft\u0131rmac\u0131lar, bu proteinin hrsACE2 ad\u0131 verilen genetik olarak modifiye edilmi\u015f bir varyant\u0131n\u0131 ekleyerek, vir\u00fcs\u00fcn h\u00fccrelere bula\u015fmas\u0131n\u0131 durdurup durdurmayaca\u011f\u0131n\u0131 test etmek istediler. Yay\u0131nlanan sonuca g\u00f6re, hrsACE2, SARS-CoV-2’nin viral b\u00fcy\u00fcmesini h\u00fccre k\u00fclt\u00fcrlerinde azaltt\u0131\u011f\u0131n\u0131 g\u00f6stermektedir.<\/p>\n

Sonu\u00e7lar hrsACE2\u2019nin dozaj\u0131na ba\u011fl\u0131 olarak de\u011fi\u015fti. Yazarlar ayr\u0131ca insan k\u00f6k h\u00fccrelerinden yeti\u015ftirilen organoidlerin yani kan damarlar\u0131n\u0131n ve b\u00f6breklerin minyat\u00fcr kopyalar\u0131ndaki d\u00fczenli h\u00fccre k\u00fclt\u00fcrlerinde bu verileri do\u011frulayabildiler.<\/p>\n

Profes\u00f6r Mirazimi, hrsACE2 varyant enziminin, koronavir\u00fcse ba\u011flanarak etkisiz hale gelmesini sa\u011flad\u0131\u011f\u0131n\u0131 ve b\u00f6ylelikle vir\u00fcs\u00fcn akci\u011ferler ve di\u011fer organlarda \u00e7o\u011falmas\u0131n\u0131 engelleyece\u011fini inand\u0131klar\u0131n\u0131 belirtiyor.<\/p>\n

Ara\u015ft\u0131rma \u015fimdiye kadar h\u00fccre k\u00fclt\u00fcrleri ve minyat\u00fcr organlar ile s\u0131n\u0131rl\u0131yd\u0131, ancak aktif madde ile APN01 ilac\u0131n\u0131 geli\u015ftiren biyoteknoloji \u015firketi Aperion Biologics, \u00c7in’deki enfekte COVID-19 hastalar\u0131 \u00fczerinde klinik bir pilot \u00e7al\u0131\u015fma yapmay\u0131 planl\u0131yor. Ayn\u0131 ila\u00e7, bir klinik faz II \u00e7al\u0131\u015fmas\u0131nda akci\u011fer hastal\u0131\u011f\u0131na kar\u015f\u0131 zaten test edilmi\u015ftir.<\/p>\n

Ara\u015ft\u0131rmac\u0131lar, mevcut \u00e7al\u0131\u015fman\u0131n ilac\u0131n sadece enfeksiyonun ilk a\u015famalar\u0131nda etkisini inceledi\u011fini ve hastal\u0131\u011f\u0131n geli\u015fiminin sonraki a\u015famalar\u0131nda da etkili olup olmad\u0131\u011f\u0131n\u0131 belirlemek i\u00e7in daha fazla ara\u015ft\u0131rmaya ihtiya\u00e7 oldu\u011funu belirtiyor.<\/p>\n

ACE2 genellikle akci\u011ferlerin ve di\u011fer organlar\u0131n normal i\u015flevini s\u00fcrd\u00fcrmesine yard\u0131mc\u0131 olur, ancak vir\u00fcsler proteine ba\u011fland\u0131\u011f\u0131nda h\u00fccrelere zarar verebilir. Ara\u015ft\u0131rmac\u0131lara g\u00f6re bu, baz\u0131 COVID-19 hastalar\u0131n\u0131n neden ciddi akci\u011fer hastal\u0131\u011f\u0131 ve \u00e7oklu organ yetmezli\u011fi ya\u015fad\u0131\u011f\u0131n\u0131 a\u00e7\u0131klayabilir.<\/p>\n

\"\"Organoidlerin yard\u0131m\u0131yla ara\u015ft\u0131rmac\u0131lar, vir\u00fcs\u00fcn do\u011frudan kan damarlar\u0131nda ve b\u00f6breklerde \u00e7o\u011falabilece\u011fini g\u00f6sterdiler. Bu, hastal\u0131\u011f\u0131n geli\u015fimi ve ciddi COVID-19 vakalar\u0131n\u0131n \u00e7oklu organ yetmezli\u011fi ve kardiyovask\u00fcler hasar ile ilgili kan\u0131t olarak \u00f6nemli bilgiler sa\u011flar. hrsACE2 ayr\u0131ca bu tasarlanm\u0131\u015f insan dokular\u0131ndaki SARS-CoV-2 enfeksiyonunu da azaltt\u0131.<\/p>\n

\u00c7al\u0131\u015fman\u0131n yazarlar\u0131ndan Profes\u00f6r Josef Penninger; \u201c\u00d6nceki \u00e7al\u0131\u015fmalar\u0131m\u0131z, ACE2’yi SARS-CoV-2’nin giri\u015f kap\u0131s\u0131 olarak kulland\u0131\u011f\u0131n\u0131 g\u00f6stermek i\u00e7in h\u0131zl\u0131 bir \u015fekilde tan\u0131mlamaya yard\u0131mc\u0131 oldu, bu da hastal\u0131k hakk\u0131nda \u00e7ok \u015fey a\u00e7\u0131kl\u0131yor. Art\u0131k vir\u00fcs\u00fc yakalayan \u00e7\u00f6z\u00fcn\u00fcr bir ACE2 formunun (varyant\u0131 olan hrsACE2) ger\u00e7ekten vir\u00fcs\u00fcn bizi enfekte etmesi i\u00e7in ge\u00e7mesi gereken kap\u0131y\u0131 hedefleyen \u00e7ok rasyonel bir tedavi olabilece\u011fini biliyoruz\u201c diyor.<\/p>\n

Kaynak:<\/strong> https:\/\/neurosciencenews.com\/covid-19-trial-drug-16058\/amp\/<\/p>\n","protected":false},"excerpt":{"rendered":"

Akci\u011fer hastal\u0131\u011f\u0131na kar\u015f\u0131 test edilmi\u015f bir ila\u00e7, koronavir\u00fcs\u00fcn akci\u011fer ve di\u011fer organlarda art\u0131\u015f\u0131n\u0131 \u00f6nleyerek COVID-19’u etkisiz hale getirme potansiyeline sahip. Ara\u015ft\u0131rmac\u0131lara g\u00f6re, sonu\u00e7lar enfeksiyonun erken evrelerinde olan COVID-19 hastalar\u0131n\u0131n tedavisi i\u00e7in umut verici olabilir. \u00c7al\u0131\u015fma, SARS-CoV-2\u2019nin kan damarlar\u0131 ve b\u00f6brekler de dahil olmak \u00fczere v\u00fccut h\u00fccrelerini nas\u0131l etkiledi\u011fine dair yeni bilgiler sunuyor. \u00c7al\u0131\u015fma ekibi bu […]<\/p>\n","protected":false},"author":761,"featured_media":40357,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[5925,5543,5345,5763,5850],"class_list":["post-41578","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-ace2","tag-akciger","tag-enzim","tag-koronavirus","tag-sars"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/41578","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/761"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=41578"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/41578\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media\/40357"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=41578"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=41578"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=41578"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}