{"id":42490,"date":"2020-04-15T13:18:17","date_gmt":"2020-04-15T10:18:17","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=42490"},"modified":"2020-04-15T13:18:17","modified_gmt":"2020-04-15T10:18:17","slug":"kalp-hastaliklarinin-tedavisinde-yeni-umut","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2020\/04\/15\/kalp-hastaliklarinin-tedavisinde-yeni-umut","title":{"rendered":"Kalp hastal\u0131klar\u0131n\u0131n tedavisinde yeni umut"},"content":{"rendered":"

D\u00fcnya \u00e7ap\u0131ndaki \u00f6l\u00fcmlerin ilk s\u0131radaki nedenlerinden olan kalp hastal\u0131klar\u0131n\u0131n tedavisinde etkili bir y\u00f6ntem arayan biliminsanlar\u0131n\u0131n yeni \u00e7al\u0131\u015fmas\u0131, bu hastal\u0131klar\u0131n tedavisi i\u00e7in d\u00f6n\u00fcm noktas\u0131 olabilir.<\/p>\n

\u0130ngiltere\u2019deki Cambridge \u00dcniversitesi’nden ara\u015ft\u0131rmac\u0131lar, hayvan deneyleri s\u0131ras\u0131nda v\u00fccudun di\u011fer b\u00f6lgelerinde kanserle\u015fmeyi te\u015fvik eden fakat kalpte yenilenmeyi sa\u011flayan bir geni raporlad\u0131. S\u00f6z konusu \u00e7al\u0131\u015fma \u00f6nemlidir, \u00e7\u00fcnk\u00fc yeti\u015fkinlerin kalplerindeki hasar genellikle kendili\u011finden onar\u0131lamaz. Mevcut tedaviler ise kalpteki hasar\u0131 tersine d\u00f6nd\u00fcrmez, sadece hasar\u0131n art\u0131\u015f\u0131n\u0131 yava\u015flat\u0131r.<\/p>\n

Ayr\u0131ca Nature Communications\u2019ta yay\u0131nlanan makalenin ba\u015fyazar\u0131 Catherine Wilson \u00e7al\u0131\u015fman\u0131n, kalp kanserinin neden olduk\u00e7a nadir oldu\u011funu da a\u00e7\u0131klayabilece\u011fini belirtiyor.<\/p>\n

Kanserle\u015fme, h\u00fccreler kontrols\u00fcz bir \u015fekilde \u00e7o\u011falmaya ba\u015flad\u0131\u011f\u0131nda geli\u015fir. Myc geni, bu s\u00fcre\u00e7te anahtar bir role sahiptir. Pek \u00e7ok ara\u015ft\u0131rma Myc genini, kanser tedavisi i\u00e7in kontrol alt\u0131na almaya odaklanm\u0131\u015ft\u0131r. Wilson ve ekibi, deneysel a\u015famada Myc genini aktif hale getirdikleri farelerde karaci\u011fer ve akci\u011ferlerin de aralar\u0131nda bulundu\u011fu organlarda kanserle\u015fme g\u00f6rd\u00fcler. Bu organlarda birka\u00e7 g\u00fcn i\u00e7erisinde y\u00fcksek miktarda h\u00fccre \u00e7o\u011falmas\u0131 ya\u015fand\u0131. Ancak farelerin kalbinde kanserle\u015fme ya\u015fanmad\u0131.<\/p>\n

\"\"
Her iki genin aktivitesinin ad\u0131ndan yeti\u015fkin fare kalbi. Ye\u015fil b\u00f6lgeler yeni h\u00fccre olu\u015fumunu g\u00f6sterir.<\/figcaption><\/figure>\n

Biliminsanlar\u0131, kalp kas\u0131 h\u00fccrelerinde Myc aktivitesinin ba\u015fka bir genin aktivitesine ba\u011fl\u0131 oldu\u011funu buldular. Buna g\u00f6re kalpteki Myc g\u00fcd\u00fcml\u00fc aktivite, Ccnt1 geni taraf\u0131ndan \u00fcretilen Cyclin T1 proteininin seviyesine ba\u011fl\u0131d\u0131r. Ccnt1 ve Myc genlerinin aktivasyonu birlikte ger\u00e7ekle\u015fmeye ba\u015flad\u0131\u011f\u0131nda, kalp h\u00fccreleri \u00e7o\u011falmaya ba\u015fl\u0131yordu. Wilson, \u201c\u0130ki gen, yeti\u015fkin farelerin kalp kas\u0131 h\u00fccrelerinde y\u00fcksek d\u00fczeyde anlat\u0131m yapt\u0131\u011f\u0131nda bu b\u00f6lgede yeni h\u00fccrelerin \u00fcretimi ger\u00e7ekle\u015fti. Kalp kas\u0131 h\u00fccrelerinin say\u0131s\u0131nda b\u00fcy\u00fck bir art\u0131\u015f ya\u015fand\u0131\u201d a\u00e7\u0131klamalar\u0131nda bulundu.<\/p>\n

Kalp krizinin ard\u0131ndan yeti\u015fkin bir insan\u0131n kalbinde geri d\u00f6n\u00fc\u015f\u00fcms\u00fcz hasarlar meydana gelebilir, bir milyar kalp h\u00fccresi yitirilebilir. H\u00fccre kay\u0131plar\u0131 kalbin g\u00fcc\u00fcn\u00fc azalt\u0131r, kalp yetmezli\u011fine ve \u00f6l\u00fcme neden olabilecek bir s\u00fcre\u00e7 ba\u015flayabilir. Ara\u015ft\u0131rmac\u0131lar, kalp hastal\u0131\u011f\u0131n\u0131n tedavisi i\u00e7in gen terapisinin kullan\u0131labilece\u011fini d\u00fc\u015f\u00fcn\u00fcyorlar.<\/p>\n

Wilson, \u201cKalpteki Myc ve Cyclin T1 aktivitesini art\u0131rmak i\u00e7in, k\u0131sa s\u00fcreli de\u011fi\u015ftirilebilir teknolojiler kullanmak istiyoruz. B\u00f6ylelikle kanser geli\u015fimine neden olabilecek herhangi bir genetik ayak izi b\u0131rakmayaca\u011f\u0131z\u201d dedi.<\/p>\n

Kaynak:<\/strong> https:\/\/cosmosmagazine.com\/biology\/cancer-gene-could-help-repair-hearts<\/p>\n","protected":false},"excerpt":{"rendered":"

D\u00fcnya \u00e7ap\u0131ndaki \u00f6l\u00fcmlerin ilk s\u0131radaki nedenlerinden olan kalp hastal\u0131klar\u0131n\u0131n tedavisinde etkili bir y\u00f6ntem arayan biliminsanlar\u0131n\u0131n yeni \u00e7al\u0131\u015fmas\u0131, bu hastal\u0131klar\u0131n tedavisi i\u00e7in d\u00f6n\u00fcm noktas\u0131 olabilir. \u0130ngiltere\u2019deki Cambridge \u00dcniversitesi’nden ara\u015ft\u0131rmac\u0131lar, hayvan deneyleri s\u0131ras\u0131nda v\u00fccudun di\u011fer b\u00f6lgelerinde kanserle\u015fmeyi te\u015fvik eden fakat kalpte yenilenmeyi sa\u011flayan bir geni raporlad\u0131. S\u00f6z konusu \u00e7al\u0131\u015fma \u00f6nemlidir, \u00e7\u00fcnk\u00fc yeti\u015fkinlerin kalplerindeki hasar genellikle kendili\u011finden onar\u0131lamaz. […]<\/p>\n","protected":false},"author":1390,"featured_media":42492,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[431,306,2807,444],"class_list":["post-42490","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-gen","tag-hucre","tag-kalp","tag-kanser"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t