{"id":42671,"date":"2012-12-01T00:08:07","date_gmt":"2012-11-30T22:08:07","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=42671"},"modified":"2020-04-19T00:12:06","modified_gmt":"2020-04-18T21:12:06","slug":"kanser-yayilimini-engellemede-buyuk-bulus","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2012\/12\/01\/kanser-yayilimini-engellemede-buyuk-bulus","title":{"rendered":"Kanser yay\u0131l\u0131m\u0131n\u0131 engellemede b\u00fcy\u00fck bulu\u015f"},"content":{"rendered":"

Haz\u0131rlayan:<\/strong> G. P\u0131nar Ger\u00e7ek<\/strong><\/p>\n

Biliminsanlar\u0131 laboratuvar deneylerinde, kanserin t\u00fcm\u00f6rden v\u00fccudun di\u011fer b\u00f6l\u00fcmlerine s\u0131\u00e7ramas\u0131 anlam\u0131na gelen metastaz\u0131n, \u201cmelanoma farkl\u0131la\u015fmas\u0131yla ili\u015fkili gen-9\u201d olarak isimlendirilmi\u015f mda-9\/syntenin proteininin engellenmesini sa\u011flad\u0131.<\/p>\n

Amerika\u2019da her y\u0131l bir milyondan fazla cilt kanseri vakas\u0131 te\u015fhis ediliyor ve melanoma da bunun en \u00f6l\u00fcmc\u00fcl hali. \u0130leri ara\u015ft\u0131rmalarla beraber bu bulu\u015f, melanomada metastaz\u0131 ve potansiyel anlamda \u00e7ok \u00e7e\u015fitli di\u011fer kanserleri durduran hedefli tedavilere yol g\u00f6sterebilir.<\/p>\n

Kanser Ara\u015ft\u0131rmalar\u0131<\/em> (Cancer Research) dergisinde \u00e7evrimi\u00e7i olarak yay\u0131nlanan \u00e7al\u0131\u015fma Virginia Commonwealth \u00dcniversitesi\u2019nde Kanser Molek\u00fcler Geneti\u011fi ve Molek\u00fcler T\u0131p alanlar\u0131nda \u00e7e\u015fitli g\u00f6revlerde bulunan Dr. Paul B. Fisher taraf\u0131ndan y\u00fcr\u00fct\u00fcl\u00fcyor. Fisher ve meslekta\u015flar\u0131, Raf kinaz inhibit\u00f6r proteininin (RKIP) mda-9\/syntenin ile etkile\u015fime girdi\u011fini ve onu bask\u0131lad\u0131\u011f\u0131n\u0131 buldu. Mda-9\/syntenin orijinal olarak Fisher\u2019\u0131n laboratuvar\u0131nda klonland\u0131 ve \u00f6nceki ara\u015ft\u0131rmalarda di\u011fer bir protein olan c-Src ile etkile\u015fti\u011fi g\u00f6sterildi. c-Src ile Mda-9\/syntenin aras\u0131ndaki etkile\u015fim artan metastaz ile sonu\u00e7lanan bir dizi kimyasal reaksiyona yol a\u00e7\u0131yor.<\/p>\n

Fisher: \u201c\u00d6nceki ara\u015ft\u0131rmada, RKIP\u2019\u0131n kanser metastaz\u0131n\u0131 \u00f6nlemede yeni ufuklar a\u00e7an t\u00fcrden bir rol\u00fc oldu\u011fu \u00f6nermesi yap\u0131lm\u0131\u015ft\u0131; fakat \u015fimdiye kadar bu aktivitenin alt\u0131nda yatan mekanizma belli de\u011fildi. Gelecek tedavi y\u00f6ntemlerine yeni bir hedef sa\u011flaman\u0131n yan\u0131nda, bu iki geni melanoma geli\u015fiminin ve ilerlemesinin g\u00f6r\u00fcnt\u00fclenmesi i\u00e7in biyomarker olarak kullanma potansiyeli de var.\u201d<\/p>\n

Biliminsanlar\u0131, deneyleri boyunca RKIP\u2019nin fiziksel olarak mda-9\/syntenin ile ba\u011fland\u0131\u011f\u0131n\u0131 ve bu fiziksel etkile\u015fimin mda-9\/syntenin ifadesini engelledi\u011fini ke\u015ffetti. Bu bulgu RKIP\u2019yi taklit eden k\u00fc\u00e7\u00fck molek\u00fcllerin geli\u015ftirilmesi olas\u0131l\u0131\u011f\u0131n\u0131 ortaya \u00e7\u0131kar\u0131yor. Bu geli\u015ftirilen molek\u00fcller, metastaz\u0131 melanomada ve di\u011fer kanser tiplerinde tedavi ama\u00e7l\u0131 ila\u00e7lar geli\u015ftirmek ad\u0131na kullab\u0131labilecek.<\/p>\n

Buna ek olarak laboratuvar tak\u0131m\u0131 k\u00f6t\u00fc huylu ve metastaz yap\u0131c\u0131 \u00f6zelli\u011fe sahip melanoma h\u00fccrelerindeki mda-9\/syntenin seviyelerinin RKIP\u2019den daha y\u00fcksek oldu\u011funu; fakat sa\u011fl\u0131kl\u0131 melanositlerde (v\u00fccutta cilt, g\u00f6z ve sa\u00e7\u0131n pigmentlerini \u00fcreten h\u00fccreler) mda-9\/syntenin seviyelerinin RKIP\u2019den daha d\u00fc\u015f\u00fck oldu\u011funu buldu. \u0130ki protein aras\u0131ndaki ters orant\u0131l\u0131 ili\u015fki, onlar\u0131n ifade seviyelerindeki de\u011fi\u015fimlerin tan\u0131sal bir ara\u00e7 olarak kullan\u0131labilinece\u011fini, klinisyenlerin hastal\u0131\u011f\u0131n geli\u015fimini izlemesini veya bir hastan\u0131n tedavilere olan tepkisini \u00f6l\u00e7mesini sa\u011flayabilece\u011fini g\u00f6sterdi.<\/p>\n

Fisher: \u201cBulgular\u0131m\u0131z melanomada metastaza yol a\u00e7an genetik mekanizmalar\u0131 anlamam\u0131z\u0131 sa\u011flayan b\u00fcy\u00fck bir bulu\u015fu temsil ediyor. \u00d6nceki \u00e7al\u0131\u015fmalar mda-9\/syntenin seviyelerinin melanoma da dahil olmak \u00fczere kanserlerin \u00e7o\u011funda y\u00fckselmi\u015f oldu\u011funu g\u00f6stermi\u015fti, ki bu da bulgular\u0131m\u0131z\u0131n \u00e7ok say\u0131da hastal\u0131\u011fa uygulanabilir durumda olabilece\u011fi fikrini veriyor\u201d.<\/p>\n

Ara\u015ft\u0131rmac\u0131lar \u015fimdi RKIP\u2019nin mda-9\/synteninin arac\u0131l\u0131k etti\u011fi metastaz\u0131 engelleme yetisine sahip oldu\u011funu ispatlad\u0131\u011f\u0131na g\u00f6re, dikkatlerini RKIP\u2019yi taklit edebilecek ve melanoma i\u00e7in yeni tedavilerde kullan\u0131labilecek k\u00fc\u00e7\u00fck molek\u00fcller geli\u015ftirmeye veriyorlar.<\/p>\n

Kaynak:<\/strong> \u201cResearch Breakthrough Could Halt Melanoma Metastasis, Study Suggests\u201d, http:\/\/www.sciencedaily.com\/releases\/2012\/11\/121114153227.htm.<\/p>\n","protected":false},"excerpt":{"rendered":"

Haz\u0131rlayan: G. P\u0131nar Ger\u00e7ek Biliminsanlar\u0131 laboratuvar deneylerinde, kanserin t\u00fcm\u00f6rden v\u00fccudun di\u011fer b\u00f6l\u00fcmlerine s\u0131\u00e7ramas\u0131 anlam\u0131na gelen metastaz\u0131n, \u201cmelanoma farkl\u0131la\u015fmas\u0131yla ili\u015fkili gen-9\u201d olarak isimlendirilmi\u015f mda-9\/syntenin proteininin engellenmesini sa\u011flad\u0131. Amerika\u2019da her y\u0131l bir milyondan fazla cilt kanseri vakas\u0131 te\u015fhis ediliyor ve melanoma da bunun en \u00f6l\u00fcmc\u00fcl hali. \u0130leri ara\u015ft\u0131rmalarla beraber bu bulu\u015f, melanomada metastaz\u0131 ve potansiyel anlamda \u00e7ok […]<\/p>\n","protected":false},"author":429,"featured_media":42672,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[143,19,38],"tags":[6279,6278,444,4717,6277],"class_list":["post-42671","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-106-sayi","category-bilim-gundemi","category-dergi-sayilari","tag-biyomarker","tag-gen-9","tag-kanser","tag-metastaz","tag-yayilim"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t