Avustralya\u2019n\u0131n ulusal bilim ajans\u0131 olan CSIRO’dan ara\u015ft\u0131rmac\u0131lar, COVID-19 hastal\u0131\u011f\u0131n\u0131n etmeni olan SARS-CoV-2 koronavir\u00fcs\u00fcn\u00fcn genetik dizisinin ve detayl\u0131 plan\u0131n\u0131n analiz edilmesi i\u00e7in kullan\u0131labilecek yeni bir yakla\u015f\u0131m\u0131 ortaya koydu.<\/p>\n
Ara\u015ft\u0131rman\u0131n bulgular\u0131, ara\u015ft\u0131rmac\u0131lar\u0131n vir\u00fcs su\u015flar\u0131n\u0131n nas\u0131l evrimle\u015fti\u011finin anla\u015f\u0131lmas\u0131na ve yeni vir\u00fcs gruplar\u0131n\u0131n belirlenmesine yard\u0131mc\u0131 olacak. Yeni tip koronavir\u00fcs\u00fcn yay\u0131nlanm\u0131\u015f genom dizilerinin k\u00fcresel analizi, karma\u015f\u0131k bir hastal\u0131k olan COVID-19 hakk\u0131ndaki anlay\u0131\u015f\u0131m\u0131z\u0131n geli\u015fmesi sa\u011flayacak. Ara\u015ft\u0131rmac\u0131lar, SARS-CoV-2 koronavir\u00fcs\u00fcn\u00fcn genetik dizisine ili\u015fkin binlerce sonucun aras\u0131ndaki farklar\u0131 belirlemek i\u00e7in, insan genomunun analizi i\u00e7in kullan\u0131lan biyoinformatik temelli y\u00f6ntemlerle desteklenen yeni bir g\u00f6rselle\u015ftirme metodu geli\u015ftirdiler.<\/p>\n
CSIRO y\u00f6netiminden Dr. Larry Marshall, koronavir\u00fcs\u00fcn genetik dizisinin bilinmesinin \u00e7ok \u00f6nemli oldu\u011funu vurgulayarak \u201cVir\u00fcs hakk\u0131nda ne kadar \u00e7ok \u015feyi bilirsek, onunla sava\u015fma konusunda o kadar s\u0131k\u0131 bir \u015fekilde silahlanm\u0131\u015f olaca\u011f\u0131z\u201d dedi ve ekledi: \u201cSARS-CoV-2 koronavir\u00fcs\u00fcn\u00fcn genom dizisine ili\u015fkin y\u00fcksek karma\u015f\u0131kl\u0131k d\u00fczeyindeki analiz, Geelong\u2019taki Avustralya Hastal\u0131k Haz\u0131rl\u0131k Merkezi’nde devam eden a\u015f\u0131 \u00e7al\u0131\u015fmalar\u0131 testleri i\u00e7in vir\u00fcs\u00fcn hangi su\u015funun uygun oldu\u011funun belirlenmesinde yard\u0131mc\u0131 oldu.\u201d<\/p>\n
CSIRO’daki Biyoinformatik tak\u0131m\u0131n y\u00fcr\u00fct\u00fcc\u00fcs\u00fc Dr. Denis Bauer, vir\u00fcs evrim ge\u00e7irdik\u00e7e, vir\u00fcs\u00fcn detayl\u0131 yap\u0131 analizinin giderek daha da \u00f6nemli bir hale geldi\u011fini, \u00e7\u00fcnk\u00fc bu analizin vir\u00fcs\u00fcn davran\u0131\u015f\u0131 ve ne t\u00fcrden hastal\u0131klara neden olabilece\u011fi hakk\u0131nda bilgiler i\u00e7erdi\u011fini belirtti.<\/p>\n
Ayn\u0131 zamanda Avustralya’daki Macquarie \u00dcniversitesi’nde Fahri Do\u00e7ent olan Dr. Bauer, \u201cArt\u0131k k\u00fcresel \u00f6l\u00e7ekte etkili olan \u00e7ok say\u0131da, birbirlerinden farkl\u0131 vir\u00fcs dizisi var. Elde edilen veriler aras\u0131ndaki evrimsel uzakl\u0131\u011f\u0131n de\u011ferlendirilmesi ve verilerin g\u00f6rselle\u015ftirilmesi, vir\u00fcs su\u015flar\u0131 aras\u0131ndaki farklar\u0131n kayna\u011f\u0131n\u0131n ve vir\u00fcs su\u00e7lar\u0131n\u0131n nas\u0131l evrimle\u015ftiklerinin anla\u015f\u0131lmas\u0131na yard\u0131mc\u0131 oluyor\u201d dedi.<\/p>\n
CSIRO’nun Tehlikeli Patojenler tak\u0131m\u0131n\u0131n y\u00fcr\u00fct\u00fcc\u00fcs\u00fc olan ve SARS-CoV-2 \u00e7al\u0131\u015fmalar\u0131 ile a\u015f\u0131 ara\u015ft\u0131rmalar\u0131na liderlik eden Prof. S. S. Vassan, vir\u00fcsteki de\u011fi\u015fimlerin vir\u00fcs davran\u0131\u015f\u0131n\u0131 ve tesirini nas\u0131l etkileyece\u011finin anla\u015f\u0131lmas\u0131 i\u00e7in SARS-CoV-2 salg\u0131n\u0131n\u0131n ba\u015flang\u0131c\u0131nda yay\u0131nlanan ilk 181 genom dizisinin analiz edildi\u011fini s\u00f6yledi: \u201cTeyit etti\u011fimiz ve g\u00f6rselle\u015ftirdi\u011fimiz \u00e7al\u0131\u015fmaya g\u00f6re, bu RNA vir\u00fcs\u00fcn\u00fcn mutasyonlar\u0131 payla\u015fan farkl\u0131 k\u00fcmelere evrimle\u015fmeleri beklenmektedir. Bu analizin \u015fu anda, COVID-19 te\u015fhisi, tedavisi ve a\u015f\u0131 geli\u015ftirme \u00e7al\u0131\u015fmalar\u0131n\u0131 etkilemesini beklemiyoruz. Ancak bu bilgiler, klinik \u00e7al\u0131\u015fmalar \u00f6ncesinde ve klinik \u00e7al\u0131\u015fmalar ilerledik\u00e7e izlenmesi gereken \u00f6nemli bilgilerdir.\u201d<\/p>\n
Dr. Bauer, “Veri g\u00f6rselle\u015ftirmenin avantaj\u0131, de\u011fi\u015fmeye ve yeni ortamlara uyum sa\u011flamaya devam eden vir\u00fcs\u00fcn genetik mutasyonlar\u0131n\u0131n ayd\u0131nlat\u0131lmas\u0131d\u0131r\u201d diyerek \u00e7al\u0131\u015fman\u0131n \u00f6nemine vurgu yapt\u0131.<\/p>\n
Kaynak:<\/strong> https:\/\/medicalxpress.com\/news\/2020-04-team-evolving-strains-sars-cov-.html<\/p>\n Su\u015f nedir? Koronavir\u00fcs k\u00fcresel salg\u0131n\u0131 s\u0131ras\u0131nda s\u0131k\u00e7a kar\u015f\u0131la\u015ft\u0131\u011f\u0131m\u0131z terimler ne anlama geliyor? Bilim ve Gelecek’in koronavir\u00fcs s\u00f6zl\u00fc\u011f\u00fc salg\u0131n g\u00fcndeminde s\u0131kl\u0131kla kar\u015f\u0131la\u015ft\u0131\u011f\u0131m\u0131z terimlerin a\u00e7\u0131klamalar\u0131n\u0131 sunuyor: Koronavir\u00fcs S\u00f6zl\u00fc\u011f\u00fc<\/a><\/p>\n","protected":false},"excerpt":{"rendered":" Avustralya\u2019n\u0131n ulusal bilim ajans\u0131 olan CSIRO’dan ara\u015ft\u0131rmac\u0131lar, COVID-19 hastal\u0131\u011f\u0131n\u0131n etmeni olan SARS-CoV-2 koronavir\u00fcs\u00fcn\u00fcn genetik dizisinin ve detayl\u0131 plan\u0131n\u0131n analiz edilmesi i\u00e7in kullan\u0131labilecek yeni bir yakla\u015f\u0131m\u0131 ortaya koydu. Ara\u015ft\u0131rman\u0131n bulgular\u0131, ara\u015ft\u0131rmac\u0131lar\u0131n vir\u00fcs su\u015flar\u0131n\u0131n nas\u0131l evrimle\u015fti\u011finin anla\u015f\u0131lmas\u0131na ve yeni vir\u00fcs gruplar\u0131n\u0131n belirlenmesine yard\u0131mc\u0131 olacak. Yeni tip koronavir\u00fcs\u00fcn yay\u0131nlanm\u0131\u015f genom dizilerinin k\u00fcresel analizi, karma\u015f\u0131k bir hastal\u0131k olan COVID-19 […]<\/p>\n","protected":false},"author":1390,"featured_media":42882,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[5763,5764,5827,6331],"class_list":["post-42881","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-koronavirus","tag-salgin","tag-sars-cov-2","tag-sus"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t
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