{"id":44894,"date":"2020-06-18T14:21:37","date_gmt":"2020-06-18T11:21:37","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=44894"},"modified":"2020-06-18T14:23:38","modified_gmt":"2020-06-18T11:23:38","slug":"hastalik-yapici-mantarlarin-bagisiklik-sisteminden-kacabilmesine-yardimci-olan-enzim-kesfedildi","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2020\/06\/18\/hastalik-yapici-mantarlarin-bagisiklik-sisteminden-kacabilmesine-yardimci-olan-enzim-kesfedildi","title":{"rendered":"Hastal\u0131k yap\u0131c\u0131 mantarlar\u0131n ba\u011f\u0131\u015f\u0131kl\u0131k sisteminden ka\u00e7abilmesine yard\u0131mc\u0131 olan enzim ke\u015ffedildi"},"content":{"rendered":"<p><em>Aspergillus fumigatus<\/em>, organ nakli yap\u0131lm\u0131\u015f veya kanser tedavisi i\u00e7in kemoterapi alanlarlar gibi ba\u011f\u0131\u015f\u0131kl\u0131k yetersizli\u011fi olan bireylerde ciddi sonu\u00e7lara neden olabilen bir mantar t\u00fcr\u00fcd\u00fcr. Her y\u0131l say\u0131s\u0131 500.000\u2019i bulan Aspergillus kaynakl\u0131 hastal\u0131k vakas\u0131 rapor ediliyor. Vakalarda mantarlara kar\u015f\u0131 m\u00fccadele i\u00e7in \u00f6nemli olan antifungal ajanlar bulunsa bile hastal\u0131k kaynakl\u0131 \u00f6l\u00fcm oran\u0131 y\u00fczde 50\u2019nin \u00fczerinde kal\u0131yor.<\/p>\n<figure id=\"attachment_44896\" aria-describedby=\"caption-attachment-44896\" style=\"width: 296px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-44896 size-medium\" src=\"https:\/\/bilimvegelecek.com.tr\/wp-content\/uploads\/2020\/06\/Aspergillus-fumigatus-1-296x300.jpg\" alt=\"\" width=\"296\" height=\"300\" srcset=\"https:\/\/bilimvegelecek.com.tr\/wp-content\/uploads\/2020\/06\/Aspergillus-fumigatus-1-296x300.jpg 296w, https:\/\/bilimvegelecek.com.tr\/wp-content\/uploads\/2020\/06\/Aspergillus-fumigatus-1-100x100.jpg 100w, https:\/\/bilimvegelecek.com.tr\/wp-content\/uploads\/2020\/06\/Aspergillus-fumigatus-1.jpg 356w\" sizes=\"auto, (max-width: 296px) 100vw, 296px\" \/><figcaption id=\"caption-attachment-44896\" class=\"wp-caption-text\">Aspergillus fumigatus&#8217;un mikroskop alt\u0131ndaki g\u00f6r\u00fcnt\u00fcs\u00fc.<\/figcaption><\/figure>\n<p><em>A. fumigatus<\/em> kaynakl\u0131 enfeksiyonlar\u0131n tedavi edilmesi zordur. \u00c7\u00fcnk\u00fc enfeksiyon s\u0131ras\u0131nda mantarlar biyofilm ad\u0131 verilen k\u00fc\u00e7\u00fck topluluklar halinde birikir. Biyofilmler hastal\u0131k yap\u0131c\u0131 (patojen) mikroorganizmalar\u0131 antifungal ajanlardan korumakla kalmaz, ayn\u0131 zamanda mantar h\u00fccrelerinin ba\u011f\u0131\u015f\u0131kl\u0131k sisteminden ka\u00e7malar\u0131na da yard\u0131mc\u0131 olur. D\u00fcnya genelinde ara\u015ft\u0131rmac\u0131lar biyofilmlerin nas\u0131l \u00fcretildi\u011fini ve biyofilmlerin yap\u0131s\u0131n\u0131 bozmak i\u00e7in neler yap\u0131labilece\u011fini anlamaya \u00e7al\u0131\u015f\u0131yorlar. \u00c7\u00fcnk\u00fc bu bilginin edinilmesi etkili tedavi yakla\u015f\u0131mlar\u0131 geli\u015ftirmek i\u00e7in \u00f6nemli olacakt\u0131r.<\/p>\n<p>Nature Communications\u2019ta yay\u0131nlanan makalede, ara\u015ft\u0131rmac\u0131lar Dr. Lynne Howell ve Dr. Don Sheppard, &#8220;Agd3&#8221; olarak adland\u0131r\u0131lan ve <em>A. fumigatus<\/em>&#8216;ta biyofilm olu\u015fumu i\u00e7in kritik konumda olan enzimin yap\u0131s\u0131n\u0131 \u00e7\u00f6zd\u00fcklerini raporlad\u0131.<\/p>\n<p>Howell ve Sheppard, alt\u0131 y\u0131ldan uzun bir s\u00fcredir farkl\u0131 patojenler taraf\u0131ndan \u00fcretilen biyofilmlerdeki g\u00fcvenlik a\u00e7\u0131klar\u0131n\u0131 bulmak i\u00e7in birlikte \u00e7al\u0131\u015f\u0131yorlard\u0131. Bu konuyla ilgili ara\u015ft\u0131rmalar\u0131nda daha spesifik bir konu \u00fczerine de e\u011fildiler: Patojenler taraf\u0131ndan farkl\u0131 enzimler kullan\u0131larak \u00fcretilen bir grup karbonhidrat polimeri \u00fczerinde de \u00e7al\u0131\u015f\u0131yorlard\u0131. \u0130\u015fte bu karbonhidrat polimerleri biyofilm yap\u0131lar\u0131n\u0131n bir arada tutulmas\u0131nda g\u00fc\u00e7l\u00fc bir tutkal g\u00f6revi g\u00f6r\u00fcyordu.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-44898 alignright\" src=\"https:\/\/bilimvegelecek.com.tr\/wp-content\/uploads\/2020\/06\/Aspergillus-fumigatus-2.jpg\" alt=\"\" width=\"274\" height=\"184\" \/>Sheppard, \u201cBu karbonhidratlar\u0131n nas\u0131l sentezlendi\u011fini ve hangi enzimlerin \u00fcretimlerinde etkili oldu\u011funu bilmek istiyoruz. \u00c7\u00fcnk\u00fc biyofilmlerin nas\u0131l \u00fcretildiklerini bilirsek, onlar\u0131 nas\u0131l par\u00e7alayaca\u011f\u0131m\u0131z\u0131 da biliriz\u201d diyor. Biyofilmler \u00fczerinde \u00e7al\u0131\u015fma yapan ekip, Agd3 enzimi eksikli\u011finde biyofilmin olu\u015fmad\u0131\u011f\u0131n\u0131 ve mantar\u0131n etkinli\u011finin zay\u0131flad\u0131\u011f\u0131n\u0131 ke\u015ffetti. Ard\u0131ndan enzim eksikli\u011fi olan mantara enzimi yerle\u015ftirdikten sonra, Agd3 enziminin biyofilm olu\u015fumunda etkili oldu\u011fu mekanizmay\u0131 anlamak i\u00e7in enzimin 3 boyutlu yap\u0131s\u0131n\u0131 analiz etmeye ba\u015flad\u0131lar. Howell, \u00e7al\u0131\u015fmalar\u0131 s\u0131ras\u0131nda enzimin karbonhidrat polimerlerine hangi b\u00f6lgelerden ve nas\u0131l ba\u011fland\u0131\u011f\u0131n\u0131 g\u00f6rselle\u015ftirebildiklerini ifade ediyor. Ara\u015ft\u0131rmac\u0131lar \u00e7al\u0131\u015fma s\u0131ras\u0131nda enzimin ka\u00e7 farkl\u0131 b\u00f6lgeden olu\u015ftu\u011funu da ke\u015ffedebildi. B\u00f6ylece enzimin yap\u0131s\u0131na dair yeni bilgiler edinildi. Howell enzimin yap\u0131s\u0131na dair analizin, daha \u00f6nceki \u00e7al\u0131\u015fmalarda tan\u0131mlanmam\u0131\u015f olan ancak karbonhidratlar\u0131n i\u015flenmesinde g\u00f6revli olan enzim ailesinin tan\u0131mlanmas\u0131na yard\u0131mc\u0131 oldu\u011funu belirtiyor.<\/p>\n<p><em>A. fumigatus<\/em>&#8216;un antifungal ajanlara kar\u015f\u0131 geli\u015ftirdi\u011fi diren\u00e7 d\u00fcnya \u00e7ap\u0131nda bir sa\u011fl\u0131k tehdidi olmaya devam ediyor. Dolay\u0131s\u0131yla biliminsanlar\u0131n\u0131n direncin geli\u015ftirilmesine dolayl\u0131 yoldan arac\u0131l\u0131k eden Agd3&#8217;\u00fcn yap\u0131s\u0131na ili\u015fkin bilgileri a\u00e7\u0131\u011fa \u00e7\u0131karmalar\u0131 direnci k\u0131rmaya y\u00f6nelik stratejileri de beraberinde getirecektir. Asl\u0131nda ara\u015ft\u0131rmac\u0131lar bu konuda da ad\u0131m atm\u0131\u015f durumdalar. Sheppard, \u201cYap\u0131ya dair edindi\u011fimiz bilgilere dayanarak Agd3&#8217;\u00fcn i\u015flevini engelleyebilen antikorlar tasarl\u0131yoruz\u201d a\u00e7\u0131klamas\u0131nda bulundu.<\/p>\n<p><strong>Kaynak:<\/strong> https:\/\/phys.org\/news\/2020-06-family-enzymes-reveals-achilles-heel.html<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aspergillus fumigatus, organ nakli yap\u0131lm\u0131\u015f veya kanser tedavisi i\u00e7in kemoterapi alanlarlar gibi ba\u011f\u0131\u015f\u0131kl\u0131k yetersizli\u011fi olan bireylerde ciddi sonu\u00e7lara neden olabilen bir mantar t\u00fcr\u00fcd\u00fcr. Her y\u0131l say\u0131s\u0131 500.000\u2019i bulan Aspergillus kaynakl\u0131 hastal\u0131k vakas\u0131 rapor ediliyor. Vakalarda mantarlara kar\u015f\u0131 m\u00fccadele i\u00e7in \u00f6nemli olan antifungal ajanlar bulunsa bile hastal\u0131k kaynakl\u0131 \u00f6l\u00fcm oran\u0131 y\u00fczde 50\u2019nin \u00fczerinde kal\u0131yor. A. fumigatus [&hellip;]<\/p>\n","protected":false},"author":1390,"featured_media":44897,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[6829,2413,6830,5141],"class_list":["post-44894","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-aspergillus-fumigatus","tag-bagisiklik-sistemi","tag-biyofilm","tag-mantar"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/44894","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1390"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=44894"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/44894\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media\/44897"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=44894"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=44894"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=44894"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}