Ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fc\u015f\u00fc\u015f\u00fc ya\u015fl\u0131l\u0131kta kar\u015f\u0131la\u015f\u0131lan durumlardan biridir. Bern \u00dcniversitesi\u2019nden ve Bern \u00dcniversite Hastanesi\u2019nden ara\u015ft\u0131rmac\u0131lar\u0131n yeni \u00e7al\u0131\u015fmas\u0131, ya\u015fa ba\u011fl\u0131 bozukluklar\u0131n yeni bir yakla\u015f\u0131m kullan\u0131larak durdurulabilece\u011fini ve k\u0131smen de olsa eski hale d\u00f6n\u00fc\u015f\u00fcn sa\u011flanabilece\u011fini ortaya koyuyor.<\/p>\n
Ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin fonksiyonu ya\u015f ilerledik\u00e7e azalma periyoduna girer, bu nedenle ya\u015fl\u0131 insanlar bula\u015f\u0131c\u0131 hastal\u0131klara daha kolay yakalanabilir. S\u00f6z konusu durumun etkisi grip, COVID-19 gibi hastal\u0131klar\u0131n salg\u0131nlara d\u00f6n\u00fc\u015ft\u00fc\u011f\u00fc d\u00f6nemlerde daha da belirgin hale gelir. Ara\u015ft\u0131rmac\u0131lar artan h\u0131zla ya\u015flanan pop\u00fclasyonda sa\u011fl\u0131kl\u0131 ya\u015fam s\u00fcresini art\u0131rmak i\u00e7in benimsenebilecek yeni bir yakla\u015f\u0131m geli\u015ftirmek i\u00e7in yola \u00e7\u0131kt\u0131. Biliminsanlar\u0131 uzun y\u0131llar boyunca kronik d\u00fc\u015f\u00fck dereceli inflamasyonun (low-grade inflammation) ya\u015flanma s\u00fcre\u00e7lerini ve ya\u015fa ba\u011fl\u0131 bozukluklar\u0131n geli\u015fimini h\u0131zland\u0131rd\u0131\u011f\u0131n\u0131 d\u00fc\u015f\u00fcn\u00fcyorlard\u0131. Daha \u00f6nceki \u00e7al\u0131\u015fmalar, viseral (i\u00e7 organlarla ilgili\/i\u00e7 organlardaki) ya\u011f dokusunun kronik d\u00fc\u015f\u00fck dereceli inflamasyonun geli\u015fimine y\u00fcksek oranda katk\u0131 sa\u011flad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015fti. Bern \u00dcniversitesi\u2019nden ara\u015ft\u0131rmac\u0131lar\u0131n \u00e7al\u0131\u015fmas\u0131 bu dokudaki baz\u0131 ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerinin kronik d\u00fc\u015f\u00fck dereceli inflamasyon ve ya\u015flanma s\u00fcre\u00e7lerinin d\u00fczenlenmesinde \u00f6nemli bir rol oynad\u0131\u011f\u0131n\u0131 ortaya koydu. Biliminsanlar\u0131 doku i\u00e7erisindeki h\u00fccrelerin ya\u015flanmaya ba\u011fl\u0131 ba\u011f\u0131\u015f\u0131kl\u0131k s\u00fcre\u00e7lerini tersine \u00e7evirmek i\u00e7in kullan\u0131labilece\u011fini raporlad\u0131.<\/p>\n
Nature Metabolism<\/em> dergisinde yay\u0131nlanan \u00e7al\u0131\u015fmada ekip, eozinofiller olarak bilinen ve \u00e7o\u011funlukla kan dola\u015f\u0131m\u0131nda bulunan belirli bir t\u00fcr ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccresinin hem insanlar\u0131n hem de farelerin viseral ya\u011f dokusunda bulundu\u011funu g\u00f6sterdi. Bu h\u00fccrelerin parazitik enfeksiyonlardan koruma sa\u011flad\u0131\u011f\u0131 bilinse de, viseral ya\u011f dokusundaki eozinofiller yerel ba\u011f\u0131\u015f\u0131kl\u0131k homeostaz\u0131n\u0131 (i\u00e7 denge\/denge) korumaktan sorumludur. Ya\u015f ilerledik\u00e7e viseral ya\u011f dokusundaki eozinofillerin s\u0131kl\u0131\u011f\u0131 azal\u0131r, pro-enflamatuar makrofajlar\u0131n say\u0131s\u0131 artar: Bu d\u00f6nedeki ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccresi dengesizli\u011fi nedeniyle, ya\u015fl\u0131l\u0131kta viseral ya\u011f dokusu pro-enflamatuar (inflamasyona sebep olabilecek nitelikte olan) arac\u0131lar\u0131n bir kayna\u011f\u0131na d\u00f6n\u00fc\u015f\u00fcr.<\/p>\n Ara\u015ft\u0131rmac\u0131lar \u00e7al\u0131\u015fmalar\u0131n\u0131n bir sonraki ad\u0131m\u0131nda viseral ya\u011f dokusundaki ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccresi dengesi eski haline getirildi\u011finde ya\u015fa ba\u011fl\u0131 bozukluklarda nas\u0131l bir de\u011fi\u015fim oldu\u011funa odakland\u0131: Bu de\u011fi\u015fiklikleri tersine \u00e7evirmek m\u00fcmk\u00fcn m\u00fcyd\u00fc? \u00c7al\u0131\u015fman\u0131n y\u00fcr\u00fct\u00fcc\u00fclerinden Dr. Alexander Eggel, \u201cFarkl\u0131 deneysel yakla\u015f\u0131mlarda gen\u00e7 farelerden ya\u015fl\u0131 al\u0131c\u0131lara eozinofil transferinin sadece yerel bir etkiye sahip olmad\u0131\u011f\u0131n\u0131, ayn\u0131 zamanda d\u00fc\u015f\u00fck dereceli inflamasyonu da \u00e7\u00f6zd\u00fc\u011f\u00fcn\u00fc g\u00f6rd\u00fck\u201d a\u00e7\u0131klamalar\u0131nda bulundu. \u00c7al\u0131\u015fman\u0131n di\u011fer y\u00fcr\u00fct\u00fcc\u00fcs\u00fc Dr. Mario Noti, \u201cDeneylerde, aktar\u0131lan eozinofillerin se\u00e7ici olarak ya\u011f dokusuna girdi\u011fi g\u00f6zlemlenmi\u015ftir\u201d dedi. Sonu\u00e7 olarak, bu yakla\u015f\u0131m\u0131n ya\u015fl\u0131 organizma \u00fczerinde gen\u00e7le\u015ftirici etkisi oldu. Ayr\u0131ca tedavi, ya\u015fl\u0131 farelerin ba\u011f\u0131\u015f\u0131kl\u0131k sistemi \u00fczerinde de gen\u00e7le\u015ftirici bir etkiye sahipti. Biliminsanlar\u0131 \u00e7al\u0131\u015fmalar\u0131ndaki bir sonraki a\u015faman\u0131n, bu bilgiler \u0131\u015f\u0131\u011f\u0131nda insanlarda sa\u011fl\u0131kl\u0131 ya\u015flanmay\u0131 te\u015fvik etmek ve s\u00fcrd\u00fcrmek i\u00e7in kullan\u0131labilecek terap\u00f6tik (tedavi edici) yakla\u015f\u0131mlar geli\u015ftirmek olaca\u011f\u0131n\u0131 s\u00f6yl\u00fcyor.<\/p>\n