{"id":47101,"date":"2020-11-16T10:07:23","date_gmt":"2020-11-16T07:07:23","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=47101"},"modified":"2020-11-16T10:07:23","modified_gmt":"2020-11-16T07:07:23","slug":"melatonin-hormonu-uykuyu-nasil-tesvik-eder","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2020\/11\/16\/melatonin-hormonu-uykuyu-nasil-tesvik-eder","title":{"rendered":"Melatonin hormonu, uykuyu nas\u0131l te\u015fvik eder?"},"content":{"rendered":"

Melatonin, uyku ile ili\u015fkilendirilen bir hormondur ancak \u015fimdiye kadarki \u00e7al\u0131\u015fmalar melatoninin beyindeki \u00e7al\u0131\u015fma mekanizmas\u0131n\u0131 b\u00fct\u00fcn\u00fcyle a\u00e7\u0131klayamam\u0131\u015ft\u0131. UConn Health’den biliminsanlar\u0131, solucanlar\u0131 kullanarak melatonin ile uyku aras\u0131ndaki ili\u015fkiyi \u00e7\u00f6zmeye \u00e7al\u0131\u015ft\u0131. \u00c7al\u0131\u015fma, melatoninin solucanlar\u0131n da uyumas\u0131na yard\u0131mc\u0131 oldu\u011funu g\u00f6steriyor.<\/p>\n

V\u00fccudumuz karanl\u0131k ortamda melatonin \u00fcretimine ba\u015flar. Bir hormon olan melatonin, herhangi bir eksiklik durumunda doktor tavsiyesiyle d\u0131\u015far\u0131dan al\u0131nabilir.<\/p>\n

Melatonin hormonu, uykuyu te\u015fvik eden etkilerini \u00fcretebilmek i\u00e7in \u00f6ncelikle beyindeki melatonin resept\u00f6rlerine ba\u011flan\u0131r. Resept\u00f6r ve hormon aras\u0131nda kurulan anahtar-kilit ili\u015fkisi, melatoninin etkilerinin a\u00e7\u0131\u011fa \u00e7\u0131kmas\u0131n\u0131 sa\u011flar. Melatoninin ba\u011fland\u0131\u011f\u0131 iki \u201ckilit\u201d yani resept\u00f6r bulunur, bunlar MT1 ve MT2 olarak adland\u0131r\u0131l\u0131r. Ancak ara\u015ft\u0131rmac\u0131lar kilit a\u00e7\u0131ld\u0131\u011f\u0131nda ne olaca\u011f\u0131n\u0131 t\u00fcm detaylar\u0131 ile bilmiyorlard\u0131. PNAS<\/em> portal\u0131nda yay\u0131nlanan yeni \u00e7al\u0131\u015fma, bu i\u015flevin C. elegans<\/em> solucanlar\u0131nda da oldu\u011funu g\u00f6sterdi. Biliminsanlar\u0131 s\u00f6z konusu s\u00fcreci tan\u0131mlamak i\u00e7in solucanlarla \u00e7al\u0131\u015f\u0131labilece\u011fini ifade ediyor. Buna g\u00f6re, melatonin, solucan beynindeki MT1 resept\u00f6r\u00fcne ba\u011fland\u0131\u011f\u0131nda BK kanal\u0131 olarak bilinen bir potasyum kanal\u0131n\u0131 a\u00e7ar.<\/p>\n

BK kanal\u0131nda bulunan n\u00f6ronlar\u0131n \u00f6nemli i\u015flevlerinden biri, n\u00f6ronlar aras\u0131 ileti\u015fimin temeli olan kimyasallar\u0131n, n\u00f6rotransmitterlerin sal\u0131n\u0131m\u0131n\u0131 s\u0131n\u0131rland\u0131rmakt\u0131r. Yeni ara\u015ft\u0131rma s\u0131ras\u0131nda, BK kanal\u0131n\u0131n n\u00f6rotransmiter sal\u0131n\u0131m\u0131n\u0131 s\u0131n\u0131rland\u0131rmas\u0131 i\u00e7in bir melatonin resept\u00f6r\u00fcne ihtiya\u00e7 oldu\u011fu bulundu. Melatoninin, resept\u00f6rler arac\u0131\u011f\u0131yla BK kanal\u0131n\u0131 aktifle\u015ftirip solucanlarda uykunun te\u015fvik edilmesinde etkili oldu\u011fu ke\u015ffedildi.<\/p>\n

Ara\u015ft\u0131rma bu temel \u00fczerine kurulu ama solucanlar uyur mu?<\/strong><\/p>\n

Solucanlar\u0131n uyku durumu \u00fczerine yap\u0131lm\u0131\u015f epeyce ara\u015ft\u0131rma var. Biliminsanlar\u0131, solucanlar\u0131n uyku durumunun fare veya insan gibi memelilerle benzerlik g\u00f6sterdi\u011fini ifade ediyor. Ayr\u0131ca ara\u015ft\u0131rmalar melatonin, melatonin resept\u00f6r\u00fc veya BK kanal\u0131 bulunmayan solucanlar\u0131n uykuda daha az zaman harcad\u0131klar\u0131n\u0131 g\u00f6steriyor.<\/p>\n

Biliminsanlar\u0131 ke\u015fiflerini ba\u015fka ara\u015ft\u0131rmalarla da do\u011frulayarak hem melatonini daha iyi anlamay\u0131 hem de BK kanal\u0131yla ilgili di\u011fer hastal\u0131klar\u0131n tedavisi i\u00e7in neler yap\u0131labilece\u011fini g\u00f6rmeyi planl\u0131yorlar.<\/p>\n

Kaynak:<\/strong> https:\/\/medicalxpress.com\/news\/2020-11-worms-reveal-melatonin.html<\/p>\n","protected":false},"excerpt":{"rendered":"

Melatonin, uyku ile ili\u015fkilendirilen bir hormondur ancak \u015fimdiye kadarki \u00e7al\u0131\u015fmalar melatoninin beyindeki \u00e7al\u0131\u015fma mekanizmas\u0131n\u0131 b\u00fct\u00fcn\u00fcyle a\u00e7\u0131klayamam\u0131\u015ft\u0131. UConn Health’den biliminsanlar\u0131, solucanlar\u0131 kullanarak melatonin ile uyku aras\u0131ndaki ili\u015fkiyi \u00e7\u00f6zmeye \u00e7al\u0131\u015ft\u0131. \u00c7al\u0131\u015fma, melatoninin solucanlar\u0131n da uyumas\u0131na yard\u0131mc\u0131 oldu\u011funu g\u00f6steriyor. V\u00fccudumuz karanl\u0131k ortamda melatonin \u00fcretimine ba\u015flar. Bir hormon olan melatonin, herhangi bir eksiklik durumunda doktor tavsiyesiyle d\u0131\u015far\u0131dan al\u0131nabilir. Melatonin […]<\/p>\n","protected":false},"author":1390,"featured_media":36680,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[7086,7087,5302,418],"class_list":["post-47101","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-melatonin","tag-reseptor","tag-solucan","tag-uyku"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t