{"id":48227,"date":"2021-01-08T10:37:39","date_gmt":"2021-01-08T07:37:39","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=48227"},"modified":"2021-01-08T10:37:39","modified_gmt":"2021-01-08T07:37:39","slug":"hucre-bolunmesinde-onemli-bir-durak-noktasi-olan-bekleme-sinyalinin-mekanizmasi-aydinlatildi","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2021\/01\/08\/hucre-bolunmesinde-onemli-bir-durak-noktasi-olan-bekleme-sinyalinin-mekanizmasi-aydinlatildi","title":{"rendered":"H\u00fccre b\u00f6l\u00fcnmesinde \u00f6nemli bir durak noktas\u0131 olan “bekleme” sinyalinin mekanizmas\u0131 ayd\u0131nlat\u0131ld\u0131"},"content":{"rendered":"

\u00c7ok h\u00fccreli organizmalar, tek bir h\u00fccreden k\u00f6ken al\u0131rlar ve sonucunda kemikler, kalp, beyin ve di\u011fer bile\u015fenlerin olu\u015ftu\u011fu milyonlarca h\u00fccre b\u00f6l\u00fcnmesi ya\u015farlar. Bu s\u00fcre\u00e7teki ana kaynak, DNA’n\u0131n kromozom ad\u0131 verilen ayr\u0131 paketler i\u00e7inde h\u00fccre b\u00f6l\u00fcnmesi yoluyla yeni h\u00fccrelere aktar\u0131lmas\u0131d\u0131r.<\/p>\n

T\u00fcm kromozomlar\u0131n kopyalanmas\u0131 ve her h\u00fccre b\u00f6l\u00fcnmesinde yeni h\u00fccrelere hassas bir \u015fekilde da\u011f\u0131t\u0131lmas\u0131 \u00e7ok \u00f6nemlidir. Kromozom bile\u015fenlerinin da\u011f\u0131l\u0131m\u0131 az da olsa de\u011fi\u015firse, do\u011fum kusurlar\u0131 ve kanser gibi hastal\u0131klar ortaya \u00e7\u0131kabilir.<\/p>\n

Science<\/em> dergisinde yay\u0131nlanan yeni \u00e7al\u0131\u015fmada, h\u00fccrenin her bir b\u00f6l\u00fcnmesinde kromozomlar\u0131n nas\u0131l do\u011fru bir \u015fekilde h\u00fccrelere aktar\u0131ld\u0131\u011f\u0131na odaklan\u0131ld\u0131. Biliminsanlar\u0131 yeni bir metot kullanarak h\u00fccre b\u00f6l\u00fcnmesi i\u00e7in \u00f6nemli bir durak noktas\u0131 olan \u201cbekleme\u201d sinyalinin mekanizmas\u0131n\u0131 detayland\u0131rd\u0131.<\/p>\n

Ara\u015ft\u0131rmac\u0131lar, h\u00fccre b\u00f6l\u00fcnmesi s\u0131ras\u0131nda do\u011fru kromozom da\u011f\u0131l\u0131m\u0131nda etkili olan \u201ci\u011fipli\u011fi kontrol noktas\u0131\u201d ad\u0131 verilen bir yolak \u00fczerinde yo\u011funla\u015ft\u0131. \u201c\u0130\u011fipli\u011fi kontrol noktas\u0131\u201d kromozomlar\u0131 ay\u0131rmak i\u00e7in protein liflerinin (i\u011fiplikleri) ba\u011fland\u0131\u011f\u0131 kinetekor ad\u0131 verilen kromozomdaki bir b\u00f6lgede etkinle\u015ftirilir. Biliminsanlar\u0131, kinetekorlar bu protein liflerine ba\u011flanmad\u0131\u011f\u0131nda h\u00fccreyi b\u00f6l\u00fcnme s\u0131ras\u0131nda durduran bir \u201cbekleme\u201d sinyali g\u00f6nderilerek ba\u011flant\u0131lar\u0131n olu\u015fmas\u0131 i\u00e7in h\u00fccreye zaman kazand\u0131r\u0131ld\u0131\u011f\u0131n\u0131 s\u00f6yl\u00fcyor. Bu sinyal arac\u0131l\u0131\u011f\u0131yla te\u015fvik edilen s\u00fcre\u00e7lerle birlikte t\u00fcm kromozomlar\u0131n d\u00fczg\u00fcn bir \u015fekilde ba\u011fland\u0131\u011f\u0131ndan, kromozomlar\u0131n do\u011fru bir da\u011f\u0131l\u0131mda oldu\u011fundan emin olunur.<\/p>\n

Makalede ise kontrol noktas\u0131ndaki bekleme sinyalinin ba\u011flanmam\u0131\u015f kromozomlar\u0131n kinetekorlar\u0131nda \u00f6zel olarak nas\u0131l \u00fcretildi\u011fi anlat\u0131l\u0131yor. Ara\u015ft\u0131rmac\u0131lar, canl\u0131 h\u00fccrelerin kinetekorlar\u0131nda bekleme sinyali olu\u015fumundaki molek\u00fcler mekanizmay\u0131 izleyebilmelerini sa\u011flayan bir floresan ara\u015ft\u0131rma arac\u0131 geli\u015ftirdiler. Ara\u015ft\u0131rmac\u0131lar\u0131n a\u00e7\u0131klamalar\u0131na g\u00f6re \u00e7al\u0131\u015fmalar\u0131, bekleme sinyalini kendi ba\u015flar\u0131na etkinle\u015ftirmeyi \u201csevmeyen\u201d iki bile\u015fenin bir araya gelmesini sa\u011flayan anahtar molek\u00fcl\u00fcn varl\u0131\u011f\u0131n\u0131 g\u00f6sterdi. Ayr\u0131ca sonu\u00e7lar, \u201cbekleme\u201d kontrol noktas\u0131 sinyalinin neden h\u00fccrenin ba\u015fka bir b\u00f6lgesinde de\u011fil de kinetekorlarda se\u00e7ici olarak \u00fcretildi\u011fini a\u00e7\u0131klamaya da katk\u0131 sa\u011fl\u0131yor.<\/p>\n

Ara\u015ft\u0131rma ile birlikte kanser gibi h\u00fccre b\u00f6l\u00fcnmesinin kontrol\u00fcn\u00fcn kaybedildi\u011fi hastal\u0131klar i\u00e7in yeni tedavi metotlar\u0131 da geli\u015ftirilebilir.<\/p>\n

Kaynak:<\/strong> https:\/\/phys.org\/news\/2021-01-cell-biologists-decipher-chromosome-left.html<\/p>\n","protected":false},"excerpt":{"rendered":"

\u00c7ok h\u00fccreli organizmalar, tek bir h\u00fccreden k\u00f6ken al\u0131rlar ve sonucunda kemikler, kalp, beyin ve di\u011fer bile\u015fenlerin olu\u015ftu\u011fu milyonlarca h\u00fccre b\u00f6l\u00fcnmesi ya\u015farlar. Bu s\u00fcre\u00e7teki ana kaynak, DNA’n\u0131n kromozom ad\u0131 verilen ayr\u0131 paketler i\u00e7inde h\u00fccre b\u00f6l\u00fcnmesi yoluyla yeni h\u00fccrelere aktar\u0131lmas\u0131d\u0131r. T\u00fcm kromozomlar\u0131n kopyalanmas\u0131 ve her h\u00fccre b\u00f6l\u00fcnmesinde yeni h\u00fccrelere hassas bir \u015fekilde da\u011f\u0131t\u0131lmas\u0131 \u00e7ok \u00f6nemlidir. Kromozom bile\u015fenlerinin […]<\/p>\n","protected":false},"author":1390,"featured_media":48228,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[5350,7246,7248,7247,5191],"class_list":["post-48227","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-hucre-bolunmesi","tag-igipligi","tag-kinetekor","tag-kontrol","tag-sinyal"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t