Beyindeki hasara yan\u0131t olarak n\u00f6ral k\u00f6k h\u00fccreler kendi aras\u0131nda k\u00fcmelenir ve hasardan etkilenen b\u00f6lgeye do\u011fru ilerlerler, g\u00f6\u00e7 ederler. Bu noktada k\u00fcmelenme anahtar roldedir. \u00c7\u00fcnk\u00fc k\u00fcmelenme olmazsa h\u00fccreler g\u00f6\u00e7 etmeye ba\u015flamaz. Peki k\u00f6k h\u00fccrelerin k\u00fcmelenmesinin ana sebebi nedir? Yale \u00dcniversitesi\u2019nden ara\u015ft\u0131rmac\u0131lar, beynin i\u015fleyi\u015finin \u00fc\u00e7 boyutlu bir modelini olu\u015fturarak soruya yan\u0131t arad\u0131.<\/p>\n
FASEB Journal<\/em>\u2019da yay\u0131nlanan \u00e7al\u0131\u015fma hasara yan\u0131t s\u0131ras\u0131nda metaloproteinaz-2 (MMP-2) enziminin oynad\u0131\u011f\u0131 rol\u00fc ilk kez g\u00f6stermektedir. Ara\u015ft\u0131rmac\u0131lar beyin hasar\u0131n\u0131n tedavisinde ilerlemelere yol a\u00e7abilecek \u00e7al\u0131\u015fmalar\u0131nda \u00f6zellikle fel\u00e7ten kaynaklanan beyin hasar\u0131na odakland\u0131lar. \u00c7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131 ise Parkinson, Alzheimer ve di\u011fer n\u00f6rolojik bozukluklar\u0131n tedavisi i\u00e7in de \u00f6nemli noktalar i\u00e7ermektedir.<\/p>\n Beyin hasar\u0131 s\u00f6z konusu oldu\u011funda n\u00f6ral k\u00f6k h\u00fccreler bir araya gelir, toplan\u0131r ve bulunduklar\u0131 subventrik\u00fcler b\u00f6lgeden beynin ilgili k\u0131s\u0131mlar\u0131na do\u011fru g\u00f6\u00e7 ederler. G\u00f6\u00e7\u00fcn y\u00f6n\u00fc endotel h\u00fccrelerinden gelen kimyasal sinyallerle belirlenir. T\u00fcm bu bilgiler bilinmekle birlikte, g\u00f6\u00e7\u00fc ba\u015flatan k\u00fcmelenmeyi neyin ba\u015flatt\u0131\u011f\u0131 bilinmemekteydi: “K\u00fcmelenme etkisine neyin sebep oldu\u011funu bilmek” i\u00e7in yola \u00e7\u0131kan biliminsanlar\u0131 mekanizmalar\u0131 daha iyi g\u00f6rebilmek i\u00e7in \u00e7e\u015fitli modeller kulland\u0131lar. Yaln\u0131zca h\u00fccre g\u00f6\u00e7\u00fcnde de\u011fil, ayn\u0131 zamanda MMP2 salg\u0131layarak k\u00fcmelenmenin te\u015fvik edilmesinde endotel h\u00fccrelerinin i\u015f g\u00f6rd\u00fc\u011f\u00fcn\u00fc ortaya koydular.<\/p>\n “MMP2’yi dokuyu \u00e7evreleyen alan\u0131 bozan bir enzim olarak d\u00fc\u015f\u00fcnebiliriz” diyen biliminsanlar\u0131 normalde bu enzimin k\u00f6k h\u00fccrelerin \u201cyap\u0131\u015faca\u011f\u0131\u201d proteinler oldu\u011funu, ancak bunun yerine MMP2’lerin h\u00fccre k\u00fcmelerinin a\u015fa\u011f\u0131 g\u00f6\u00e7 etmesi i\u00e7in \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131 ifade ediyor. MMP2’nin salg\u0131lanmas\u0131yla birlikte, h\u00fccreler i\u00e7in bir yap\u0131\u015ft\u0131r\u0131c\u0131 g\u00f6revi g\u00f6ren N-kaderin proteininin aktifle\u015ftirildi\u011fi ve b\u00f6ylece n\u00f6ral k\u00f6k h\u00fccrelerin birbirine yap\u0131\u015fmas\u0131na ve k\u00fcmelenmesine neden olan kol benzeri uzant\u0131lar\u0131n geli\u015fimini sa\u011flad\u0131\u011f\u0131 raporland\u0131.<\/p>\n Ara\u015ft\u0131rmac\u0131lar, ara\u015ft\u0131rmadan elde edilen verilerle, hasar g\u00f6rm\u00fc\u015f ve bozuk dokular\u0131n onar\u0131m\u0131nda i\u015flevli yeni terap\u00f6tik (tedavi odakl\u0131) stratejiler geli\u015ftirilebilece\u011fi g\u00f6r\u00fc\u015f\u00fcnde.<\/p>\n Kaynak:<\/strong> https:\/\/medicalxpress.com\/news\/2021-03-insight-brain-response-injury.html<\/p>\n","protected":false},"excerpt":{"rendered":" Beyindeki hasara yan\u0131t olarak n\u00f6ral k\u00f6k h\u00fccreler kendi aras\u0131nda k\u00fcmelenir ve hasardan etkilenen b\u00f6lgeye do\u011fru ilerlerler, g\u00f6\u00e7 ederler. Bu noktada k\u00fcmelenme anahtar roldedir. \u00c7\u00fcnk\u00fc k\u00fcmelenme olmazsa h\u00fccreler g\u00f6\u00e7 etmeye ba\u015flamaz. Peki k\u00f6k h\u00fccrelerin k\u00fcmelenmesinin ana sebebi nedir? Yale \u00dcniversitesi\u2019nden ara\u015ft\u0131rmac\u0131lar, beynin i\u015fleyi\u015finin \u00fc\u00e7 boyutlu bir modelini olu\u015fturarak soruya yan\u0131t arad\u0131. FASEB Journal\u2019da yay\u0131nlanan \u00e7al\u0131\u015fma hasara […]<\/p>\n","protected":false},"author":1390,"featured_media":47419,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[254,5345,6646,1171,7406],"class_list":["post-49033","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-beyin","tag-enzim","tag-hasar","tag-protein","tag-yanit"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t