{"id":49128,"date":"2021-03-17T11:25:10","date_gmt":"2021-03-17T08:25:10","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=49128"},"modified":"2021-03-17T11:25:10","modified_gmt":"2021-03-17T08:25:10","slug":"bagisiklik-sisteminin-onemli-elemanlarindan-dogal-oldurucu-hucreler-nasil-farklilasir","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2021\/03\/17\/bagisiklik-sisteminin-onemli-elemanlarindan-dogal-oldurucu-hucreler-nasil-farklilasir","title":{"rendered":"Ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin \u00f6nemli elemanlar\u0131ndan do\u011fal \u00f6ld\u00fcr\u00fcc\u00fc h\u00fccreler nas\u0131l farkl\u0131la\u015f\u0131r?"},"content":{"rendered":"<p>Ara\u015ft\u0131rmac\u0131lar, do\u011fal \u00f6ld\u00fcr\u00fcc\u00fc h\u00fccreler veya do\u011fal katil h\u00fccreleri (natural killer (NK) cells) olarak bilinen ba\u011f\u0131\u015f\u0131kl\u0131k sistemi elemanlar\u0131n\u0131n farkl\u0131la\u015fmas\u0131nda kritik bir rol oynayan geni tespit etti.<em> Science Immunology<\/em> dergisinde yay\u0131nlanan makalede ekip, do\u011fal \u00f6ld\u00fcr\u00fcc\u00fc h\u00fccrelerin transkripsiyonel (protein \u00fcretim, gen anlat\u0131m s\u00fcreci) ve epigenetik (gen anlat\u0131m\u0131na \u00e7evrenin etkisi) profilini \u00e7\u0131kard\u0131. Ara\u015ft\u0131rmac\u0131lar ayn\u0131 zamanda do\u011fal \u00f6ld\u00fcr\u00fcc\u00fc h\u00fccrelerin ba\u011f\u0131\u015f\u0131kl\u0131k sisteminde oynad\u0131\u011f\u0131 rol\u00fc de makalelerinde tart\u0131\u015f\u0131yor.<\/p>\n<p>Do\u011fal \u00f6ld\u00fcr\u00fcc\u00fc (NK) h\u00fccreler, ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin \u00e7ok \u00f6nemli bir par\u00e7as\u0131d\u0131r. Vir\u00fcs kaynakl\u0131 enfeksiyonlar ve kanser geli\u015fimi gibi durumlara ba\u011f\u0131\u015f\u0131kl\u0131k yan\u0131t\u0131 verilmesinde kritik bir rol oynarlar. Ara\u015ft\u0131rmac\u0131lar do\u011fal \u00f6ld\u00fcr\u00fcc\u00fc h\u00fccrelerin nas\u0131l farkl\u0131la\u015ft\u0131\u011f\u0131n\u0131 daha iyi anlamaya \u00e7al\u0131\u015ft\u0131. Ara\u015ft\u0131rma s\u0131ras\u0131nda do\u011fal \u00f6ld\u00fcr\u00fcc\u00fc h\u00fccrelerin ba\u011f\u0131\u015f\u0131kl\u0131k yan\u0131t\u0131nda daha spesifik roller oynamas\u0131na olanak sa\u011flayan bir gen anlat\u0131m\u0131 de\u011fi\u015fikli\u011fine u\u011frad\u0131\u011f\u0131 g\u00f6r\u00fcld\u00fc.<\/p>\n<p>Do\u011fal \u00f6ld\u00fcr\u00fcc\u00fc h\u00fccrelerin i\u015flev g\u00f6rebilmesi i\u00e7in \u00e7e\u015fitli fakt\u00f6rlerin (inhibit\u00f6rler, resept\u00f6rler) bir araya gelmesi gerekir. Bu nedenle NK h\u00fccrelerinin i\u015flevi, di\u011fer h\u00fccrelerden ald\u0131klar\u0131 sinyallere ba\u011fl\u0131d\u0131r. Ara\u015ft\u0131rma bu duruma ek olarak NK h\u00fccrelerinin i\u015flevinin, fakl\u0131la\u015fmalar\u0131na da ba\u011fl\u0131 oldu\u011funu g\u00f6sterdi. Farkl\u0131la\u015fman\u0131n ger\u00e7ekle\u015febilmesi i\u00e7in h\u00fccrelerin \u00f6zelliklerini ve farkl\u0131la\u015fma s\u00fcrecini kontrol eden h\u00fccre i\u00e7i mekanizmalar olmal\u0131d\u0131r. Bu mekanizmalar ise genetik materyalimizde ve onun i\u015flenme s\u00fcrecinde sakl\u0131d\u0131r. Ara\u015ft\u0131rmac\u0131lar mekanizmalar\u0131 daha iyi anlamak i\u00e7in epigenetik ve transkripsiyonel \u00e7al\u0131\u015fmalar y\u00fcr\u00fctt\u00fc.<\/p>\n<p>Epigenetik, genetik materyalde dizi de\u011fi\u015fikli\u011fi olmaks\u0131z\u0131n, \u00e7evreden gelen baz\u0131 kimyasallar etkisiyle (Asetillenme, metillenme, deasetillenme,\u2026) gen anlat\u0131m\u0131n\u0131n de\u011fi\u015fmesi, dolay\u0131s\u0131yla \u00fcretilen protein yap\u0131lar\u0131n\u0131n fonksiyonunun ve etki etme bi\u00e7imlerinin de\u011fi\u015fmesi olarak nitelendirilir. Bu durum \u00e7evrenin metabolizmam\u0131z \u00fczerindeki etkisini g\u00f6stermektedir. Transkripsiyon ise, gen anlat\u0131m s\u00fcrecinin (protein \u00fcretimi) ba\u015flat\u0131c\u0131 unsurudur. Ara\u015ft\u0131rmac\u0131lar, NK h\u00fccrelerinin farkl\u0131la\u015fma s\u00fcrecinin Bcl11b adl\u0131 bir transkripsiyon fakt\u00f6r\u00fc taraf\u0131ndan kontrol edildi\u011fini tespit etti. Ayr\u0131ca mutasyon nedeniyle Bcl11b&#8217;de ger\u00e7ekle\u015fen ifade kayb\u0131n\u0131n NK h\u00fccrelerinde fonksiyon kayb\u0131na neden oldu\u011fu da raporlanm\u0131\u015ft\u0131r.<\/p>\n<p>Biliminsanlar\u0131 NK h\u00fccrelerinin i\u015flevinin ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin bir di\u011fer \u00f6nemli eleman\u0131 olan T h\u00fccrelerinin i\u015flevini tamamlay\u0131c\u0131 bir role sahip oldu\u011funa da ifade ediyor. Bulgular\u0131n, ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin \u00e7al\u0131\u015fma bi\u00e7iminin daha iyi anla\u015f\u0131lmas\u0131na yarar sa\u011flayaca\u011f\u0131 d\u00fc\u015f\u00fcn\u00fclmektedir.<\/p>\n<p><strong>Kaynak:<\/strong> https:\/\/medicalxpress.com\/news\/2021-03-gene-critical-role-natural-killer.html<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ara\u015ft\u0131rmac\u0131lar, do\u011fal \u00f6ld\u00fcr\u00fcc\u00fc h\u00fccreler veya do\u011fal katil h\u00fccreleri (natural killer (NK) cells) olarak bilinen ba\u011f\u0131\u015f\u0131kl\u0131k sistemi elemanlar\u0131n\u0131n farkl\u0131la\u015fmas\u0131nda kritik bir rol oynayan geni tespit etti. Science Immunology dergisinde yay\u0131nlanan makalede ekip, do\u011fal \u00f6ld\u00fcr\u00fcc\u00fc h\u00fccrelerin transkripsiyonel (protein \u00fcretim, gen anlat\u0131m s\u00fcreci) ve epigenetik (gen anlat\u0131m\u0131na \u00e7evrenin etkisi) profilini \u00e7\u0131kard\u0131. Ara\u015ft\u0131rmac\u0131lar ayn\u0131 zamanda do\u011fal \u00f6ld\u00fcr\u00fcc\u00fc h\u00fccrelerin ba\u011f\u0131\u015f\u0131kl\u0131k [&hellip;]<\/p>\n","protected":false},"author":1390,"featured_media":49129,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[2413,7430,2114,7431],"class_list":["post-49128","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-bagisiklik-sistemi","tag-dogal-oldurucu-hucreler","tag-epigenetik","tag-farklilasma"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/49128","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1390"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=49128"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/49128\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media\/49129"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=49128"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=49128"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=49128"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}