{"id":49778,"date":"2021-04-06T10:43:37","date_gmt":"2021-04-06T07:43:37","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=49778"},"modified":"2021-04-06T10:44:08","modified_gmt":"2021-04-06T07:44:08","slug":"disler-sogugu-nasil-algilar","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2021\/04\/06\/disler-sogugu-nasil-algilar","title":{"rendered":"Di\u015fler so\u011fu\u011fu nas\u0131l alg\u0131lar?"},"content":{"rendered":"<p>So\u011fuk, di\u015flerde ve di\u015f etlerinde ciddi bir a\u011fr\u0131ya neden olur, \u00f6zellikle de \u00e7\u00fcr\u00fcm\u00fc\u015flerse&#8230;<\/p>\n<p><em>Science Advences<\/em> portal\u0131nda yay\u0131mlanan bir \u00e7al\u0131\u015fmada, bilim insanlar\u0131, di\u015flerde so\u011fu\u011fa hassasiyete yol a\u00e7an bir proteini analiz etti. TRPC5 proteini asl\u0131nda bir iyon kanal\u0131d\u0131r: A\u00e7\u0131l\u0131p kapanarak iyonlar\u0131n ge\u00e7i\u015fini sa\u011flayan bir molek\u00fcler ge\u00e7it borusu gibi d\u00fc\u015f\u00fcn\u00fclebilir. Bu durumun v\u00fccudun pek \u00e7ok b\u00f6l\u00fcm\u00fcnde de olu\u015ftu\u011funu, 15 y\u0131ld\u0131r deri \u00fczerine \u00e7al\u0131\u015fma yapan US Medical Enstit\u00fc\u2019den Howard Huges da daha \u00f6nce belirtmi\u015fti. Ara\u015ft\u0131rmac\u0131lara g\u00f6re bu protein so\u011fu\u011fa epeyce duyarl\u0131 fakat herhangi bir fiziksel yan\u0131ttan sorumlu de\u011fil. 2011\u2019de yay\u0131mlanan bir makalede, derilerinde bu proteini olmayan farelerin art\u0131k so\u011fu\u011fu hissedemedikleri belirtilmi\u015fti.<\/p>\n<p>Almanya Friedrich-Alexander \u00dcniversitesi\u2019nde elektrofizyolog olarak \u00e7al\u0131\u015fan ara\u015ft\u0131rmac\u0131 Katharina Zimmerman ve n\u00f6robiyolog David Clapham, \u201cO s\u0131ralarda bir \u00e7\u0131kmaza girmi\u015ftik\u201d diyorlar. Konunun \u00fczerinde tekrar d\u00fc\u015f\u00fcnd\u00fck\u00e7e ve bir \u00f6\u011flen yeme\u011finde David \u201cV\u00fccutta ba\u015fka hangi b\u00f6l\u00fcmler so\u011fu\u011fa \u00e7ok hassast\u0131r\u201d diye sorunca di\u015fler \u00fczerinde \u00e7al\u0131\u015fmak ak\u0131llar\u0131na gelmi\u015f. Yapt\u0131klar\u0131 yeni \u00e7al\u0131\u015fmada TRPC5 proteininin di\u015flerde bulundu\u011funu ve sinirlerle ba\u011flant\u0131l\u0131 oldu\u011funu g\u00f6sterdiler. Protein, odontoblast ad\u0131 verilen ve normalde gayet iyi korunurken \u00e7\u00fcr\u00fcm\u00fc\u015f di\u015flerde a\u00e7\u0131\u011fa \u00e7\u0131kan h\u00fccrelerde g\u00f6r\u00fcld\u00fc.<\/p>\n<p>Ekip, di\u015flerinde TRPC5 olmayan farelerle birlikte bu proteinin kimyasal maddelerle bloke edildi\u011fi fareler \u00fczerinde \u00e7al\u0131\u015ft\u0131lar.<br \/>\nKontrol gurubu farelerde, buzlu bir s\u0131v\u0131yla di\u015fler temas ettirildi\u011finde sinir yan\u0131t\u0131n\u0131n uyar\u0131ld\u0131\u011f\u0131 g\u00f6zlendi. Burada bir di\u011fer protein olan TRPA1\u2019in de ayn\u0131 \u015fekilde etkili olabilece\u011fi d\u00fc\u015f\u00fcn\u00fcld\u00fc. Ancak proteinsiz olanlar ve kimyasal olarak yok edilenlerde herhangi bir sinirsel yan\u0131t uyar\u0131lmam\u0131\u015ft\u0131.<\/p>\n<p>Ara\u015ft\u0131rmac\u0131lar ayr\u0131ca, y\u00fczlerce y\u0131ld\u0131r di\u015f a\u011fr\u0131s\u0131 i\u00e7in kullan\u0131lan karanfil ya\u011f\u0131n\u0131n da neden etkili oldu\u011funu a\u00e7\u0131klad\u0131lar. Karanfil ya\u011f\u0131, TRPC5 proteinini bloke eden bir kimyasal i\u00e7eriyordu. Bu da sinirsel uyar\u0131y\u0131 engelliyor ve dolay\u0131s\u0131yla a\u011fr\u0131y\u0131 kesiyordu. Zimmerman, \u201dHer bir molek\u00fcl\u00fcn ke\u015ffi, bizi o konudaki bir tedaviye daha da yakla\u015ft\u0131r\u0131yor\u201d diyerek gelecekte di\u015f a\u011fr\u0131lar\u0131n\u0131n tedavisinde h\u0131zl\u0131 ad\u0131mlar at\u0131labilece\u011finin m\u00fcjdesini veriyor.<\/p>\n<p><strong>Kaynak:<\/strong> https:\/\/cosmosmagazine.com\/science\/biology\/how-teeth-sense-cold-temperatures\/<\/p>\n","protected":false},"excerpt":{"rendered":"<p>So\u011fuk, di\u015flerde ve di\u015f etlerinde ciddi bir a\u011fr\u0131ya neden olur, \u00f6zellikle de \u00e7\u00fcr\u00fcm\u00fc\u015flerse&#8230; Science Advences portal\u0131nda yay\u0131mlanan bir \u00e7al\u0131\u015fmada, bilim insanlar\u0131, di\u015flerde so\u011fu\u011fa hassasiyete yol a\u00e7an bir proteini analiz etti. TRPC5 proteini asl\u0131nda bir iyon kanal\u0131d\u0131r: A\u00e7\u0131l\u0131p kapanarak iyonlar\u0131n ge\u00e7i\u015fini sa\u011flayan bir molek\u00fcler ge\u00e7it borusu gibi d\u00fc\u015f\u00fcn\u00fclebilir. Bu durumun v\u00fccudun pek \u00e7ok b\u00f6l\u00fcm\u00fcnde de olu\u015ftu\u011funu, [&hellip;]<\/p>\n","protected":false},"author":42,"featured_media":49779,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19,5231],"tags":[1488,1642,1171,7598],"class_list":["post-49778","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","category-merak-ettikleriniz","tag-dis","tag-molekul","tag-protein","tag-soguk"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/49778","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/42"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=49778"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/49778\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media\/49779"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=49778"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=49778"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=49778"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}