Antibiyotik direnci insan sa\u011fl\u0131\u011f\u0131 i\u00e7in ciddi bir tehdittir. Diren\u00e7li patojenlerden kaynaklanan enfeksiyonlar y\u0131lda 750 binden fazla insan\u0131n \u00f6l\u00fcm\u00fcne neden olmaktad\u0131r. Direncin ortaya \u00e7\u0131kmas\u0131nda ise hastalar\u0131n antibiyotiklerle tedavi edilmesi etkilidir. Fakat enfeksiyonlar s\u0131ras\u0131nda direncin nas\u0131l ortaya \u00e7\u0131kt\u0131\u011f\u0131 tam olarak anla\u015f\u0131lamam\u0131\u015ft\u0131r.<\/p>\n
Nature Communications<\/em> portal\u0131nda yay\u0131nlanan yeni \u00e7al\u0131\u015fmaya g\u00f6re bakterilerin h\u0131zl\u0131 evrim s\u00fcreci, bakterilerin enfeksiyon s\u0131ras\u0131nda antibiyoti\u011fe kar\u015f\u0131 diren\u00e7teki de\u011fi\u015fimi (art\u0131\u015f ve\/veya azal\u0131\u015f) \u015fekillendirmek i\u00e7in konak organizman\u0131n ba\u011f\u0131\u015f\u0131kl\u0131k sistemi ile de ili\u015fkilendi\u011fini g\u00f6stermektedir.<\/p>\n \u00c7al\u0131\u015fma, ba\u011f\u0131\u015f\u0131k sistemimizin bakteriyel enfeksiyonlar ile m\u00fccadele etmek i\u00e7in antibiyotikleri nas\u0131l kulland\u0131\u011f\u0131na odaklanmaktad\u0131r. Oxford \u00dcniversitesi’nden Prof. Craig MacLean, \u201c\u00c7al\u0131\u015fmam\u0131z do\u011fal ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131n enfeksiyon s\u0131ras\u0131nda direnci \u00f6nleyebilece\u011fini ve diren\u00e7li su\u015flar\u0131n hastalar aras\u0131nda ge\u00e7i\u015fi durdurabilece\u011fini g\u00f6steriyor. Bu ba\u011flant\u0131dan yararlanarak yeni tedaviler geli\u015ftirebiliriz\u201d a\u00e7\u0131klamalar\u0131nda bulundu.<\/p>\n Ara\u015ft\u0131rmac\u0131lar, antibiyotik tedavisinin enfeksiyona kaynakl\u0131k eden bakterilerin b\u00fcy\u00fck bir k\u0131sm\u0131n\u0131 \u00f6ld\u00fcrd\u00fc\u011f\u00fcn\u00fc ancak diren\u00e7li mutasyonlar\u0131 ta\u015f\u0131yan bakterilerin tedavi s\u0131ras\u0131nda b\u00fcy\u00fcmeye ve \u00e7o\u011falmaya devam etti\u011fini g\u00f6zlemlediler. Ayn\u0131 zamanda diren\u00e7li mutantlar\u0131n d\u00fc\u015f\u00fck rekabet kabiliyetinde oldu\u011fu ve antibiyotik tedavisinden ka\u00e7abilen t\u00fcrler bu mutantlar oldu\u011fundan tedavi sonras\u0131nda toplam direncin azald\u0131\u011f\u0131n\u0131 g\u00f6sterdiler. MacLean, “Enfeksiyon s\u00fcrecinde direncin hem y\u00fckselmesi hem de d\u00fc\u015fmesi, do\u011fal se\u00e7ilim yoluyla evrimin basit ve zarif \u00f6rnekleridir” dedi.<\/p>\n Bu durumda konak\u00e7\u0131 ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131n\u0131n etkili oldu\u011fu d\u00fc\u015f\u00fcn\u00fclmektedir. Konak\u00e7\u0131 ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 enfeksiyonun bask\u0131lanmas\u0131na yard\u0131mc\u0131 oluyordu ve antibiyotik tedavisinin ba\u015flang\u0131c\u0131nda var olan diren\u00e7li mutantlar\u0131n y\u00fczde 90’\u0131ndan fazlas\u0131n\u0131n ortadan kald\u0131r\u0131lmas\u0131nda etkiliydi. Konak\u00e7\u0131 ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131, tedaviden sonra mevcut olan diren\u00e7li pop\u00fclasyonlar \u00fczerinde de etkili oluyordu.<\/p>\n Biliminsanlar\u0131, bakteri pop\u00fclasyonundaki de\u011fi\u015fikleri y\u00fcksek \u00e7\u00f6z\u00fcn\u00fcrl\u00fck d\u00fczeyinde belirleyerek ve bulgular\u0131, ba\u011f\u0131\u015f\u0131kl\u0131k ile ilgili bilgilerle birle\u015ftirerek yeni verilerin elde edilmesini sa\u011flad\u0131. \u00c7al\u0131\u015fmada kistik fibroz ve bron\u015fektazili gibi hastal\u0131klara neden olan Pseudomonas aeruginosa patojeni \u00fczerinde duruldu.<\/p>\n Ara\u015ft\u0131rmac\u0131lar t\u0131p alan\u0131ndaki bu sorunun \u00e7\u00f6z\u00fcm\u00fcnde evrimden yararlan\u0131lmas\u0131n\u0131 ba\u015far\u0131lar\u0131n\u0131n ger\u00e7ek anahtar\u0131 olarak g\u00f6rmekte.<\/p>\n Kaynak: https:\/\/phys.org\/news\/2021-04-rapid-evolution-host-immunity-fall.html<\/p>\n","protected":false},"excerpt":{"rendered":" Antibiyotik direnci insan sa\u011fl\u0131\u011f\u0131 i\u00e7in ciddi bir tehdittir. Diren\u00e7li patojenlerden kaynaklanan enfeksiyonlar y\u0131lda 750 binden fazla insan\u0131n \u00f6l\u00fcm\u00fcne neden olmaktad\u0131r. Direncin ortaya \u00e7\u0131kmas\u0131nda ise hastalar\u0131n antibiyotiklerle tedavi edilmesi etkilidir. Fakat enfeksiyonlar s\u0131ras\u0131nda direncin nas\u0131l ortaya \u00e7\u0131kt\u0131\u011f\u0131 tam olarak anla\u015f\u0131lamam\u0131\u015ft\u0131r. Nature Communications portal\u0131nda yay\u0131nlanan yeni \u00e7al\u0131\u015fmaya g\u00f6re bakterilerin h\u0131zl\u0131 evrim s\u00fcreci, bakterilerin enfeksiyon s\u0131ras\u0131nda antibiyoti\u011fe kar\u015f\u0131 […]<\/p>\n","protected":false},"author":1390,"featured_media":50214,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[4489,493,1875,200],"class_list":["post-50213","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-antibiyotik-direnci","tag-bakteri","tag-enfeksiyon","tag-evrim"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/50213","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1390"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=50213"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/50213\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media\/50214"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=50213"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=50213"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=50213"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}