Ara\u015ft\u0131rmac\u0131lar yeni \u00e7al\u0131\u015fmalar\u0131nda, g\u00f6rme engelli bir ki\u015fide g\u00f6r\u00fc\u015f\u00fcn yeniden sa\u011flanmas\u0131 i\u00e7in ilk kez bir t\u00fcr gen terapi kulland\u0131. Ekip, \u0131\u015f\u0131\u011f\u0131 emen ve beyin sinyallerine d\u00f6n\u00fc\u015ft\u00fcren h\u00fccreleri par\u00e7alayan genetik bir bozukluk olan retinitis pigmentosa taraf\u0131ndan g\u00f6r\u00fc\u015f\u00fc bozulan bir ki\u015finin retina ganglion h\u00fccrelerini \u0131\u015f\u0131\u011fa duyarl\u0131 hale getirmek i\u00e7in onlar\u0131 genetik olarak de\u011fi\u015ftirdi.<\/p>\n
Nature Medicine<\/em>\u2019da yay\u0131nlanan \u00e7al\u0131\u015fmada, gen terapi uygulanan ki\u015finin \u00f6zel bir g\u00f6zl\u00fck yard\u0131m\u0131yla b\u00fcy\u00fck bir defteri, k\u00fc\u00e7\u00fck bir z\u0131mba kutusunu, cam bardaklar\u0131 ve yaya ge\u00e7idinin \u015feritlerini alg\u0131layabildi\u011fi kaydedildi. Ara\u015ft\u0131rma, optogenetik tedavi yoluyla iyile\u015fme g\u00f6zlenen ilk vakay\u0131 bildirmesi nedeniyle \u00f6nemli bir yerde duruyor.<\/p>\n \u0130nsan retinas\u0131n\u0131n yap\u0131s\u0131na yak\u0131ndan bakt\u0131\u011f\u0131m\u0131zda \u0131\u015f\u0131\u011f\u0131 alg\u0131layan fotoresept\u00f6rlerin retinan\u0131n en gerisinde oldu\u011funu g\u00f6r\u00fcr\u00fcz. Bunun yan\u0131 s\u0131ra gangliyon h\u00fccreleri, optik sinir yoluyla fotoresept\u00f6rlerden beyne g\u00f6rsel bilgi iletir. Retina hasar\u0131n\u0131 i\u00e7eren ve g\u00f6rme kayb\u0131na neden olan hastal\u0131klar i\u00e7in potansiyel bir tedavi y\u00f6ntemi olabilece\u011fi bildirilen optogenetikte ise h\u00fccreler genetik olarak de\u011fi\u015ftirilir ve \u00f6zel bir \u0131\u015f\u0131\u011fa duyarl\u0131 proteini (channelrhodopsin) \u00fcretmeye ba\u015flarlar.<\/p>\n \u00c7al\u0131\u015fmada, retinan\u0131n genetik de\u011fi\u015fikli\u011fe uyum sa\u011flamas\u0131 i\u00e7in be\u015f ay beklendikten sonra ki\u015fiye belirli \u0131\u015f\u0131k dalga boylar\u0131ndaki g\u00f6r\u00fcnt\u00fcleri retinay\u0131 yans\u0131tan \u00f6zel bir g\u00f6zl\u00fc verildi. Yedi ayl\u0131k e\u011fitimin ard\u0131ndan ki\u015finin g\u00f6r\u00fc\u015f\u00fcnde iyile\u015fme belirtileri g\u00f6zlendi.<\/p>\n Beyindeki elektriksel aktiviteyi de inceleyen biliminsanlar\u0131, elektroensefalogram (EEG) okumas\u0131 ile, tedavi edilen ki\u015finin beyninin ger\u00e7ekten de g\u00f6zden gelen g\u00f6rsel girdiye yan\u0131t verdi\u011fini g\u00f6rd\u00fc. Fakat ara\u015ft\u0131rmac\u0131lar tedavi edilen ki\u015finin y\u00fczleri tan\u0131yabilecek kadar iyile\u015fmesinin beklenmedi\u011fini belirtiyor. \u00c7\u00fcnk\u00fc y\u00fczleri tan\u0131mak i\u00e7in \u00e7ok y\u00fcksek \u00e7\u00f6z\u00fcn\u00fcrl\u00fc\u011fe ihtiya\u00e7 vard\u0131r.<\/p>\n Asl\u0131nda \u00e7al\u0131\u015fma daha fazla kat\u0131l\u0131mc\u0131y\u0131 i\u00e7ermektedir. Fakat COVID-19 k\u00fcresel salg\u0131n\u0131 nedeniyle kat\u0131l\u0131mc\u0131lar \u00f6zel g\u00f6zl\u00fcklerle e\u011fitim alabilecekleri t\u0131p merkezlerine gidemedi. Ara\u015ft\u0131rmac\u0131lar \u00e7al\u0131\u015fman\u0131n \u00f6nemi bir kez daha vurgularken, gen terapinin g\u00f6rme kayb\u0131 olan di\u011fer insanlarda da i\u015fe yaray\u0131p yaramayaca\u011f\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131 gerekti\u011fini belirtiyor.<\/p>\n Kaynak:<\/strong> https:\/\/medicalxpress.com\/news\/2021-05-years-regains-sight-gene-therapy.html<\/p>\n","protected":false},"excerpt":{"rendered":" Ara\u015ft\u0131rmac\u0131lar yeni \u00e7al\u0131\u015fmalar\u0131nda, g\u00f6rme engelli bir ki\u015fide g\u00f6r\u00fc\u015f\u00fcn yeniden sa\u011flanmas\u0131 i\u00e7in ilk kez bir t\u00fcr gen terapi kulland\u0131. Ekip, \u0131\u015f\u0131\u011f\u0131 emen ve beyin sinyallerine d\u00f6n\u00fc\u015ft\u00fcren h\u00fccreleri par\u00e7alayan genetik bir bozukluk olan retinitis pigmentosa taraf\u0131ndan g\u00f6r\u00fc\u015f\u00fc bozulan bir ki\u015finin retina ganglion h\u00fccrelerini \u0131\u015f\u0131\u011fa duyarl\u0131 hale getirmek i\u00e7in onlar\u0131 genetik olarak de\u011fi\u015ftirdi. Nature Medicine\u2019da yay\u0131nlanan \u00e7al\u0131\u015fmada, gen […]<\/p>\n","protected":false},"author":1390,"featured_media":36520,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[7705,7561,6795,6838],"class_list":["post-50363","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-fotoreseptor","tag-gen-terapi","tag-gorme-kaybi","tag-optogenetik"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t