Maj\u00f6r depresif bozukluk ve travma sonras\u0131 stres bozuklu\u011fu gibi durumlar da dahil olmak \u00fczere stresle ili\u015fkili psikiyatrik bozukluklar\u0131n arka plan\u0131ndaki biyolojik mekanizmalar b\u00fct\u00fcn\u00fcyle anla\u015f\u0131lamam\u0131\u015ft\u0131r.<\/p>\n
Konuyla ilgili yeni ara\u015ft\u0131rmalarda, v\u00fccudun strese kar\u015f\u0131 tepkisini kontrol etmeye yard\u0131mc\u0131 olan proteinler aras\u0131ndaki etkile\u015fim detayland\u0131r\u0131l\u0131yor ve bu tepki farkl\u0131la\u015ft\u0131\u011f\u0131nda kullan\u0131labilecek potansiyel tedaviler \u00fczerinde \u00e7al\u0131\u015f\u0131l\u0131yor.<\/p>\n
Cell Reports<\/em> dergisinde yay\u0131nlanan \u00e7al\u0131\u015fman\u0131n ba\u015fyazar\u0131 Jakob Hartmann, \u201cV\u00fccudun d\u00fczensiz stres tepkisi beyne zarar verebilir, bu durumda duygu durum ve kayg\u0131 ile ili\u015fkili bozukluklara yatk\u0131nl\u0131k artabilir. Stres tepkisinin d\u00fczenlenmesinde rol oynayan beyin b\u00f6lgesi hipokampustur. Bu \u00e7al\u0131\u015fmayla birlikte, \u00fc\u00e7 \u00f6nemli stres d\u00fczenleyici proteinin hipokampusteki yerle\u015fiminde meydana gelen farkl\u0131la\u015fmay\u0131 g\u00f6rebildik\u201d a\u00e7\u0131klamalar\u0131nda bulundu.<\/p>\n Ara\u015ft\u0131rmac\u0131lar\u0131n dikkat \u00e7ekti\u011fi d\u00fczenleyici proteinler olan glukokortikoid resept\u00f6r\u00fc (GR), mineralokortikoid resept\u00f6r\u00fc (MR) ve FK506 ba\u011flay\u0131c\u0131 protein 51\u2019in (FKBP5) birbirleri ile nas\u0131l etkile\u015fime girdikleri deneysel olarak ara\u015ft\u0131r\u0131ld\u0131.<\/p>\n FKBP5 proteininin \u00fcretimi normal ko\u015fullar alt\u0131nda MR\u2019ler taraf\u0131ndan kontrol edilmektedir. Stres alt\u0131nda FKBP5 proteinleri, GR\u2019lerin stresle ili\u015fkili hormonlara ba\u011flanma duyarl\u0131l\u0131\u011f\u0131n\u0131 azalt\u0131r. Ara\u015ft\u0131rmadan elde edilen bu veri, FKBP5 proteinlerinin hipokampustaki MR-GR dengesinde bir arac\u0131 g\u00f6revi g\u00f6rerek stres tepkisini ayarlad\u0131\u011f\u0131na i\u015faret etmektedir.<\/p>\n \u00c7al\u0131\u015fmada yer alan Kerry J. Ressler, \u201cGR, MR ve FKBP5 proteinlerinin tedavi i\u00e7in yeni hedefler olarak belirlenmesi, stresin merkezi ve \u00e7evresel d\u00fczenlenmesini y\u00f6nlendirmede tamamlay\u0131c\u0131 bir role sahip olabilir. Ayr\u0131ca verilerimiz, stresle ili\u015fkili psikiyatrik bozukluklarda MR sinyalinin \u00f6nemli fakat \u015fimdiye kadar vurgulanmamam\u0131\u015f rol\u00fcne de dikkat \u00e7ekiyor. \u00c7al\u0131\u015fman\u0131n bulgular\u0131, gelecekteki ara\u015ft\u0131rmalar i\u00e7in yeni istikametler sa\u011flayacak\u201d a\u00e7\u0131klamalar\u0131nda bulundu.<\/p>\n Kaynak:<\/strong> https:\/\/medicalxpress.com\/news\/2021-06-uncovers-body-response-stress.html<\/p>\n","protected":false},"excerpt":{"rendered":" Maj\u00f6r depresif bozukluk ve travma sonras\u0131 stres bozuklu\u011fu gibi durumlar da dahil olmak \u00fczere stresle ili\u015fkili psikiyatrik bozukluklar\u0131n arka plan\u0131ndaki biyolojik mekanizmalar b\u00fct\u00fcn\u00fcyle anla\u015f\u0131lamam\u0131\u015ft\u0131r. Konuyla ilgili yeni ara\u015ft\u0131rmalarda, v\u00fccudun strese kar\u015f\u0131 tepkisini kontrol etmeye yard\u0131mc\u0131 olan proteinler aras\u0131ndaki etkile\u015fim detayland\u0131r\u0131l\u0131yor ve bu tepki farkl\u0131la\u015ft\u0131\u011f\u0131nda kullan\u0131labilecek potansiyel tedaviler \u00fczerinde \u00e7al\u0131\u015f\u0131l\u0131yor. Cell Reports dergisinde yay\u0131nlanan \u00e7al\u0131\u015fman\u0131n ba\u015fyazar\u0131 […]<\/p>\n","protected":false},"author":1390,"featured_media":47419,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[2444,1171,429,902],"class_list":["post-50656","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-hipokampus","tag-protein","tag-psikiyatri","tag-stres"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/50656","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1390"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=50656"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/50656\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media\/47419"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=50656"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=50656"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=50656"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}