{"id":50672,"date":"2021-06-24T11:42:12","date_gmt":"2021-06-24T08:42:12","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=50672"},"modified":"2021-06-24T11:42:12","modified_gmt":"2021-06-24T08:42:12","slug":"tumorler-ilaclara-direncli-hale-nasil-gelir","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2021\/06\/24\/tumorler-ilaclara-direncli-hale-nasil-gelir","title":{"rendered":"T\u00fcm\u00f6rler ila\u00e7lara diren\u00e7li hale nas\u0131l gelir?"},"content":{"rendered":"

Yeni \u00e7al\u0131\u015fma, belirli bir proteini hedefleyen kanser ila\u00e7lar\u0131na kar\u015f\u0131 t\u00fcm\u00f6rlerin nas\u0131l diren\u00e7 geli\u015ftirdi\u011fini a\u00e7\u0131kl\u0131yor. Ara\u015ft\u0131rmac\u0131lar, \u00e7al\u0131\u015fmalar\u0131nda, KRASG12C proteinini hedefleyen ila\u00e7lara diren\u00e7li hale gelen t\u00fcm\u00f6rlerin genomik yap\u0131lar\u0131n\u0131 anlamaya odakland\u0131.<\/p>\n

Ara\u015ft\u0131rma, bu tipteki t\u00fcm\u00f6rlerin diren\u00e7 geli\u015fimi i\u00e7in ortak bir yoldan ziyade farkl\u0131 yolaklar\u0131 kulland\u0131\u011f\u0131n\u0131 g\u00f6stermektedir. New England Journal of Medicine<\/em>‘da yay\u0131nlanan \u00e7al\u0131\u015fma, KRASG12C proteinini i\u015flevsiz hale getiren t\u00fcm\u00f6rlerle m\u00fccadele i\u00e7in yeni ila\u00e7lar\u0131n tasarlanmas\u0131 gerekti\u011fini vurgulamaktad\u0131r. Diren\u00e7 geli\u015fimine etki eden mekanizmalardaki \u00e7e\u015fitlilik, s\u00f6z konusu kanser tipleri i\u00e7in ila\u00e7 tasar\u0131mlar\u0131n\u0131n da \u00e7e\u015fitlenmesi gerekti\u011fini g\u00f6stermektedir.<\/p>\n

KRASG12C proteinini \u00fcreten KRAS genindeki mutasyonlar\u0131n kanserler aras\u0131nda olduk\u00e7a yayg\u0131n oldu\u011funu belirten biliminsanlar\u0131, \u00e7al\u0131\u015fmalar\u0131nda odakland\u0131klar\u0131 KRASG12C hakk\u0131nda baz\u0131 bilgiler de veriyor: KRASG12C mutasyonu k\u00fc\u00e7\u00fck h\u00fccreli olmayan akci\u011fer kanserlerinin yakla\u015f\u0131k y\u00fczde 13’\u00fcnde g\u00f6r\u00fclmektedir ve genellikle t\u00fct\u00fcn kullan\u0131m\u0131 ile ili\u015fkilidir. Ayr\u0131ca bu mutasyon kal\u0131n ba\u011f\u0131rsak kanserlerinin y\u00fczde \u00fc\u00e7\u00fcnde g\u00f6zlenmektedir. Mutasyonu hedefleyen ila\u00e7lar geli\u015ftirilse de t\u00fcm\u00f6r h\u00fccreleri bu ila\u00e7lara kar\u015f\u0131 diren\u00e7 kazanabilir. Diren\u00e7 mekanizmalar\u0131 ise bilinmiyordu, fakat yeni \u00e7al\u0131\u015fma bu konuda yeni veriler sundu.<\/p>\n

Ara\u015ft\u0131rmac\u0131lar, 38 hastadan KRASG12C mutasyonlar\u0131 ta\u015f\u0131yan kanser h\u00fccresi \u00f6rnekleri ald\u0131. Analizler, kanserlerden yedisinde direncin farkl\u0131 nedenleri oldu\u011funu g\u00f6sterdi ve 17 hastadaki direncin nedenlerini tan\u0131mlad\u0131.<\/p>\n

Diren\u00e7 mekanizmalar\u0131 \u00fc\u00e7 kategoride incelenebilir: KRAS genindeki yeni de\u011fi\u015fiklikler, KRASG12C d\u0131\u015f\u0131ndaki bir dizi yap\u0131daki anormallikler, akci\u011fer adenokarsinomlar\u0131n\u0131n karsinomlara d\u00f6n\u00fc\u015f\u00fcm\u00fc. \u0130lk iki kategorideki diren\u00e7 mekanizmalar\u0131na sahip hastalar neredeyse e\u015fitti ve bir\u00e7ok hastada her iki tip diren\u00e7 mekanizmas\u0131 da bulunmaktayd\u0131.<\/p>\n

\u00c7al\u0131\u015fman\u0131n devam\u0131ndaki analizler, hastalarda h\u00e2lihaz\u0131rda bulunan mutasyonlar\u0131n tan\u0131mlanmas\u0131n\u0131n yan\u0131 s\u0131ra dirence neden olabilecek olas\u0131 t\u00fcm mutasyonlar\u0131n atlas\u0131n\u0131n \u00e7\u0131kar\u0131lmas\u0131n\u0131 sa\u011flad\u0131. Bu atlas, diren\u00e7 mutasyonlar\u0131n\u0131 ta\u015f\u0131yan hastalar i\u00e7in tedavi \u00f6nerileri yap\u0131l\u0131rken rehber g\u00f6revi g\u00f6rebilecek kapsamdad\u0131r.<\/p>\n

Kaynak:<\/strong> https:\/\/medicalxpress.com\/news\/2021-06-uncovers-cancers-common-mutation-resistance.html<\/p>\n","protected":false},"excerpt":{"rendered":"

Yeni \u00e7al\u0131\u015fma, belirli bir proteini hedefleyen kanser ila\u00e7lar\u0131na kar\u015f\u0131 t\u00fcm\u00f6rlerin nas\u0131l diren\u00e7 geli\u015ftirdi\u011fini a\u00e7\u0131kl\u0131yor. Ara\u015ft\u0131rmac\u0131lar, \u00e7al\u0131\u015fmalar\u0131nda, KRASG12C proteinini hedefleyen ila\u00e7lara diren\u00e7li hale gelen t\u00fcm\u00f6rlerin genomik yap\u0131lar\u0131n\u0131 anlamaya odakland\u0131. Ara\u015ft\u0131rma, bu tipteki t\u00fcm\u00f6rlerin diren\u00e7 geli\u015fimi i\u00e7in ortak bir yoldan ziyade farkl\u0131 yolaklar\u0131 kulland\u0131\u011f\u0131n\u0131 g\u00f6stermektedir. New England Journal of Medicine‘da yay\u0131nlanan \u00e7al\u0131\u015fma, KRASG12C proteinini i\u015flevsiz hale getiren […]<\/p>\n","protected":false},"author":1390,"featured_media":48637,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[5101,7768,445,444,2660],"class_list":["post-50672","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-direnc","tag-genomik","tag-ilac","tag-kanser","tag-tumor"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t