{"id":51080,"date":"2021-07-30T10:42:31","date_gmt":"2021-07-30T07:42:31","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=51080"},"modified":"2021-07-30T10:42:31","modified_gmt":"2021-07-30T07:42:31","slug":"tuberkuloz-etmeninin-bagisikligi-baskilamak-icin-kullandigi-yeni-bir-yol-kesfedildi","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2021\/07\/30\/tuberkuloz-etmeninin-bagisikligi-baskilamak-icin-kullandigi-yeni-bir-yol-kesfedildi","title":{"rendered":"T\u00fcberk\u00fcloz etmeninin ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 bask\u0131lamak i\u00e7in kulland\u0131\u011f\u0131 yeni bir yol ke\u015ffedildi"},"content":{"rendered":"

T\u00fcberk\u00fcloz etmeni olan Mycobacterium tuberculosis<\/em> (Mtb) bakterisi bir ki\u015fiyi enfekte etti\u011finde v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k tepkisi, hastal\u0131\u011f\u0131n ilerleyi\u015fi i\u00e7in kritik \u00f6neme sahiptir. Bu ba\u011f\u0131\u015f\u0131kl\u0131k tepkisi ya v\u00fccudun bakteriyle sava\u015fmas\u0131na yard\u0131mc\u0131 olur ya da enfeksiyonu \u015fiddetlendirir.<\/p>\n

Ara\u015ft\u0131rmac\u0131lar yeni \u00e7al\u0131\u015fmalar\u0131yla birlikte, Mtb\u2019nin ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerinin savunmas\u0131nda d\u00fc\u015f\u00fc\u015fe neden olan bir yol ke\u015ffetti. Biliminsanlar\u0131 bakteride, enfekte olmu\u015f insan h\u00fccrelerinde enfeksiyonu \u015fiddetlendirebilecek ve ba\u011f\u0131\u015f\u0131kl\u0131k savunmas\u0131n\u0131 bask\u0131layan bir gen tan\u0131mlad\u0131lar.<\/p>\n

Yeni bulgu, D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fc’ne g\u00f6re y\u0131lda yakla\u015f\u0131k olarak 10 milyon hastal\u0131k vakas\u0131 ile 1-2 milyon \u00f6l\u00fcm\u00fcn sebebi olan t\u00fcberk\u00fcloz i\u00e7in gen temelli bir tedavi veya \u00f6nleyici tedavi i\u00e7in de\u011ferlendirilebilecek bir hedefe i\u015faret edebilir. Mevcut tedaviler sadece y\u00fczde 85 oran\u0131nda etkilidir ve ilaca diren\u00e7li t\u00fcberk\u00fcloz t\u00fcrleri d\u00fcnyan\u0131n bir\u00e7ok yerinde halk sa\u011fl\u0131\u011f\u0131 tehdidi olu\u015fturmaktad\u0131r.<\/p>\n

PLOS Pathogens<\/em> dergisinde yay\u0131nlanan \u00e7al\u0131\u015fmada ara\u015ft\u0131rmac\u0131lar, makrofajlar\u0131 ya Mtb (t\u00fcberk\u00fcloza neden olan bakteri) ya da \u00f6ld\u00fcr\u00fcc\u00fc olmayan bir bakteri ile enfekte etti. B\u00f6ylece h\u00fccrenin tepkisi izlenebildi. Ara\u015ft\u0131rmac\u0131lar, inflamazom ad\u0131 verilen bir protein kompleksinin, Mtb ile enfekte olan h\u00fccrelerde \u00f6nemli \u00f6l\u00e7\u00fcde az oldu\u011funu buldu. \u0130nflamazom, h\u00fccreyi patojenler i\u00e7in ara\u015ft\u0131r\u0131r ve bir ba\u011f\u0131\u015f\u0131kl\u0131k tepkisi ba\u015flatmas\u0131 i\u00e7in sinyal verir.<\/p>\n

Daha sonra ekip, belirli bir Mtb geninin iltihaplanmay\u0131 bask\u0131lamakla i\u015flevli olup olmad\u0131\u011f\u0131n\u0131 ara\u015ft\u0131rmaya ba\u015flad\u0131. Ara\u015ft\u0131rmac\u0131lar, \u00f6ld\u00fcr\u00fcc\u00fc olmayan bir mikobakteri t\u00fcr\u00fcne Mtb genleri yerle\u015ftirdi ve bu mutantlar\u0131 yeni makrofajlar\u0131 enfekte etmek i\u00e7in kulland\u0131. PknF adl\u0131 Mtb genini ta\u015f\u0131yan bakterilerle enfeksiyonlar\u0131n, konak\u00e7\u0131 h\u00fccrelerde ba\u011f\u0131\u015f\u0131kl\u0131k tepkisini s\u0131n\u0131rlad\u0131\u011f\u0131n\u0131 ke\u015ffettiler.<\/p>\n

PknF’nin konak h\u00fccrelerin iltihaplanmas\u0131n\u0131 nas\u0131l bask\u0131lad\u0131\u011f\u0131 ara\u015ft\u0131rmac\u0131lar\u0131n yan\u0131tlamak istedi\u011fi sorulardan sadece biri. Ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131n bask\u0131lanmas\u0131n\u0131n Mtb’nin daha \u00f6ld\u00fcr\u00fcc\u00fc olmas\u0131na yol a\u00e7t\u0131\u011f\u0131 ortaya \u00e7\u0131karsa, PknF geni, hastal\u0131\u011f\u0131 tedavi etmek i\u00e7in iyi bir hedef haline gelebilir.<\/p>\n

Kaynak:<\/strong> https:\/\/medicalxpress.com\/news\/2021-07-scientists-tuberculosis-suppresses-immunity.html<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00fcberk\u00fcloz etmeni olan Mycobacterium tuberculosis (Mtb) bakterisi bir ki\u015fiyi enfekte etti\u011finde v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k tepkisi, hastal\u0131\u011f\u0131n ilerleyi\u015fi i\u00e7in kritik \u00f6neme sahiptir. Bu ba\u011f\u0131\u015f\u0131kl\u0131k tepkisi ya v\u00fccudun bakteriyle sava\u015fmas\u0131na yard\u0131mc\u0131 olur ya da enfeksiyonu \u015fiddetlendirir. Ara\u015ft\u0131rmac\u0131lar yeni \u00e7al\u0131\u015fmalar\u0131yla birlikte, Mtb\u2019nin ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerinin savunmas\u0131nda d\u00fc\u015f\u00fc\u015fe neden olan bir yol ke\u015ffetti. Biliminsanlar\u0131 bakteride, enfekte olmu\u015f insan h\u00fccrelerinde enfeksiyonu \u015fiddetlendirebilecek […]<\/p>\n","protected":false},"author":1390,"featured_media":51081,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[1194,7837,431,1631,6558],"class_list":["post-51080","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","tag-bagisiklik","tag-baskilama","tag-gen","tag-hastalik","tag-tuberkuloz"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/51080","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1390"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=51080"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/51080\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media\/51081"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=51080"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=51080"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=51080"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}